[L] (AlkA) COG0122 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase 9 genomes BUD0511 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG1266 rrnAC1166 HVO_1681 Hbo3157 Hmu1455 Hut1513 hla1750 NP3754A HQ2577A

Pairwise sequence scores
Consensus score	2368	VNG1266	Hut1513	NP3754A	HQ2577A	HVO_1681	hla1750	Hbo3157	rrnAC1166	Hmu1455
1507	VNG1266	2355	1285	1285	1184	1444	1331	1383	1295	1286
1719	Hut1513	1285	2387	1485	1385	1520	1562	1495	1544	1576
1709	NP3754A	1285	1485	2336	1387	1499	1465	1546	1482	1387
1683	HQ2577A	1184	1385	1387	2585	1504	1442	1649	1380	1375
1942	HVO_1681	1444	1520	1499	1504	2364	1719	1768	1674	1634
1886	hla1750	1331	1562	1465	1442	1719	2587	1819	1528	1579
1956	Hbo3157	1383	1495	1546	1649	1768	1819	2379	1484	1515
1747	rrnAC1166	1295	1544	1482	1380	1674	1528	1484	2334	1734
1768	Hmu1455	1286	1576	1387	1375	1634	1579	1515	1734	2363

345 symbols
consensus       --------------------------MERGAIDLASLAGAFDLQATLESGQSYLWDRADG
#oth            12222222222222222222222122133.42335333.23.1.2.1....111.4.4.1
VNG1266         ::::::::::::::::::::::::::::::::P:DDVP::V:V::::::::T:::W:P::
Hut1513         :::::::::::::::::::::::::::H::TLS:P:V-:P::::S:V:::::FR:V:E::
NP3754A         :::::::::::::::::::::::::::DT:SRPI:AFD:GL:::T::::::::::R:E::
HQ2577A         MGLDNQTKRQYTLRVWISSMDYSG::F:S:::::RDI::P:::::::::::::::N:::S
HVO_1681        ::::::::::::::::::::::::::::T:V:::G::D::::::S::::::::::::P::
hla1750         MAVHELAVIGSHRPKPEYGFGATGSI:::::::V:N:::P::::::V::::::::N::::
Hbo3157         ::::::::::::::::::::::::MEF:T:::P:SDID::::::::::::::::::::::
rrnAC1166       ::::::::::::::::::::::::::::Q:V::VG::::GI:::::V::::::::::D::
Hmu1455         :::::::::::::::::::::::::::Q::Q:AT:::P:GV:::S:V::::::::::S::

consensus       RMYEDDGAYGGDAWYETVVPPIDGVSD-EPAVIRVRQ----RDGRLEWEATT-DAVPILR
#oth            31.343624.122..5.13346426651365121..11111432511.223411142612
VNG1266         DT:RT::LS::::::R::I--------:DDD::D:::::::TATAI::RG:::::A::V:
Hut1513         :T::::E::::::::A:::GGDE:ADAPTTG:V::::::::I:D::::::SF:::EET::
NP3754A         :::D:AP:E:A--::Y::L:ATATETN:::E:L:::S::::VGD::::A:S:PN:YER:E
HQ2577A         G::DSMSVS::SN:::::A:::::I:::T:I:::::::::::EDQ::::::G::P:EV:T
HVO_1681        ::::R:A:H::::::Q:::::L:::::::S::V::::::::T::A::::SNV:::::L:T
hla1750         :T:::LH::::::::::::D::P::V:::R:L:::::EGGV:::T:H::SSV:::::L:E
Hbo3157         ::::SMDV:::::::::::::::::::::Q::V::::::::T:::::::::::::::::T
rrnAC1166       K::QR:::T::::::W:T:-RR::SPE:---::::::::::Q::M::::S:V:::EAD::
Hmu1455         :::DQ:::H::S:::W:T:-RV::RAH:---:::::::::::::H::::SDI:::T:H::

