[J] (TruB) COG0130 Pseudouridine synthase 9 genomes BUD0369 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG1729 rrnAC3342 HVO_2493 Hbo2191 Hmu2131 Hut3040 hla1427 NP4916A HQ2764A

Pairwise sequence scores
Consensus score	2202	VNG1729	HQ2764A	NP4916A	Hut3040	hla1427	HVO_2493	Hbo2191	rrnAC3342	Hmu2131
1666	VNG1729	2308	1437	1398	1518	1488	1426	1502	1357	1372
1612	HQ2764A	1437	2549	1285	1372	1435	1454	1549	1297	1354
1607	NP4916A	1398	1285	2243	1536	1350	1410	1496	1375	1419
1756	Hut3040	1518	1372	1536	2263	1508	1521	1629	1476	1547
1741	hla1427	1488	1435	1350	1508	2644	1603	1658	1430	1504
1787	HVO_2493	1426	1454	1410	1521	1603	2190	1742	1472	1510
1899	Hbo2191	1502	1549	1496	1629	1658	1742	2190	1584	1518
1664	rrnAC3342	1357	1297	1375	1476	1430	1472	1584	2371	1602
1666	Hmu2131	1372	1354	1419	1547	1504	1510	1518	1602	2302

385 symbols
consensus       -----------------------------MRLRGPPDDRSPADLLSFGVVNLDKPPGPSA
#oth            11111111111222222222222223323463.51.34.1244224...2.1...2...1
VNG1729         ::::::::::::::::::::::::::::::GI:P::GE::::AV::::::::::::::::
HQ2764A         :::::::::::::::::::::::::MTESP:::ES::N::L::ICN:::::::::V::::
NP4916A         :::::::::::::::::::::::::::::::E::::A::D:ET::E:::I::::::::::
Hut3040         ::::::::::::::::::::::::::::::A:::::E:::::E::::::L::::::::::
hla1427         MTRHSDDTDANTGADTGRDADADADGDAVDP::S:::Q::VPE::R:::::V:::A:::S
HVO_2493        :::::::::::::::::::::::::::::-M::D::EH::VG::::::::::::::::::
Hbo2191         ::::::::::::::::::::::::::::VTD:::::::::LD::::::::::::::::::
rrnAC3342       :::::::::::MATRGRHRSRTSGTSSEP:T::A:::E:DLDS:R:::::::::::::::
Hmu2131         :::::::::::::::::::::::::::::-MV:DS:EH:::::::T::::::::::::::

consensus       HQVAAWVRDA------------AGVERAAHAGTLDPKVTGCLPVLLGDATRMAQVFLEGS
#oth            ..121.1..2222212222211533331..2............3.1.2.1.3.2111225
VNG1729         :::S::I::L::::::::::::V:::K::::::::::::::::::T:T:::I:PAL:::F
HQ2764A         :::S:::::L::::::::::::I::::::::::::::::::::I:::E:::L:P:::::T
NP4916A         :::::::::M::::::::::::::::Q::::::::::::::::::T:T:::A::::D:SR
Hut3040         :::::::::L:::::::::::::T:::::::::::::::::::M::::::::::::DDSD
hla1427         ::LS::::::INETLATLDPDGSPIHGV:::::::::::::::T:T:::::A::::::::
HVO_2493        :::TG::::M:::::::::::::D:D::::S::::::::::::T::::::::::::::::
Hbo2191         :::::::::M:::::::::::::::::::::::::::::::::M::::::::::::::::
rrnAC3342       ::::::I:::::::::::::::T:QD:V::G::::::::::::::::::A::::::DNAV
Hmu2131         ::::::::::VDDALDAAGDD:RTLG:V::G::::::::::::I:::::A:A:R::DDAV

consensus       KEYVAVLELHG--PAPSDLESVVAEFEGEIYQKPPRKSAVSRRLRSRTIHDLDVLEVDD-
#oth            .1.121..1.311521322532222.1342.....1....4.1..3.2124..2.14431
VNG1729         ::::::::::D::DP:RI:PD:IEA:T::::::::K::::A::::T::VY:::::D::G:
HQ2764A         :::L::::F:::::P::::SMIIET:::T::::::::::::::::K:::ET::I::::SD
NP4916A         :G:::::::::::T:::::::T::::::PL::::::::::A::::T::V:R:::::SEA:
Hut3040         ::::::::::ERLAD::T::A:AD:::::::::::K::::V::::::E::R:::::AE::
hla1427         ::::S::::::::SP:A:FRD::::::A::::::::::::T::::T:::Y::::::::::
HVO_2493        ::::S::::::::::SA:ID:T:::::SKL:::::::::::::::V:E:::::L:::K::
Hbo2191         ::::S:::::K:::::::::::::::::DV:::::::::::::::::EVY:::L:::E::
rrnAC3342       ::::T:::::D::Q::A:IADI:::::TD:::::::::::K:Q::::R::S::I::QG::
Hmu2131         ::::TI::::D::Q::P:FD:I::::::::::::::::::K:::::::::A:::::RH::

