[K] (SPT15) COG2101 TATA-box binding protein (TBP), component of TFIID and TFIIIB 1 genomes BUD4421 6 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG5052 VNG5163 VNG5245 VNG6050 VNG6438 VNG6476 - - - - - - - -

Pairwise sequence scores
Consensus score	1370	VNG5163	VNG5052	VNG5245	VNG6050	VNG6476	VNG6438
1085	VNG5163	1398	1085	1085	1085	1085	1062
1370	VNG5052	1085	1370	1370	1370	1370	1201
1370	VNG5245	1085	1370	1370	1370	1370	1201
1370	VNG6050	1085	1370	1370	1370	1370	1201
1370	VNG6476	1085	1370	1370	1370	1370	1201
1201	VNG6438	1062	1201	1201	1201	1201	1358

186 symbols
consensus       MSTLADTIHIENVVASSDLGQELALDQLSTDLPGAEYNPEDFPGVVYRLQEPKSATLIFR
#oth            ..1.1...1.......1..1.....1..1...1......1.....1...11........1
VNG5163         ::::T:::Q:::::::T::S:::::E::A::::::::::G:::::I:::DD::::::::D
VNG5052         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
VNG5245         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
VNG6050         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
VNG6476         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
VNG6438         ::S:::::::::::::::::::::::::A:::D:::::::::::::::::::::::::::

consensus       SGKVVCTGAKSVDDVHEALGIVFGDIRELGIDVTSNPPIEVQNIVSSASLEQSLNLNAIA
#oth            ...1.....1...1..1.12..12.1.1....1212..12.....1.1..1.1.......
VNG5163         :::A:::::Q::::::D:IS::VE:L:D::::IPPS::VH:::::C:G::D:D:::::::
VNG5052         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
VNG5245         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
VNG6050         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
VNG6476         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
VNG6438         :::::::::::::A::D::E:::D:L:::::::D:T::VK::::::::::::::::::::

consensus       IGLGLEQIEYEPEQFPGLVYRLDDPDVVVLLFGSGKLVITGGQNPDEAEQALAHVQDRLT
#oth            ......11..............1..................121111.21..11121...
VNG5163         ::::::DV::::::::::::::N:::::::::::::::::::S:::D:HH::EIIHE:::
VNG5052         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
VNG5245         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
VNG6050         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
VNG6476         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
VNG6438         :::::::::::::::::::::::::::::::::::::::::AAESAD:QH:::::N::::

consensus       ELGLLD
#oth            1....1
VNG5163         D::::E
VNG5052         ::::::
VNG5245         ::::::
VNG6050         ::::::
VNG6476         ::::::
VNG6438         :::::E