[K] (RpoB) COG0085 DNA-directed RNA polymerase, beta subunit/140 kD subunit 9 genomes BUD0412 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG2666 rrnAC2430 HVO_0347 Hbo1134 Hmu0144 Hut1476 hla0415 NP0110A HQ3396A

Pairwise sequence scores
Consensus score	3930	VNG2666	NP0110A	HQ3396A	HVO_0347	Hbo1134	hla0415	Hut1476	rrnAC2430	Hmu0144
3607	VNG2666	3933	3483	3479	3478	3483	3508	3526	3519	3464
3669	NP0110A	3483	3926	3474	3529	3535	3590	3535	3558	3575
3636	HQ3396A	3479	3474	3953	3566	3639	3540	3491	3485	3483
3673	HVO_0347	3478	3529	3566	3912	3667	3566	3482	3494	3481
3660	Hbo1134	3483	3535	3639	3667	3942	3615	3497	3520	3542
3715	hla0415	3508	3590	3540	3566	3615	3946	3534	3625	3590
3662	Hut1476	3526	3535	3491	3482	3497	3534	3928	3649	3613
3730	rrnAC2430	3519	3558	3485	3494	3520	3625	3649	3943	3687
3693	Hmu0144	3464	3575	3483	3481	3542	3590	3613	3687	3937

527 symbols
consensus       MNRQDRRAVSREYFSRERLAEHHFRSFNAFLDRGMQDVVDEKETIETDIGDKEGEEPVWV
#oth            .23221.42.13..141.........1.2..11..12..3..12.1.......11...3.
VNG2666         :LQE:K:EL:ES:::K::::::::::Y::::EH::::::T:::R:::::::::D::::::
NP0110A         :::E:::S::::::::::::::::::::N::::::::::::::S:D::::::::Q:::R:
HQ3396A         :::E:::T:::::::ED:::::::::::N::E:::::::T:::R::::::::::::::F:
HVO_0347        ::::A::E:::K:::E:::::::::::::::E:::M:::E::A:::::::::::::::Y:
Hbo1134         :::::::::::Q:::Q::::::::::::N::E::::E::S::A::D::::::::::::Y:
hla0415         :::::::V:::::::D::::::::::::N:::::::E:::::::::::::::::Q:::Y:
Hut1476         :DTEN::TI:::::::D:::::::::::::::::::E:::::A:::::::::::::::::
rrnAC2430       :DT:::::I:::::AK::::::::::::::::::::Q:::::::::::::::::Q:::::
Hmu0144         :DVN::::I:::::::::::::::::::S:::::::Q:::::::::::::::::Q:::F:

consensus       ELGDVRIVTPRVREADGSEELLYPQEARLRNITYSAPVFMEMSIVRGGEEEEEVVVDTTE
#oth            1..21.31..............1...1.......1.......1.11..11.2.3.1.31.
VNG2666         ::::::A::::::::::::::::::::::::::::::::::::::::::::::R:L::::
NP0110A         D::N::::::::::::::::::::::::::::::::::::::::::::D::::Q:::QA:
HQ3396A         :::::::E::::::::::::::F:::::::::::A:::::::::::::D::Q:::::N::
HVO_0347        :::G::VE::::::::::::::F:::::::::::::::::::::::::::::::::::A:
Hbo1134         ::::I::E::::::::::::::F:::::::::::A:::::::::I:::::::::::::::
hla0415         ::::::M::::::::::::::::::::::::::::::::::::::::::D:P:Q::::::
Hut1476         ::::::::::::::::::::::::::::::::::A:::::::A::K:::::::R:::Q::
rrnAC2430       ::::::V:::::::::::::::::::::::::::::::::::A::::::::P:E:::R::
Hmu0144         ::::::V:::::::::::::::::::G:::::::::::::::A:::::D::::::::Q::

consensus       TKVGRMPIMVGSNKCNIAGFSDEELIDIGEDPADPGGYFIVNGSERVLMTSEDLAPNKIL
#oth            ..1....1....4...12312.11.11.....1......21...................
VNG2666         ::::::::::::D::::S::::::::E:::::::::::::I:::::::::::::::::::
NP0110A         :::::::V::::::::::D:N:::::E:::::::::::::::::::::::::::::::::
HQ3396A         ::::::::::::T::::::LT:::::::::::V:::::::::::::::::::::::::::
HVO_0347        ::::::::::::S:::::EL:::D:VE:::::V:::::::::::::::::::::::::::
Hbo1134         ::::::::::::S::::SNLT::::VE:::::V:::::::::::::::::::::::::::
hla0415         ::::::::::::::::M:::::D:::::::::V:::::::::::::::::::::::::::
Hut1476         ::::::::::::Q:::::::::::::::::::::::::::::::::::::::::::::::
rrnAC2430       ::I:::::::::::::::::T::::::::::::::::::C::::::::::::::::::::
Hmu0144         ::I::::::::::::::D::T::::::::::::::::::V::::::::::::::::::::

consensus       AEYDTKYGDEIQVAKTFSQRRGYRALVLCERNREGLLEVSFPSVSGSINFVTLVRALGLE
#oth            ..1.1....11.1...............2..1.2.1...........13...........
VNG2666         ::::S:::::::::::::::::::::::V:::::::::::::::::::S:::::::::::
NP0110A         ::::::::::::I::::::::::::::::::::N:I::::::::::::::::::::::::
HQ3396A         ::::S::::::::::::::::::::::::::::::::::::::::::VE:::::::::::
HVO_0347        :::::::::::::::::::::::::::::::::::::::::::::::V::::::::::::
Hbo1134         :::::::::::::::::::::::::::::::::::I:::::::::::VE:::::::::::
hla0415         ::::S:::::::::::::::::::::::::::::::::::::::::::D:::::::::::
Hut1476         ::::::::::V:::::::::::::::::T::T:D:::::::::::::V::::::::::::
rrnAC2430       ::::::::::V::::::::::::::::::::T:D::::::::::::::D:::::::::::
Hmu0144         ::H::::::DV::::::::::::::::::::T:D:I::::::::::::::::::::::::

