[E] (GadB) COG0076 Glutamate decarboxylase and related PLP-dependent proteins 8 genomes BUD0812 8 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG0327 rrnAC1798 HVO_0811 Hbo0722 Hmu0868 Hut0399 hla2705 NP1194A -

Pairwise sequence scores
Consensus score	2701	hla2705	HVO_0811	Hbo0722	VNG0327	NP1194A	Hut0399	rrnAC1798	Hmu0868
2052	hla2705	2830	1940	1810	1743	1730	1802	1700	1794
2135	HVO_0811	1940	2739	2039	1827	1761	1787	1831	1770
2074	Hbo0722	1810	2039	2707	1802	1771	1799	1746	1792
2010	VNG0327	1743	1827	1802	2701	1826	1697	1775	1734
2127	NP1194A	1730	1761	1771	1826	2665	1849	1939	1961
2198	Hut0399	1802	1787	1799	1697	1849	2666	2102	2175
2171	rrnAC1798	1700	1831	1746	1775	1939	2102	2697	2295
2235	Hmu0868	1794	1770	1792	1734	1961	2175	2295	2694

382 symbols
consensus       --------------------MQRAEPQEFDRVLSSMCTEPHPAAREAAERFLATNPGDPG
#oth            1111111111111111222321133..3.2........4...2..2..11.1.......2
hla2705         VQARAPGAERVRPSAVTFGR::QP:::S:::::::::::::::::::::::::::::::A
HVO_0811        ::::::::::::::::::::::::A:::::::::::::R::::::K:::::F:::::::A
Hbo0722         :::::::::::::::::::::::SV::T::::::::::D::::::A:::::::::::::A
VNG0327         ::::::::::::::::MTRGEA:RP:::::::::::::T:::::::::QA:::::::::E
NP1194A         :::::::::::::::::::::::::::::S::::::::::::::::::::::::::::::
Hut0399         :::::::::::::::::::::::::::D:E::::::::::::::::::Q:::::::::::
rrnAC1798       :::::::::::::::::::ML::::::D:E::::::::V:::S:::::::::::::::::
Hmu0868         :::::::::::::::::::::::::::S:E::::::::::::T::K::::::::::::::

consensus       TYETVADLERDAVELLGEITGLPDP---AGYVTSGGTEANVQAVRIARNRADT--DDPNV
#oth            ..221251.22.234.1322113311112..111......2..1.2...132211321.2
hla2705         :::A::S::ER:I:::ATLAEH:T:TDA:::::::::::::::::S::::H:A::S:V::
HVO_0811        ::QA::A::E::LSY::D:::::A::::H:::::::::::I::I:A:::H:RD:::::::
Hbo0722         :::E::E::A::::T::K::::A:::::H::I:::::::::::::A::::SRDRVS:::I
VNG0327         ::PA::ER:::::A:::::V::SS::::H::IAA::::::L::::A::::::A:::AV::
NP1194A         :::::SK:::E::DM:::VA::::A::::::IA:::::::I::::::::::::::RT::F
Hut0399         ::Q::T::::R:::::::::::G:::::T::::::::::::::::::::::E:::T::::
rrnAC1798       ::::I:G:::E:::Y::D::::S:::::::::A:::::::L::I::::::::::::::::
Hmu0868         ::::::::::E:::R::T:A::G::::::::::::::::::::I::::::G:::::::::

consensus       VAPESAHFSFTKAADVLDVELRTAPTD-DYRADVDAVAEAVDDDTVLVVGVAGTTEYGRV
#oth            .1.312....4...13.1....32.33312.2232113312.33.13.1....1..1.2.
hla2705         :V:::G::::H:::EL:::::::V:V:D:F:TRT:::SA::::A:A::::::::::::::
HVO_0811        :::::I::::Q:::::::::::VV:V:D::::N:A::R:::::H::::A:::::::F:::
Hbo0722         ::::::::::N:::::::::::LV:::ETH:::::::RA::::E::::::::::::F:::
VNG0327         :::A::::::Q::::::G::::L::::G:H::::A:::DL::G::AV:::::::::::::
NP1194A         :::A::::::R::::I:G:::::::LE:::::NL:G:::LI:S::A::::::::::::::
Hut0399         :V:D::::::::::EM::::::RI::T:::::::E:M:D:I:::::A:::::::::::H:
rrnAC1798       :::VH::::::::::::G:::::::AA::::VNMA:M::L::E:::C::::::S::::Y:
Hmu0868         ::::H:::::::::EL:G:::::::AT::::::M::MTHLA:::::A:::::::::::Y:

