1 genomes BUD4555 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi - - - Hbo0070 Hbo0488 Hbo1206 Hbo1462 Hbo1695 Hbo2017 Hbo2039 Hbo3704 Hbo4047 - - - - -

Pairwise sequence scores
Consensus score	2753	Hbo4047	Hbo0488	Hbo0070	Hbo2017	Hbo1695	Hbo2039	Hbo1206	Hbo3704	Hbo1462
1774	Hbo4047	3680	1456	1458	1556	1412	1477	1494	1612	1495
1835	Hbo0488	1456	3370	1462	1359	1534	1547	1529	1645	1678
1676	Hbo0070	1458	1462	2798	1430	1452	1486	1470	1510	1509
1875	Hbo2017	1556	1359	1430	3285	1911	1513	1422	1436	1353
1945	Hbo1695	1412	1534	1452	1911	2865	1596	1507	1523	1553
1908	Hbo2039	1477	1547	1486	1513	1596	4347	1634	1761	1670
1847	Hbo1206	1494	1529	1470	1422	1507	1634	3522	1676	1667
1941	Hbo3704	1612	1645	1510	1436	1523	1761	1676	3318	1674
1870	Hbo1462	1495	1678	1509	1353	1553	1670	1667	1674	2807

661 symbols
consensus       ------------------------------------------------------------
#oth            111111111122233313333333323323332323233323222222121211321132
Hbo4047         ::::::::::MGFRTARENTTETERSSIWSRDESDSSRHQRHRRGPRFTAQECEDLFGID
Hbo0488         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo0070         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo2017         :::::::::::::MGFRSANEVQKKTQWSPSSERDRVDSSRRQRSGRLTAQGCEQRFGMD
Hbo1695         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo2039         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo1206         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo3704         MAIKFAVRMRFRSANERTTPSKESSSVPSIQELTGGSNRNQSRGGGSLTPQECESRFGVE
Hbo1462         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       --MDGLDTKIQRLAKKHGADQVRQWADEGMTVDTMGKPRDMRAFRQRQKERPAEVPKDIE
#oth            2111..1111...112...1..11..........1..........1..11........1.
Hbo4047         MY::::EV:V::::DS:::G:::::::::::::::::::::::::E::::::::::::::
Hbo0488         :::::::::::::::::::::::E::::::::::::::::::::::::Q:::::::::::
Hbo0070         ::::::E::::::::::::::::::::::::::::::::::::::E:::Q::::::::V:
Hbo2017         MYRN::EVIV:::V:Q:::G::Q::::::::::::::::::::::E:::Q::::::::::
Hbo1695         :::::::::::::::::::G:::E::::::::::I:::::::::::::::::::::::::
Hbo2039         :::::::::::::::::::G:::E:::::::::::::::::::::E:::Q::::::::::
Hbo1206         :::::::::::::::::::::::E::::::::::::::::::::::::::::::::::::
Hbo3704         IY::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo1462         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       RRNAKSVQRSRGAHHEASKAGDANVPDSVRDVISSPGQQLDTSIQRAMEDRMGDNLGDVR
#oth            ...................1.111.......1.....11.121..11..1...12.2...
Hbo4047         :::::::::::::::::::::::::::::::I:::::::::AG::Q:::E::::::::::
Hbo0488         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::S:::
Hbo0070         :::::::::::::::::::::::::::::::::::::K:::S::::::::::::T:::::
Hbo2017         :::::::::::::::::::S:N:Q:::::::::::::::::S:::Q:::E:::ES:D:::
Hbo1695         ::::::::::::::::::::::TQ::::::::::::::S:NA::::V:::::::::::::
Hbo2039         ::::::::::::::::::::::T:::::::::::::::::::::::::::::::::::::
Hbo1206         ::::::::::::::::::::::T:::::::::::::::::::::::::::::::::::::
Hbo3704         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo1462         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       IHTGPSAAKACEDINARAFTVGNHIAFNHGEYDPSSAEGQHILAHELAHVRQQTGGAVSM
#oth            1..112..1...............1.......1...1....2..............1...
Hbo4047         :::::Q:::::::::::::::::::::::::::::::::::V::::::::::::::::::
Hbo0488         :::D::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo0070         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo2017         ::::SR::N:::::::::::::::V:::::::::::T::::L::::::::::::::::::
Hbo1695         ::::::::::::::::::::::::V:::::::H:::::::::::::::::::::::T:::
Hbo2039         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo1206         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo3704         V:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo1462         V:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       LPQEGELEIDPDPRLEREAEETAQRVMQGGKIGVHRMEHSDVHVQRMPA-----DRSELG
#oth            ...2.31.....1..........1...2...1.12..2212..1..62633222665654
Hbo4047         :::T:A::::::E::::::::::::::::::::::::HN::::I:::::DM:::VPEA:E
Hbo0488         :::::S::::::::::::::::::::::::::::::::::::::::S:K::::::V::YI
Hbo0070         :::T::I:::::E::::::::::N:::R:::L:IF::GKAS:::::I:D:::::KQ:S:E
Hbo2017         :::::K::::::E::::::::::::::S:::L:IY::HKA:::I::WRDQ::::P:DNI:
Hbo1695         ::::::::::::::::::::::::::::::::::Y:::::E:::::HHEDQKRRPNG:F:
Hbo2039         ::::::::::::::::::::::::::::::::::::::::::::::V:-:::::QSAR::
Hbo1206         :::A::::::::::::::::::::::::::::::::::::::::::::RWNNLP::DTVA
Hbo3704         :::::S::::::::::::::::::::::::::::::::::::::::T:::::::EV:VEN
Hbo1462         ::::::::::::::::::::::::::::::::::::::::::::::::G:::::AETV::