consensus       HLLRLDDDLDAIRDATPDDPLVTRAYDAYWGMRLVRDPPFGCLISFICSAQMRVSRIHGM
#oth            3211.1...411443311241254.32325.1.112..2.32.11........13..14.
VNG1266         DA:G:H:::::V:G:ARS:::I:A:W:::D:L:I::::F::::V::::::::::E::FE:
Hut1513         RR:::::::P:::A:::::::LDA:F:R:::L::::::::AT::A::::::::IG:::E:
NP3754A         A:::::::::::FE:::::::::S::::HR:L:::C:::::T::::::::::::::::D:
HQ2577A         :::::::::TS:Y:SF:::E:::T:VG:FH:L::::::::ST::::::::::::::::Q:
HVO_1681        ::::::::::::VSEM::E:::R:::E::P:::::::::::::V:::::::::::::F::
hla1750         ::F:::::::::L:::::L::LK::::::E::::T:::V:P:::::::::::::A:::::
Hbo3157         ::::::::::::L::::::S:LE::::::E::::::::::P:::::::::::::::::::
rrnAC1166       R::::::::A:::STA:::DV:QS::ETF::::::Q:::::S::::::::::::A:::S:
Hmu1455         R::::::::E:::ATA:::AV:QD:::E:::::::::::::S::::::::::::G:::::

consensus       QRALREAYGETVTFDGETYHAFPTPSQLAAATEDALRDLSLGYRAPYVQRTAEMVANGEA
#oth            .6212231.252212.422612.1132..331.33....2........2...2.114.31
VNG1266         :ER::RE::TPI::::Q:VYSV:E::A::::::SD::::K::::::::::::A:::S::L
Hut1513         ::::E:RF::S:::::VE:::::::AR::E:::AD::::G::::::::::::::::E:T:
NP3754A         :A::AD::::::V:::TE:T::::::A::::S::::::::::::::::::::::::::D:
HQ2577A         :LSMAD:F:T:H:VG::SFA::::::::::QS:S:::::::::::::::::::::ST:::
HVO_1681        :SR:::T:::R:E::::::F:Y:::ER::E::::E:::::::::::::R:::::::T:::
hla1750         ::R:::T::DA::V:::E:R:::::D:::SR::SE:::::::::::::::::::I:S:::
Hbo3157         :MR:ARE::D:::VA:::::::::AD:::VR:::E:::::::::::::::::::::::D:
rrnAC1166       :Q:::D:F::E:E:G:R::S:Y::::A::ET::ER::::G::::::::::::::::G:::
Hmu1455         :Q::::T::DP::::::::::Y:::E::::T::A:::::G::::::::L:::T:::E:K:

consensus       HPAEAVGLAYEDARESLTQFVGVGDKVADCVLLFSLGYLEAVPLDTWIRTAIEEHYPDCD
#oth            216314323..4..141.4.....2..1........1122.......1211.1111.312
VNG1266         TKRDID:R:::L:::TM:D:::::N::::::::::::::A:::::::MQ::::D:::::E
Hut1513         ::Q::TD::::::::Y::::::::E::::::::::::FV::::::::::ST:::Y::E::
NP3754A         ::TD:::::::A::::::R:::::E::::::::::::::::::::::::::::D:::::A
HQ2577A         :::I:AER:::N:::Y::::::::N:::::::::::D:T:::::::::Q:::A::F:A::
HVO_1681        T::::R:RD::::::F::T:::::::::::::::::D::::::::::::S::::::::::
hla1750         D:R::AN:P::E::::::K::::::::::::::::::F::::::::::::T:::Y::::E
Hbo3157         ::ND::::P:::::D::::::::::::S:::::::::F::::::::::Q:::AD:::::E
rrnAC1166       D:E:::::D:::::::::R:::::::::::::::::D:::::::::::::T:::Y::E:E
Hmu1455         D:HA:REMV::E::DH::::::::::::::::::::DF:Q::::::::K:T:::YF:TA:

consensus       RGNYADTSRAIRERLGGEYAGYAQTYVFHYLRSGGE---------
#oth            113.32....1.331.232...1...1.12..4.24542222111
VNG1266         ::R:E:::::F::H::-PH:::T:::L::::::::SAPEPTE:::
Hut1513         ::S::E::::::::F::Q:::::::::::H::N::GSAE::::::
NP3754A         ::::::::::::RQF:N:::::T::::::H::T:D-:::::::::
HQ2577A         :DG:MQ::::::D::::Q::::::::::Y:::G:::VSSADTANL
HVO_1681        :::::::::::::::::R::::T::::::::::::::::::::::
hla1750         ::::T::::::::QF:::F:::::::::YH::A::::::::::::
Hbo3157         A:::TE::::::D::::Q::::::::::Y:::A::::::::::::
rrnAC1166       ::::::::::::GA::::::::T:::L:::::T:SNED:::::::
Hmu1455         :::::::::::::A:::::::::::::::F::::::PA:::::::