consensus       SDEEIVHRVSDDPEIVKFMLENLEEAEVQTTEEAIETLGKRVASGQGKNYQLKRANYVID
#oth            .......1..1......1......1.2...222...3..2...2................
VNG2666         ::::::::::E:::::::::::::::D:::Q:::::D::Q::::::::::::::::::::
NP0110A         :::::::::::::::::Y::::::A::::::S:::::::Q:::A::::::::::::::::
HQ3396A         ::::::::::::::::::::::::::S:::E:::::::::::::::::::::::::::::
HVO_0347        ::::::::::::::::::::::::::::::Q:Q:::A::::::G::::::::::::::::
Hbo1134         :::::::::::::::::Y::::::::::::EA::::S:::::::::::::::::::::::
hla0415         ::::::::::::::::::::::::::::::::G::::::E::::::::::::::::::::
Hut1476         :::::::Q::::::::::::::::A:::::Q::::::::Q::::::::::::::::::::
rrnAC2430       ::::::::::E:::::::::::::::::::::::::::::::::::::::::::::::::
Hmu0144         ::::::::::::::::::::::::A:D:::::G::::::E::::::::::::::::::::

consensus       RYLLPHLHEEGVEEEEVRINKAYYLCRMAEACFELALGRRESDDKDHYANKRLKVSGDLM
#oth            .........1.211.21.1...2..............3..11......1...........
VNG2666         :::::::::D::::::T::::::::::::::::::::::::A::::::::::::::::::
NP0110A         :::::::::::::D::::M:::V:::::::::::::::::::::::::::::::::::::
HQ3396A         :::::::::D:I:::A:::::::::::::::::::::D::::::::::::::::::::::
HVO_0347        :::::::::::A::::::M::::::::::::::::::Q::D:::::::::::::::::::
Hbo1134         :::::::::D::D::D::::::F::::::::::::::E::D:::::::::::::::::::
hla0415         ::::::::::::D::D:::::::::::::::::::::E:::A::::::::::::::::::
Hut1476         :::::::::::ID:::T::::::::::::::::::::D::::::::::::::::::::::
rrnAC2430       ::::::::::::::::::::::F:::::::::::::::::::::::::::::::::::::
Hmu0144         ::::::::::::D::D::::::F:::::::::::::::::DA::::::S:::::::::::

consensus       KDLFRTALNKLARDVKYQLERANMRNRQLTVSTVVRSDVLTERLEHPIATGNWVGGRSGV
#oth            2..........1...............3.1.1............................
VNG2666         :::::::::::::::::::::::::::E:::N::::::::::::::::::::::::::::
NP0110A         :::::::::::S:::::::::::::::D:S::::::::::::::::::::::::::::::
HQ3396A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HVO_0347        :::::::::::::::::::::::::::N:::N::::::::::::::::::::::::::::
Hbo1134         :::::::::::::::::::::::::::::::N::::::::::::::::::::::::::::
hla0415         R::::::::::::::::::::::::::D:::N::::::::::::::::::::::::::::
Hut1476         R::::::::::::::::::::::::::::S::::::::::::::::::::::::::::::
rrnAC2430       T::::::::::::::::::::::::::::S::::::::::::::::::::::::::::::
Hmu0144         :::::::::::::::::::::::::::::S::::::::::::::::::::::::::::::

consensus       SQLVDRTDYMGVLSHLRRLRSPLSRSQPHFEARDLHATQWGRICPSETPEGPNCGLVKNF
#oth            ........1.....................1.............................
VNG2666         ::::::::F:::::::::::::::::::::::::::::::::::::::::::::::::::
NP0110A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HQ3396A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HVO_0347        ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo1134         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
hla0415         ::::::::::::::::::::::::::::::K:::::::::::::::::::::::::::::
Hut1476         ::::::::F:::::::::::::::::::::::::::::::::::::::::::::::::::
rrnAC2430       ::::::::F:::::::::::::::::::::::::::::::::::::::::::::::::::
Hmu0144         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       AQAMELSQNVEDEQDLKRELASMGVEGIPGI--ESVDQQ----PADD
#oth            ........412.115..11.12...2111211123435421112...
VNG2666         ::::::::D:D::R:::Q::S::::::::::SM:TTSTT::::S:::
NP0110A         ::::::::S::::RR:::::::::::::::::::T:ETH::::T:::
HQ3396A         ::::::::::::::S:::::S::::DIFHTS::T:T:DTDTRS::::
HVO_0347        ::::::::::::::S::::::::::::::::::D:::AA::::::::
Hbo1134         :::::::::I::::A:::::::::::::::::::GP:PTNT::::::
hla0415         ::::::::T:D:::G:::::::::::::::::::G::R:::::T:::
Hut1476         ::::::::H::::RE::QT::E:::Q:::A::::TAA::::::::::
rrnAC2430       ::::::::D:S:P:G::Q:::E:::Q:::::::::IE::::::::::
Hmu0144         :::::::::::::::::Q:::D:::Q::::::::RIE:-::::::::