consensus       RFAA---KDRE------QREQKEEGQELREDYDPGKLEEV--------------------
#oth            654511167773333235753546663654746455635311111111111111111112
Hbo4047         M:K::::ENQGGAVGSF:QR:NQ:RI:FI:EQVEQ::KNL:::::::::::::::::::D
Hbo0488         PSMG:::DTEQ::::::AIIEE:AT:GVLL:I::E:::QL::::::::::::::::::::
Hbo0070         ::TD:::S::DHPPHPIKNQSATF:TASSN::RTNFF:AY::::::::::::::::::::
Hbo2017         :::E:::::T::::::::YK::KYSIDH:PP:A::QV:::::::::::::::::::::::
Hbo1695         PLKEEIA:K:T::::::K::E:PY:HDQ:PR:E::QR:::::::::::::::::::::::
Hbo2039         LALS::::FDI::::::DE::E:KIRA:L:S:SE:-S:SLRPELLAALLNANGTDTPRGF
Hbo1206         SPLV:::ALK:::::::MGLSD:LLA::EQTV:DD:YD:F::::::::::::::::::::
Hbo3704         NY:G:::----::::::I::L:::VS::K:KVNS:WS:K:::::::::::::::::::::
Hbo1462         GAT::::LVASQMMIPKML:EG:QL::I::NW:DIDGH::::::::::::::::::::::

consensus       --NRALADGDSAALAAANAEEENDVAELRAAGE---------------------------
#oth            245666555558468566566685256655433111111111111111111111111111
Hbo4047         TLQNS:T:Q:EQI:D:RAEG::EL::D:Q::KT:::::::::::::::::::::::::::
Hbo0488         ::QS:V::LEEL:TEINELSAATG:TVEP:::::::::::::::::::::::::::::::
Hbo0070         ::--PWLE:EVVIHH:VEQQVQQLWP::VTDS::::::::::::::::::::::::::::
Hbo2017         :W:::RSE:IDDKVRDP:T::VLTWDKD:GR:::::::::::::::::::::::::::::
Hbo1695         :W:::KG---------P:GVVFCA:D:VPLDRD:::::::::::::::::::::::::::
Hbo2039         DFAED::ID::GS:SSDQQ:QL::LLGY:TE:NASAVDQVIATGDSSALEIAERRGTDLF
Hbo1206         :FEDLWRI:::PKDLG:SEGDVGE:LSSHPEKN:::::::::::::::::::::::::::
Hbo3704         :AGGMA:V:S:::V:GTR:AL:S:L:QTIEG:::::::::::::::::::::::::::::
Hbo1462         ::----:YEGFK:QM::Y:NIIPG:KGV:::KN:::::::::::::::::::::::::::

