[E] (HisF) COG0107 Imidazoleglycerol-phosphate synthase 9 genomes BUD0547 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG0862 rrnAC1394 HVO_1044 Hbo0539 Hmu1902 Hut1319 hla2747 NP4158A HQ1695A

Pairwise sequence scores
Consensus score	2044	VNG0862	hla2747	Hut1319	HQ1695A	HVO_1044	Hbo0539	NP4158A	rrnAC1394	Hmu1902
1726	VNG0862	2080	1558	1614	1640	1659	1645	1657	1699	1728
1795	hla2747	1558	2059	1711	1647	1675	1664	1709	1727	1728
1819	Hut1319	1614	1711	2042	1698	1752	1757	1688	1752	1733
1798	HQ1695A	1640	1647	1698	2034	1776	1750	1671	1716	1740
1883	HVO_1044	1659	1675	1752	1776	2052	1927	1748	1765	1779
1844	Hbo0539	1645	1664	1757	1750	1927	2052	1730	1750	1765
1834	NP4158A	1657	1709	1688	1671	1748	1730	2051	1752	1793
1881	rrnAC1394	1699	1727	1752	1716	1765	1750	1752	2035	1842
1911	Hmu1902	1728	1728	1733	1740	1779	1765	1793	1842	2042

275 symbols
consensus       MTLTKRIIPCIDVDLDEDGNAAVYTGVNFEDLEYTGDPVEMAKKYNEAGADEFVFLDITA
#oth            13....1.......1121.21.....1...2.3.......1..5..21............
VNG0862         ::::::V:::::::::D::EP:::::::::E:A::::::::::R::::::::::::::::
hla2747         :G::::::::::::::A::D::::::::::N:::::::::L:::::A:::::::::::::
Hut1319         ::::::::::::::::::::::::::::::::Q::::::::::E::::::::::::::::
HQ1695A         -M::::::::::::::::::P:::::I::::::::::::::::Q::M:::::::::::::
HVO_1044        -M::::::::::::::::::P:::::::::::K::::::::::L::::::::::::::::
Hbo0539         -M:::::::::::::N:::EP:::::::::::Q::::::::::L::::::::::::::::
NP4158A         :A:::::::::::::N:::E::::::::::::::::::::L:::::::::::::::::::
rrnAC1394       ::::::::::::::V::N:D:::::::::::::::::::::::A:::S::::::::::::
Hmu1902         :::::::::::::::::::D::::::::::::A::::::::::::::S::::::::::::

consensus       SAEGRETMLDTVSAVADEVFIPLTVGGGIRTRDDIKETLRAGADKVSINTGALARPDLIE
#oth            ..2......11.23....2...........122..11...........111.124.2.14
VNG0862         ::::::::::::::::::::::::::::::DT:::R:::::::::::::S::I:D:S:VD
hla2747         ::::::::::V:N:::::C::::::::::::KA:::::::::::::::T::::E::E:::
Hut1319         ::D:::::::::ER:::::::::::::::::KA:::::::::::::::::::IEN:::::
HQ1695A         ::V::::::E:::R::::I:::::::::::::::::S:::::::::::::A::ET:E::T
HVO_1044        :::::::::::::K::::::::::::::::::::::::::::::::::::A::QN:::::
Hbo0539         :::::::::::::R::::::::::::::::::E:::::::::::::::::A::QN:::VN
NP4158A         ::::::::::::::::::C::::::::::::::::::::::::::::::::::Q::E::G
rrnAC1394       ::::::::::::::::::::::::::::::::A::::::::::::::::S::I:E::::N
Hmu1902         :::::::::::::Q::::::::::::::::::E::::::::::::::::S::I:::E::G

consensus       EGAAAFGSQCIVISVDARRRFDEAGEH-YAEVDGESCWFECTVKGGREGTGIDVVEWATE
#oth            3..51..1......1.....1.22.121.432...11...1.21......14.121.17.
VNG0862         R::K:::::::::::::::::::Q:Q:::TQ::::::::::::H:::::::M:AI::VQ:
hla2747         ::::::::::::::I:::::Y:D::::F:EDD:::TV:::::K::::::::::A:S::K:
Hut1319         A::T:::N::::::::::::Y:::::Y::EQI::::V:::A::::::::::M:::::VR:
HQ1695A         T::S:::::::::::::::::::Q::N::LS:::::::::::::::::::::::L::V::
HVO_1044        :::RS::::::::::::::::::::::::::::::::::::::::::::::V::::::N:
Hbo0539         :::R::::::::::::::::Y:::::Y:::::::::::::::::::::::D:::::::S:
NP4158A         :::E:::::::::::::::::::::::::V::::::::::::I::::::::T::::::G:
rrnAC1394       ::::::::::::::::::::::SE:::::T:::::::::::::::::::::L::I:::::
Hmu1902         :::::::::::::::::::::::Q::::::D::::::::::::::::::::L::::::I:

consensus       AEDRGAGELFVNSIDADGTKDGYDIPLTKAVCDAVSTPVIASSGCGSPEDMYEVFTEAGA
#oth            .25.......1....1...1....1..13..114.2..........2.21.411131.2.
VNG0862         :QR::::::::::::::::Q::::V:::A:::::::::::::::::A:G::ADAY-D:::
hla2747         ::E::::::::::::K:::::::::::M::::::::::::::::::::::::D:::::N:
Hut1319         ::::::::::::::::::::::::::::R::TEN:D::::::::::G:::::::::D:::
HQ1695A         ::T:::::::I::::::::Q::::::::S:::::::::::::::::::A::H::::::::
HVO_1044        ::S:::::::I::::::::::::::::::::::S::::::::::::G::::C::::::::
Hbo0539         ::S:::::::::::::::::::::V::::::::E::::::::::::G:::::::::::::
NP4158A         :A:::::::::::::::::::::::::::::::N:P:::::::::::::H:A:::ED:D:
rrnAC1394       ::E::::::::::::::::::::::::M:::::T:::::::::::::::::E:::VD:::
Hmu1902         ::Q:::::::::::::::::::::::::S::::::::::::::::::::::::::E::::

consensus       DAGLAASIFHFDEYSIAETKEYLDERGVPVRL---
#oth            ..1........21.1.421.33.12412.1.3111
VNG0862         ::A::::::::::::::::::T:ADA:Y:I:APDA
hla2747         :::::::::::GD:::E:::K::::::::::::::
Hut1319         :::::::::::G::::T::::::::::::::::::
HQ1695A         :::::::::::G::::EA:::::::::::I:T:::
HVO_1044        ::::::::::::::T:RDV:::::::D::::::::
Hbo0539         ::::::::::::::::QDV:::::D:D::::F:::
NP4158A         ::A::::::::E::::E:::RS:::Q:I:::::::
rrnAC1394       :::::::::::G::::::::::::SK:I:::::::
Hmu1902         ::::::::::::::::::::QR:::M:::::::::