[E] (PheA) COG0077 Prephenate dehydratase 9 genomes BUD0319 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG2222 rrnAC2950 HVO_0449 Hbo1058 Hmu2884 Hut1965 hla0270 NP0106A HQ1385A

Pairwise sequence scores
Consensus score	1986	VNG2222	Hut1965	NP0106A	Hbo1058	HQ1385A	HVO_0449	hla0270	rrnAC2950	Hmu2884
1465	VNG2222	2007	1367	1371	1377	1309	1320	1354	1401	1347
1639	Hut1965	1367	1976	1421	1459	1437	1488	1442	1482	1450
1627	NP0106A	1371	1421	1966	1498	1432	1495	1467	1453	1464
1712	Hbo1058	1377	1459	1498	1970	1644	1632	1580	1460	1506
1630	HQ1385A	1309	1437	1432	1644	1969	1546	1491	1396	1418
1709	HVO_0449	1320	1488	1495	1632	1546	1970	1634	1418	1507
1688	hla0270	1354	1442	1467	1580	1491	1634	1984	1458	1496
1574	rrnAC2950	1401	1482	1453	1460	1396	1418	1458	1997	1570
1646	Hmu2884	1347	1450	1464	1506	1418	1507	1496	1570	2004

273 symbols
consensus       MQAVTLGPAGTYSHRAARAVADD--VEFRESVTAIVEAVADGEYERGVVPIENSIEGSVT
#oth            .532....2........3113341113.5..123..31.161221...111....1....
VNG2222         :DT::::::::::::::S::SAGD::S:M:::RD::D:::V:DAD::::::::::Q::::
Hut1965         :RTI::::S::::::::S:LSES:::::T:::::::::::::::D:::I:::::::::::
NP0106A         :K:L::::E::::::::K::T::::I::V::::G:::G::G:::::::::::::::::::
Hbo1058         ::::::::::::::::::::::::::A:::::S:::D::DS:::D:::::::::::::::
HQ1385A         ::I:::::::::::::::::DNN:::G:K:::S:::A::DTE::::::::::::::::::
HVO_0449        ::::::::::::::::::::::::::A::::::S::Q:::::SF::::::::::::::::
hla0270         :N:::::::::::::::::::AE:::S:::::::::D:::A::F::::::::::::::::
rrnAC2950       :TT:::::E::::::::Q::T::D:IS:S:::::::::::N::A::::::V:::::::::
Hmu2884         :KML::::::::::::::S::::DEI:::::P::::::::G::AD::::AV:::::::::

consensus       ESLDALADSD-VAVVREIVTPIRHALLAQSDEFDLVASHAQALAQCRSYLEEHYPDADLE
#oth            .1..13.342121114.11...1.1.1..554.231...2.......42.2331.41641
VNG2222         :T::::::T:GL:::::V:::::::::::D:G::A::::::::::::E::DATH:AV:RR
Hut1965         :::::::::::::::A::I:::::G:M:::ED:::::::::::::::::::::H::::::
NP0106A         ::::::::RN:::I::::::::Q::::::AS:::I::::P:::::::EF:SAE::S:QT:
Hbo1058         :T:::I:EA::I::TQ:::::::::::::TE::SV::::S:::::::::::TE::GVT::
HQ1385A         :T::SI::::::::TQ::::::::::::::S::E:I:::S:::::::::::DT:::VRA:
HVO_0449        :::::V:N::::S::Q::::::::::::::AN::V::::S:::::::T::::N::::K::
hla0270         ::::::::Y:::S:T::::::::::::::GP::EV::::S:::::::NW::::::N:G::
rrnAC2950       :::::F:EY::::::E:VI::::::::::D:S:S:::::::::::::GW:D::::GVNV:
Hmu2884         :::::F:GYE:::::K::I::::::::::RGD:E::::::::::::::::DAN::::K::

consensus       AVASTARGVERAREDPSVAGIGHPDNAGD--DLQVLAEDIQDRSSNATRFFVVAPESERS
#oth            ..........2..4.442.1.1..12223113.612221...22..1...21212432.2
VNG2222         ::::::::::V::N:ETT:A:A:::S:-:GTE:D:HGSG::::A::E::::::G:A:::T
Hut1965         ::::::::::H::::ST::A:A::::::A::E:S::::::::Q::::::::AI:DPQT::
NP0106A         :::::::::::::::::::A:::::T:::::G:::::R::::ST::::::V:L:::T:::
Hbo1058         :::::::::::::::D:::::::::::::::::R:::::::::::::::::::::AA:::
HQ1385A         ::::::::::::::::G::::::::::::::V:A:IS::::::::::::::::::::::V
HVO_0449        :::::::::::::A::T:::::::::V::::::EII::::::Q:::::::L:IG:::A::
hla0270         :::::::::::::::AR::::::::::::::::EI::::::::T::::::L::::::A::
rrnAC2950       :::::::::::::G:ADI:A::::E::TNGTE:K::::::::::::::::V:::SK::::
Hmu2884         :::::::::::::D::::::::::::G:EGT:::::::::::Q:::::::V::::LA:::

consensus       DAGGKSSLIVYPNANYPGLLLELLEPFADRDINLSRIESRPSGERLGDYVFHIDFEAGLY
#oth            41.121131...1211......1..1..1.12..1.2......1.....1..2.331.1.
VNG2222         P::::::I:::::::H::::::::::::::N:::::V:::::::::::::::V:IAS:C:
Hut1965         IE::NT:::::::VD::::::::::::::::V::::L:::::::::::::::::V:::::
NP0106A         E:::::TI:::::T:H::::::::::::E:::::::V:::::::::::::::V::A::::
Hbo1058         ::::::TVV::::::::::::::::A::E::::::::::::::N:::::L::::::::::
HQ1385A         T:::R:TVV::::::::::::::::A:::::::::::::::::N:::::L::::::::::
HVO_0449        ::::::::V::::::::::::::::A::E::::::::::::::N:::::L::::AD::::
hla0270         :::::TT::::::::::::::::::A::::NL:::::::::::::::::L::F:VD::::
rrnAC2950       E::::T:F::::DVD:::::::::::::::::::T:V:::::::::::::::::IS::::
Hmu2884         :::S:::::::::VD:::::::M:::::::N:::T:V:::::::::::::::V:V:::::

consensus       EERTQKALEDVEEIASNGWVRRLGSYDTEHVLE
#oth            .31324.1331241.55...11.....231.23
VNG2222         ::::RN:VA::A:::AA::::::::::::::A-
Hut1965         :Q:L:D::DEI::L::E:::::::::::R::V:
NP0106A         :::::N:::A:RD::GE::::V:::::::::V-
Hbo1058         :D:A:::::S::::::R:::K:::::::Q:::Y
HQ1385A         :S:A:E::KSI:S::TD:::K::::::RR::V:
HVO_0449        :::M:G:::E::G::::::::V::::::R:::Y
hla0270         ::HMA::V::::A::D:::::V:::::::::::
rrnAC2950       :Q:::E::A:I:D::GK::::::::::SKT:VN
Hmu2884         ::::::::A:I:A::EK:::K::::::S:T::N