[F] (Pnp) COG0005 Purine nucleoside phosphorylase 9 genomes BUD0637 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG0335 rrnAC1757 HVO_0694 Hbo0842 Hmu3012 Hut0396 hla0117 NP1204A HQ1260A

Pairwise sequence scores
Consensus score	1802	Hut0396	hla0117	HQ1260A	VNG0335	NP1204A	HVO_0694	Hbo0842	Hmu3012	rrnAC1757
1520	Hut0396	1806	1256	1398	1333	1356	1417	1395	1298	1302
1458	hla0117	1256	1809	1265	1293	1395	1407	1425	1230	1172
1488	HQ1260A	1398	1265	1985	1348	1382	1454	1465	1255	1199
1458	VNG0335	1333	1293	1348	1804	1295	1407	1379	1230	1216
1557	NP1204A	1356	1395	1382	1295	1799	1463	1470	1274	1275
1610	HVO_0694	1417	1407	1454	1407	1463	1860	1681	1268	1301
1615	Hbo0842	1395	1425	1465	1379	1470	1681	1857	1271	1304
1392	Hmu3012	1298	1230	1255	1230	1274	1268	1271	1806	1389
1371	rrnAC1757	1302	1172	1199	1216	1275	1301	1304	1389	1791

254 symbols
consensus       MSDLPDEFNCTITNWEYIYGLCRDVSDDVKAADFEPDVVVALARGGWFAGRCLCDFLGLD
#oth            .21..12.3..2.1.....21..2.11411322.1...1.1.......1..11......1
Hut0396         :A:::E::P::::::::::::::::::::::D::::::::S::::::::::T::::::::
hla0117         ::::::D:D::L:::::::::::N::NA::R:::::::::::::::::::::I::::::N
HQ1260A         ::::::Q::::::::::::D::::::NQIR:DS:D:::::::::::::::::::::::::
VNG0335         ::::::D::::::::::::::::::::Q:::::::::::::::::::::::::::::::N
NP1204A         :::::::::::V:::::::S:::::A:H::::E:::::::::::::::::::::::::::
HVO_0694        :G:::::::::::::::::::::::::E::TSE:::::I:::::::::::::I:::::::
Hbo0842         :G::::::::::::::::::R::::::Q::G:E:D:::::::::::::::::I:::::::
Hmu3012         :::::E::S::::::::::D:::R:AN:::::::::::::::::::::G:::::::::::
rrnAC1757       :GE:::::S::::D:::::::::::A::::::E:::::::::::::::G:::::::::::

consensus       DLTSLKMEHYVGTAQKSNEPEVRYPMPEGSVEGKDVLIIDDIADTGGSIERAYEYVTERD
#oth            ..1...2.....112225.1211..11211.12.1..11.......2.142.311.5112
Hut0396         ::::::I:::::::A::Q:::::::::::::A::::::V:::::::Q:L:H:::::S:::
hla0117         ::::::::::::A:E::D::QI:::::::::::::::::::::::::::R::E:::DD::
HQ1260A         :::::::::::::::TT::::I:::::Q:::AE::::::::::::::::::::::::D::
VNG0335         ::::::::::::::E::A::::::::::::::D:::::::::::::::::H:H:::QD::
NP1204A         :::::::::::::G:::D::Q:::::::::::::N::V:::::::::::S::::::::::
HVO_0694        :::::::::::::::::::::::::::::::::::::::::::::::::K::H:::N::N
Hbo0842         :::::::::::::::::G::::::::::::::::::::::::::::::::::::::::::
Hmu3012         ::::::V::::::::SGQ:AKIK::::DD::AD::::VV:::::::K::QT:AD::R:AG
rrnAC1757       ::A:::V:::::::A:GE:AQ:K::LAD:A:::::::VV:::::::Q:::T:A:C:RD:N

consensus       ANEVRTATLQLLQTSEFEPDFVGERLEEWTWVVYPWNFIEDMIDLISGVMAKADQDTFDE
#oth            133.........2..211.111..1.22.2.1......2...2113412.223.262235
Hut0396         P:A:::::::::::::::::::::::A::V::::::::::::T::::S::::::AE::S:
hla0117         :G::::::::::G::::Q:::::::::Q::::::::::L::::::TE:A:ER:::TV::R
HQ1260A         P:I::::::::::::A:::::I:::::T:A::::::::::::T::LT:::R:T:AE::TI
VNG0335         ::A::::::::::::A::::Y:::::D::A:I::::::::::::I:A::::TD:DGPYTT
NP1204A         :A::::::::::D::::::E:::::::T:::::::::::::::E::G:::E:::A:::SR
HVO_0694        :G::::::::::::::::::Y::::::::A:::::::::::::::T::::::::D:::EL
Hbo0842         :G:::::::::::::::::::::::::::::::::::::::::::TT:::E::::A:::V
Hmu3012         PAS:::::::::D:::H:::::::::::::::::::::V::::E:L::L:::S::RVH::
rrnAC1757       PSS::::::::::::DH::E::::S:D:::::::::::V:::VE:VA:::::S::Q:HT:

consensus       EDIRHLLAEYHGVDRIEMEIAQPDRLDEVLSEMERRGVVEA-------------AGDD--
#oth            312.421431.4231121.1..12.16..33..2..133361111111111111213211
Hut0396         ::V:S::RS::E::P::::::::::MA:::T:::::::I:Y:::::::::::::::E:::
hla0117         ::V::Y:D:F::IG:::::V::AG::::::D::V::D:ADR:::::::::::::::EN::
HQ1260A         P:L:EG:K:::S:E:::::::::::ME:::D::Q:::Y:::VTTNEASGDTPVET:::VS
VNG0335         AG::D:::D::D::::Q:::::::::T::R:::V::D:LA::::::::::::::TDA:::
NP1204A         D::::Y:SA:::LE::::::::::::::::A::::::AARK:::::::::::::V:::::
HVO_0694        :::::Y:::F:D:::::::::::::MP::M:::::::Y::S:::::::::::::T::G::
Hbo0842         :::::Y:::F:N:::::::::::N:MS::M:::::::F::T:::::::::::::T::G::
Hmu3012         D:L:::FR:::::E::Q:::::::::::::T:::::D:I:W::::::::::::::DGG::
rrnAC1757       D:::R::R:::::S:TNL:::::N::G::TT:::::::::S::::::::::::::::G::

consensus       --AWRLVE------
#oth            114.3233422112
Hut0396         ::::::AAED::::
hla0117         ::::T:A:::::::
HQ1260A         QPT::I::TDEVGV
VNG0335         ::R:A::-::::::
NP1204A         ::::QPA-::::::
HVO_0694        ::::::L:NDGVGA
Hbo0842         ::E:::::NEGVGA
Hmu3012         ::-::::D::::::
rrnAC1757       ::-:Q:TDD:::::