[V] (-) COG1002 Type II restriction enzyme, methylase subunits 1 genomes BUD4442 2 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG5138 VNG6135 - - - - - - - -

Pairwise sequence scores
Consensus score	5399	VNG5138	VNG6135
5399	VNG5138	5399	5051
5051	VNG6135	5051	5051

706 symbols
consensus       MQTALTYRTNRDLFSNHYLDEHLPETEEWDEVSDEELQEAYDDIMALWEREKDTAPKRNE
#oth            11111111111111111111111111111111111111111111................
VNG5138         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
VNG6135         --------------------------------------------::::::::::::::::

consensus       SQLEEKFIRPMFRKLGIPFEVEESTSRTQRRPDYGFFDTEDAARDAFERREEGGDFYENA
#oth            ............................................................
VNG5138         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
VNG6135         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       VAVADAKRWGRPLDTRGSGEHERDFENPSYQIHVYLQETPARWAVLTDGKKWRLYYGPTS
#oth            ............................................................
VNG5138         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
VNG6135         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       HRLDSYYEVDLPTILESGDLEDFKYFYLFFRHEAFLDDGSGDCFLDDVYDESNVFAQELG
#oth            ............................................................
VNG5138         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
VNG6135         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       EDLQDNIYEAIKILSEGYLQYPENDLDEGDLDLIHDSSLIYLYRLIFVLYAEAEGRELLD
#oth            ............................................................
VNG5138         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
VNG6135         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       TSNEIYEQSYSLNSLKQEIAEELDSGDPKYRDWQDNLQSRLDELFTLINKGSKSRGIPEE
#oth            ............................................................
VNG5138         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
VNG6135         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       DLYIPAYNGGLFRTDPDEDDSAEAKFLANHDVGDAYLAKVVELLTRSKNNDGGGKIFVDY
#oth            ............................................................
VNG5138         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
VNG6135         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       SSLDVRHLGSIYEGLLEYQLNVADEPLALDDGEYVSADEGDDVVVQEGEVYLTTDSGERK
#oth            ............................................................
VNG5138         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
VNG6135         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       ATGSYYTPEYVVEYIVENTLEPLVDDIRADLAGRSARGEDRGFAEEFAERIFDLKILDPA
#oth            ............................................................
VNG5138         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
VNG6135         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       MGSGHFLTSAIDYLAREIIDAQERQAAQQGIETVNQDHDINWARRQVAQRCIYGVDLNPL
#oth            ............................................................
VNG5138         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
VNG6135         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       AVELAKVSLWLRTLAAEQPLAFLDHHLKTGNSLVGSNVEEIDALERNGAAEAEGPNSTLI
#oth            ............................................................
VNG5138         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
VNG6135         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       DFGMTFEGTMENLMAIHADLIAIENEELEDVKAMEKKYQYITKPLS
#oth            ..............................................
VNG5138         ::::::::::::::::::::::::::::::::::::::::::::::
VNG6135         ::::::::::::::::::::::::::::::::::::::::::::::