4 genomes BUD2256 4 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi - - HVO_0692 Hbo0845 - - hla0123 - HQ1262A

Pairwise sequence scores
Consensus score	2211	hla0123	HQ1262A	HVO_0692	Hbo0845
1746	hla0123	2250	1447	1504	1529
1706	HQ1262A	1447	2265	1422	1573
1857	HVO_0692	1504	1422	2181	1708
1932	Hbo0845	1529	1573	1708	2201

309 symbols
consensus       --MMTIGFIGGSGIYEALPLQNTREVEVETPFGEPSAPPTVGEFGDTGREVVFLPRHGPD
#oth            11121..........1..1.211112121..1.1.122211..1.1..1..2.1....22
hla0123         :::S::::::::::::::::NDV::::YD::Y::::DAI:I:::::::K::A::::::SN
HQ1262A         MY:T::::::::::::::G::::HTI:I:::::::A::L::::V:E:::::I::::::TS
HVO_0692        ::-:K:::::::::::::::E::::EP:::::::::TT:V::::::::::::::::::::
Hbo0845         ::-::::::::::::D:::::D::T::::::Y:N:::::::::::::::::::V::::::

consensus       HQRSPTTLPYRANIFALKQAGVTHVLASNAVGSLREELPPQTLVIPDQIYDRTKHRDLTF
#oth            .23...22..1..11...21....12........11112.21..1....1......211.
hla0123         :GV:::D::::::MY:::K:::::IF::::::::KA::E:G:::V:::::::::::::S:
HQ1262A         :EY::::V:::::::::::::::::I:::::::::::IS:RM::::::::::::::TS::
HVO_0692        ::H::::::::::::::::L::::::::::::::K:D:::::::V:::::::::::P:::
Hbo0845         ::::::AI::C:::::::EL:::::::::::::::::::::::::::::F:::::::S::

consensus       FDDGIVVHQPFADPYCTELVSILTEAAEE---------TATDANVVKGGTYVCIEGPQYS
#oth            12111.1..1..3..22..2211111.111111111121.2.231121.........11.
hla0123         YG::V::::::::::SP:::DH::::::SAVGGDGEGD::D:T:::::::::::::::::
HQ1262A         :S::::A::Q::T::::::R::V:DV:M:::::::::N::A:IDI::D::::::::::F:
HVO_0692        ::E:::::::::M::DE::::::A::::::::::::::-::::Q:QE::::::::::S::
Hbo0845         ::ED::::::::E::::::NE:::::::::::::::::-::::K::R:::::::::::::

consensus       TRAESEFYRSQGWDIIGMTTIPEAKLAREAEMAYATIAGVTDYDVWKEDSEVTLEEVLKN
#oth            .1....1.12....21...1...........2..1.11.........2.11...2...2.
hla0123         ::::::::K:::::LV:::A:::::::::::I:::::::::::::::A::::::A:::E:
HQ1262A         :::::::::::::::::::::::::::::::L::V::::::::::::::TQ:::::::S:
HVO_0692        :K::::H::A::::V::::::::::::::::::::::T:::::::::D::::::D:::::
Hbo0845         :::::::::E::::::::::::::::::::::::::VT::::::::::::::::::::::

consensus       AEANQKAIKETVEAAIRTIPDGHECDCHSALEGTINTPDEAIPEDTREDLEPLIGEYVD-
#oth            .13.12...2211111321.2212122.11.2..1..122...221122121.112.231
hla0123         ::Q::::::AA::E:V::L:::L:::A:TS::::V:::T:::::::::RV:::L:D:L-:
HQ1262A         ::R::::::SVLT:V:N:::AE:T:A::TS:A:::::EKT:::DS:::::DL:::::ISE
HVO_0692        :A::EE::::::::::HK::::::T:S::::::::::::::::AE:KAK:A:::D:::::
Hbo0845         ::K:ET::::::::::EA::ED:D:S:::::D:::::::D:::::VKS:::::::R::E:

consensus       ---------
#oth            111111111
hla0123         :::::::::
HQ1262A         DTTGGEETG
HVO_0692        :::::::::
Hbo0845         :::::::::