consensus       -RQALLRIRCESGTYIRKLCHDIGLALGTGAHMGHLRRTATDPFDDRDLVTLHDLVDALA
#oth            1112..111.2....1......2.1.3.111...3...22.23.1.33.4234.14.112
VNG1729         :::V::::::::::::::::::::R::::N::::::::S::T::::T::::::::A::V:
HQ2764A         AQ::::::::::::::::::::L:::A:::::::D::::G:T::S:TN:ISTA::T::VV
NP4916A         ::RV::SVE:::::::::::::::::V:::G:::P::::K:GG::::T:::FE:FA:G::
Hut3040         ::R:::S:::::::::::::::M:::::::::::D:::A:::::::A::::M::F:::::
hla1427         ::::::::::::::::::::::::::T:V::::::::::::::::::::HP:Q::::G:T
HVO_2493        ::::::::::::::::::::::L:::::::G:::::::::::::::A::A:::::K::::
Hbo2191         ::::::::::::::::::::::::::A:::::::::::::::::::T:::::Y::S::::
rrnAC3342       ::RL:::V::A:::::::::::::::A:::::::D::::::GT:::GS:S:M::::::::
Hmu2131         ::R::::V::G::::V::::::::::::::::::E::::::GD::::::::ME:::::::

consensus       -FAREG-------------DDS-P-----------------------LREVVAPAERALS
#oth            1134341111111111111.133611111111111111112221212.23313...1..5
VNG1729         :WL:DT:::::::::::::::TE:::::::::::::::::PDAPADA::AA:Q::::::T
HQ2764A         ::TL:EIVRANQTQINDAP:::TAAYSLLHKINTANIDPNSTSPTDH::N:IS::::::Q
NP4916A         ::W:DH:::::::::::::::PEL::::::::::::::::::::::::CD:::::::::E
Hut3040         :WW::D:::::::::::::::PD:::::::::::::::::::::::::::::Q::::::V
hla1427         :W:E:::::::::::::::::A:F::::::::::::::::::::::::::::R:::D::V
HVO_2493        :::A::::::::::::::::E::W:::::::::::::::::::::::::D::S:::::::
Hbo2191         :::EQ:::::::::::::::E::V:::::::::::::::::::::::::D::::::::::
rrnAC3342       :::AD:::::::::::::::EA:Q::::::::::::::::::::::::::IIQ:::::::
Hmu2131         EWTDND::::::::::::::ET:W::::::::::::::::::::::::H:T::::::::A

consensus       HLPRVTIAPSAAREVAEGAPVYAPGVIDTDAAAAGDA------------LVACYTPDGAA
#oth            21.3111.4...431.4...1.....324344665641111112332532.31312212.
VNG1729         ::::L:::D:::H:::T::::::::::::T:LPTPP::::::::::DGA::::::AG:T:
HQ2764A         :::T:I::::::A:::M::::::::::EF:S::GNTH::::::DITDSA::S:H:::ET:
NP4916A         G:::L:V:F:::S:I:N:::::::::LAHELDG:DE-::::::::::GS:::::::::::
Hut3040         D::S::::::::ES::::::I:::::::A:DDLDPA:::::::::::EP:::::I:N:::
hla1427         :::S:::::::::N::T:::::::::::V:SVSE:GEGDDGDDTDRDPP::::H::::::
HVO_2493        :::S::::N:::::::N:::::::::F:V::D::RGD::::::::::::::::F:D::S:
Hbo2191         :::H::::Y:::EQ::::::::::::SEA:D:ER:S-::::::::::::::::V::::::
rrnAC3342       :::::::::::::::::::::::::::E:GP:EV:::::::::TPEIDSQ:VSV::::::
Hmu2131         GY:T::::::::::::H::::::::::E:::EQGA:-::::::::::::-:C:V::::::

consensus       VCLGRLVGDPDADSGEVVELERVLV
#oth            ....312112..23.3122.111..
VNG1729         :::::::::::::A:V::A::::::
HQ2764A         :::::VS:PL::E::::IS::::::
NP4916A         ::::W:::::::AD:T:A:::::::
Hut3040         ::::T:A::::::E:T:::::::::
hla1427         ::::::::::::E::V::S::::::
HVO_2493        ::::E::::A::::::::S::A:::
Hbo2191         ::::::::::::E:::::S::::::
rrnAC3342       ::::T::S:::::::L::::D:M::
Hmu2131         :::::::::::::::VA::::::::