consensus       DPIPALADIAHDAGALCHVDAAWGGFVLPFTDHAWHFAHADVDTMTIDPHKMGQAAVPAG
#oth            ....12123.3421.32.....1...3....122.3.21.312111.....5...31...
hla2705         ::::E:TR:::ET::RM:::::::::::::::GE:S:DD:A:::L::::::F::::::::
HVO_0811        ::::E:TAV:::::::M::::::::::::::::E:S::::P::S:::::::Y:::V::::
Hbo0722         ::::E::A:::::::F::::::::::L::::::::N::::P::SL::::::C:::CI:::
VNG0327         ::::::::::AGVD:NL::::::::::::::::D:S::D:P:N::A:::::::::P::::
NP1194A         ::::::::M:A::::::::::::::::::::E:::D:DD::IH:::::::::::::::::
Hut0399         ::::::::L:DE::::M:::::F:::F:::::F::::G::EI:::::::::A:::V::::
rrnAC1798       :::::I::L:ETVD::::::::::::Y::::::D:::G:::I:::::::::V::::::::
Hmu0868         :::::V::L:DAV:::::::::::::Y::::::D:::G::::::L::::::V::::::::

consensus       GLLARDPDLLDELAIDTPYLESRSQATLTGTRSGAGVASAVAAMDALWPDGYRDQYERAQ
#oth            .1.1.24541.2..11.....132.31.1.........1.2.2122..12...4312243
hla2705         ::::::AAA::A::V::::::T::::::::::::::::G:::::E:::::::::AV:::T
HVO_0811        :::F::KSVV:S::V:::::::A:::S:::::::::::::A:::RE::::::::A:::Q:
Hbo0722         :::F::RNG::S::VE::::::T:::::::::::::::::A::L:E:::::::HE:D:VS
VNG0327         :F:::::ET::A:::E::::::DT:P::G:::::::::G:L:SLR::::::::E::::T:
NP1194A         :::::G:E::::::::::::::T::V::::::::::::::A:V::E::R::::Q:::T::
Hut0399         :F:::SS::::::::::::::::::V::::::::::::::::::E::::E:::R::HASM
rrnAC1798       ::::::RT::::::VE::::::TD:L::::::::::::::::::ES:::A:::Q:::TSM
Hmu0868         :::::S:::::::::::::::::::V::::::::::::::::::::::R::::ET::::M

consensus       ANAEWLADELAARGYDVVDPELPLVAADLPDSEFDALRDRGWRVSRTGSGELRVVCMPHV
#oth            31.311142145..22112.1..11.1221644344..141.1211.42122.1......
hla2705         :::::::SA::E:::E:::::::::::A::R:::::::EA::K::::SH:::::::::::
HVO_0811        :::D::Y:::R:::::A:E::::::::SV::EQ::S:::L:::I:::A:::::I::::::
Hbo0722         DL:S:F:G::RT::F:::::::::::::VSE:T:Q::::HE::I:::D:DL:::::::::
VNG0327         G:::Y::A::::::::::::::::::::M::A::Q:::EE:::I:::A:DA:::::::::
NP1194A         T::H:::A:VES::F:::::V::I::M:::YDLVAD::E::::L:::EAD:A:I::::::
Hut0399         D:::::::A::D:::T::G:::::L:::VSL:LIEQ::::::::TK:::::M::::::::
rrnAC1798       :::D::::Q:S:::H:::G::::::::::SMPMT:E:::::::::K::A::M::::::::
Hmu0868         G::::::EQ:DV::H::IG::::::::::SIPMTTE:::::::::K:::::M::::::::

consensus       TRSMLRSFLADLDWLR------
#oth            1.23.32.13.1.332211111
hla2705         ::EA::A:V::::RI:E:::::
HVO_0811        S:ES:::::S:::N::SGPARN
Hbo0722         ::DT:SA::::::AV:::::::
VNG0327         ::E::AA::D:V:A:A::::::
NP1194A         :::::EE::T:::R:A::::::
Hut0399         ::::::::V:::::Y-::::::
rrnAC1798       ::::::::V:::::Y-::::::
Hmu0868         ::::::::V:::::Y-::::::