[I] (UppS) COG0020 Undecaprenyl pyrophosphate synthase 9 genomes BUD0526 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG1779 rrnAC1716 HVO_2315 Hbo2003 Hmu2323 Hut0485 hla1191 NP4550A HQ3332A

Pairwise sequence scores
Consensus score	2340	hla1191	HQ3332A	HVO_2315	Hbo2003	NP4550A	VNG1779	Hut0485	rrnAC1716	Hmu2323
1793	hla1191	2597	1630	1568	1514	1420	1538	1471	1440	1472
1723	HQ3332A	1630	2404	1658	1606	1382	1469	1511	1362	1458
1781	HVO_2315	1568	1658	2378	1689	1427	1456	1558	1416	1455
1760	Hbo2003	1514	1606	1689	2255	1414	1424	1519	1403	1396
1666	NP4550A	1420	1382	1427	1414	2316	1513	1522	1380	1484
1755	VNG1779	1538	1469	1456	1424	1513	2310	1513	1441	1557
1823	Hut0485	1471	1511	1558	1519	1522	1513	2380	1585	1642
1760	rrnAC1716	1440	1362	1416	1403	1380	1441	1585	2362	1643
1765	Hmu2323	1472	1458	1455	1396	1484	1557	1642	1643	2321

344 symbols
consensus       ----MLSRGRRLAQRAYERLLQREIDGGPTHVAVIQDGNRRYAREQGDDAPDGHREGAQT
#oth            11221473545666431314.6112433.3.1.1.1.......134.54342.132..4.
hla1191         ::::::N:L:V:TE:::R:H:H:::EDV:::::I:::::::::::R::N::::::A::A:
HQ3332A         ::MS:FR:V:GVI::::V:A:::Q:TE::::::I:::::::::::::N::HE::::::::
HVO_2315        :::::FGWV::GFR:::::V:D::::D::::::I::::::::::KN::::::::KA::::
Hbo2003         ::::---------------M:R::LG:::A:::I::::::::::RR::E:::::K:::K:
NP4550A         ::::-MAP:AGYLS:L:::::E::VSAA:S:::::::::::::ET::EA:TA:::A::E:
VNG1779         :::::RT:LWDA:SAV:::::T:::::A:A:::::::::::::::H:::PT::YQS::R:
Hut0485         :::::R:WI:KQ:TSV:::::K:::::::::I::::::::::::KE:QETSA::::::E:
rrnAC1716       MYTT:::::K::GYA:::::::W:LS:T:D:::::M:::::::EK::TKKQE::K:::::
Hmu2323         ::::::Q:A:D:::T::::::E::LSDA:S:::::::::::::::::A:TTA:YT:::E:

consensus       TERVLEWCDELGVEELTLYAFSTENFDRPPEEREPLFDLIEDKLREFADADRVHEAGVRI
#oth            1.31.4..311113.1...1......2.15312331...215..13...3111.243.21
hla1191         :::::D::AD:::A::::::::::::E::D::L::::::L:T:::D:::::::::Q:::V
HQ3332A         ::::::::E:::I:::::::::::::T::DA:LQ:::::::S::Y:::::E:T::NS:::
HVO_2315        ::D::T::E:::I::::::T:::::::::EH::G::::::::::Y::::SE:::DRE:AV
Hbo2003         A:Q::H::E:F::::::::T:::::::::Q::L::::::::E::Y:::::E:::::::::
NP4550A         ::::::::AD::::::::::::::::E:::D:::A:::::AE:::::::HEE::DRE:::
VNG1779         ::::::::SD::::::::::::::::E:::DQQQH::::L:S::::::::::::ADR:::
Hut0485         ::AL::::::::I::::::::::::::::ADQ:AV:::::::::YD:::S::::::::::
rrnAC1716       ::AL:N::::::IR:V:::T::::::::D:::::HI:::V:Q:::T::::::::::::C:
Hmu2323         ::AL:H:::::A:D:V:::T:::::::::K:QQ:H::::::R:::A:::T::::DNE:::