consensus       -------------------------------MGHKQQREYEKLEQDALQGEVTREEFLKE
#oth            113333322233223322235332332323464676654664566557664567646555
Hbo4047         ::::::::::::::::::::::::::::::AIQERISEL:ATI:DK:D:IAL:D:QRE:L
Hbo0488         ::TTLREETPTPLRDGLAVTVSHDHDLSEMGLSQD::KLV::HK:LVSEF:TLSNDI:S:
Hbo0070         ::::::::::::::::::::::::::::::MHSLENL:GIP:ELNAEIHLSQI:K:WDDF
Hbo2017         ::::::::::::::::::::QWH::::::::::::K::::RY:LEYYQ::IISE:::V::
Hbo1695         ::::::::::::::::::::EWC::::::::::::PR:::WY:VEYY:R:II::::::A:
Hbo2039         SAVMGTTVEDFSEYHAATLGKWRRNLLTEIAE::GSE:IL:Y:ARLEETMD:AQRDATTV
Hbo1206         ::LVESFVEDSDERGELAVVPGHDSMVKGVQVNSSRNP:FD::IV:KKS:::VKVVEE:V
Hbo3704         :::::::::::::::::::::::::::::::--TLSKMIPHAG:IM:HHP:::AAVG:TA
Hbo1462         :::::::::::::::::::::::::::::::--NA::QFK:SNF::R:AEANFPDSWKGQ

consensus       YANDDHYGA--EAARD-ASRVFDGIG-------------------------------DGF
#oth            367535346115565455655536534443344344434244333323221111111546
Hbo4047         :GDT:FD:G:::F:MEFGWTL:KAGMSLVPGFGIAIAGLEISE::::::::::::::TL:
Hbo0488         LQQGELPEE::STF::FLTD:GIST:VAAVVYKAIESQTDHATLASML:::::::::QSE
Hbo0070         :LKHKSPDK::QQLL:K:TEID:KY:::::::::::::::::::::::::::::::::M:
Hbo2017         :Q:P:::Q:::::P:ENMG:RHE:V::::::::::::::::::::::::::::::::RYW
Hbo1695         :R:P:::QP:::SH:ASS:GEHEQE::::::::::::::::::::::::::::::::EYW
Hbo2039         VDG::SI:S::LSNN::PNS::::VAFETERLAAYVRQSEYVEMEPDREDRIDILAVE:N
Hbo1206         GST::D:AS::K:TKQ::K:ALKD:DYGIPRGETGKPKIENIDRLNDCIN::::::::LS
Hbo3704         V:SGGL:::::QQ:V::G:GI::R:::::::::::::::::::::::::::::::::::V
Hbo1462         L:EM:PPETWLDE::RV:QE:S::T::::::::::::::::::::::::::::::::S:D

consensus       KEKWGPQEAEL-------------------------------------------------
#oth            457445754655433233233233234444432553345444444333544222222222
Hbo4047         R:TMKQTDGS:AERLTQTMDILVKSGKTGTGDSQGVGSSRGMHNGWTNYWRK::::::::
Hbo0488         LDMV:::G:G:FENITVAFGALLTGIALSYGKDKLTSHDETGDTRFDDK:::::::::::
Hbo0070         EPSVRD-----:::::::::::::::::::::::::::::::::::::::::::::::::
Hbo2017         :Q:::DI:G:KHG:::::::::::::::::::::::::::::::::::::::::::::::
Hbo1695         A:::::L:---:::::::::::::::::::::::::::::::::::::::::::::::::
Hbo2039         :AI:AE:KSPKKGYVDKDFISGEIGKTIDKFESDSVSKKIEDVSNEFNVDHHERIVELNF
Hbo1206         E:DF:NA::CT::::::::::::::IVPKGMDDSHEESTHVETYKWTSEELKLMYNIAHD
Hbo3704         :SAF:HVKSKFSR::::::::::::::::KDESEREEEEREEDSGWFSGLN:::::::::
Hbo1462         RPERV:SAD:VSK:::::::::::::::::::::::::::::::::::::::::::::::

consensus       ------------------------------------------------------------
#oth            221211111111111111111111111111111111111111111111111111111111
Hbo4047         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo0488         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo0070         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo2017         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo1695         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo2039         KSPIDEKGELRGKPLEDAKRYIESYIMKKIQFGSVPIDAVRIVVGNKVITGKINKNEVQW
Hbo1206         VRPW::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo3704         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo1462         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       -
#oth            1
Hbo4047         :
Hbo0488         :
Hbo0070         :
Hbo2017         :
Hbo1695         :
Hbo2039         Q
Hbo1206         :
Hbo3704         :
Hbo1462         :