consensus       RAIGETDRLPERVRDAIDYAESRTAGYDGFTLNIALAYGGRAELLGAARDVARAVDAGDL
#oth            21..2232..3..12.23...31.241.415..1.......3...31223213213412.
hla1191         ::::DV::::::::::V::::R:::DN:R::::V:::::::T:::D::TAI::D::::::
HQ3332A         G:::DI::::Q::QS:VE::::Q::A::D:R::::::::::S:::R:::S::HD::::E:
HVO_2315        :::::VHL::D:::::VE:::::::D:::::::::::::::::::::::::C:::ER:::
Hbo2003         CT::::::::P:::E::E::::::R:::::C::::::::::::::::V:::::D:TS:T:
NP4550A         ::::Q:H:::D:::E:AA:::R::E:::ALR::::::::::::::DV:::I:AEAA::::
VNG1779         ::::D:G:::Q::::::T:::::::::::::::V:::::::D:::T:::G::D::A::::
Hut0485         ::::::H:::::::E::::::AQ:R:::Q:H::::::::::::::::VK:L:AD::R:::
rrnAC1716       ::::::EM:::::::::::::G:::Q::QLN:::::::::::::::::::::A::ENET:
Hmu2323         ::::::E::::::::::::::::::C::RLQ::V:::::::::::::T::I:::::D:E:

consensus       DPADVDVETIESRLYEGPTRDVDLIIRTGGDERTSNFLPWHANGNEAAVYFCAPYWPEFS
#oth            1.4412132115..4541111....1.1..1...........1.1...21..1......1
hla1191         ::T::::::V:E:::DR:V::::::V::::::::::::::::::::::::::::::::::
HQ3332A         ::ST::A::V:C::SRHT:::::::V::::::::::::::::::::::::::::::::::
HVO_2315        S:DE:::SAVDR::SRK:V::::::::P::::::::::::::::::::::::::::::::
Hbo2003         S:D::T::E:D:::CQH:::::::::::::A:::::::::::::::::::::::::::::
NP4550A         ::EA:T:DE:::::TA:::QA:::::::::::::::::::::::::::::::T:::::::
VNG1779         ::::I:AQA:::::HTS:V:::::::::::::::::::::::::S::::F::T:::::::
Hut0485         :::TI::::V:N::::::::::::::::::::::::::::::::::::A::::::::::R
rrnAC1716       ::T::SA::::E:::::::::::::V::::::::::::::::::::::TF::T::::::R
Hmu2323         ::ES::AD:::G:::::::::::::V::::::::::::::::K::::::::::::::::R

consensus       KVDFLRAIRTYESREESWRRTRAERALALVRAVAERELAEARRVLGRFRDALP-------
#oth            2111..11...13.14..222.12.121...13344.354.2423311124121111111
hla1191         E:E::::::::Q:::::::QA:::::V::::::::V:I:::HA:A::L::R::LDADALA
HQ3332A         :I::::GL:::::::::::QS:TK::V:::::::KT:IED::Q:A::L:EQ:S:::::::
HVO_2315        ::::::G::::::::Q::Q:::T:::VT:::::::V::ED::T:A::L:EQ:::::::::
Hbo2003         ::::::GL:::::::K::Q:::T:::V::::S:::T::::::A:TA:L:EK:::::::::
NP4550A         RI::::::::::A::A::E::::K::A:::::FGD:::::::::V:Q::GSV::::::::
VNG1779         :::L::::::::::AA:::Q:::K::::::::LG-S:VG::::::D::KG::::::::::
Hut0485         :I::::::::::H::D:::Q:::R:::T:::::SD:::HH:KS::R::::S:::::::::
rrnAC1716       :::::::::::QN::D:::T:::::S::::::IEQS::PT:K:M::::::::::::::::
Hmu2323         :I::::::::::H:A::::::::R:::T::::LG-P:ASQ:::I::::::::T:::::::

consensus       ---SGEAEEVEAELDR--D---------------------ESAD
#oth            1114634232433644432312222111111111111111451.
hla1191         AALP:DD:DAVEDRSEDGSPPETATENAGQTPTGERDAEP::::
HQ3332A         :::PTG:R::S:::S:QH:SPTDSV:::::::::::::::D:::
HVO_2315        ::::SG:D::S:::AKRT:::::::::::::::::::::::T::
Hbo2003         ::::AG::::A:::E:QG:T:::::::::::::::::::::A::
NP4550A         :::E::LD:::DPS::D:-:::::::::::::::::::::P:::
VNG1779         :::-DPP:D::::T--::-:::::::::::::::::::::Q:::
Hut0485         ::::R:L:::DVSI:TEH::::::::::::::::::::::PGG:
rrnAC1716       ::::T:R:QLDE:Y--::-:::::::::::::::::::::DL::
Hmu2323         :::RQ:R:A::DDV:-::-:::::::::::::::::::::VV::