[E] (Asd) COG0136 Aspartate-semialdehyde dehydrogenase 9 genomes BUD0644 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG1435 rrnAC0365 HVO_2487 Hbo2387 Hmu1299 Hut1459 hla1528 NP1988A HQ2908A

Pairwise sequence scores
Consensus score	2599	VNG1435	Hut1459	HQ2908A	HVO_2487	Hbo2387	hla1528	NP1988A	rrnAC0365	Hmu1299
1967	VNG1435	2592	1656	1763	1838	1786	1821	1875	1719	1599
2032	Hut1459	1656	2519	1775	1843	1851	1793	1872	1858	1827
2135	HQ2908A	1763	1775	2570	2035	2105	2013	1905	1837	1696
2251	HVO_2487	1838	1843	2035	2600	2155	2091	1944	1894	1754
2241	Hbo2387	1786	1851	2105	2155	2673	2124	1932	1904	1784
2228	hla1528	1821	1793	2013	2091	2124	2605	1964	1878	1804
2144	NP1988A	1875	1872	1905	1944	1932	1964	2599	2020	1877
2090	rrnAC0365	1719	1858	1837	1894	1904	1878	2020	2592	2029
1960	Hmu1299	1599	1827	1696	1754	1784	1804	1877	2029	2452

358 symbols
consensus       ---------MTVRVGILGATGAVGQRFIQLLDPHPTFELAALTASEASAGKTYREAAKWR
#oth            11111111224231121111111111222..33.32.121111..44.1.24.42..1.1
VNG1435         :::::::::-MTT::V:::::::::::V:::AG:E::::SVV:::PD:::E:::D::N:G
Hut1459         :::::::::-------------::::LV:::::::D::I:::::::N:::TS::::::::
HQ2908A         ::::::::::::::::::::::::::::K::TN:D:::::::::::S:V::Q:SN:::::
HVO_2487        ::::::::::A:::::::::::::::::::::D:::::::::::::E::::R:D::::::
Hbo2387         MGVPRKNTA:::Q:::::::::::::::::::G::::::::::::::::::::A::::::
hla1528         ::::::::::S:::::::::::::::::::::D::::D:::V:::AD:::::::::::::
NP1988A         ::::::::MS:T:::V::::::::::L:::::::EE::V:::S::S::::::::::::::
rrnAC0365       :::::::::::::::V::::::::::L::::::::E::I::::::D::V:E::KD:::::
Hmu1299         :::::::::--------------------::E::SD::I:::::::S::::A::::::::

consensus       VDTPIPEDVAEMEVRATTPAAVPD-DIDLLFSSLPSDVGAEVEPAFLEAGYVVSSNSSND
#oth            212.1.1311423.53.2.231211.22.1..1...311321..21311.11....1..4
VNG1435         L:::V::SI::LP:QP:::::I::::TA::::A::::::::::::LC:::F:::::A::E
Hut1459         I:::::DHIG::T::::E::::::::::::::::::A::EA:::D:A::::::::::::F
HQ2908A         IN:::::NIGS:T:KS:::D:IS:::::::::::::::A:D:::::::::::::::::::
HVO_2487        :N::::D:::A:::GS:D::::::::::::::::::S:A:::::::::::::::::::::
Hbo2387         :N::::D:::::K:T::::E:::N::V:::::::::G:AT:I::E::HE:::::::::::
hla1528         ::::::D:::::::TE::::GIA:A:V:::::::::G:AS::::::::E:::::::::::
NP1988A         :::::::S::D:T:VE:D:D:::::::::::::::::I::D:::E:V::::::::::::G
rrnAC0365       :NS:::::::GL:::::D:DS:::::VG:I::::::S:::::::E:C::::T:::::::A
Hmu1299         I:A::::::::I::G::::ED:::::V::I::::::G:::::::E:C::::::::::::G

consensus       RMAPDVPLTIPEVNPDHLDLIEVQRDERGWDGALVKNPNCSTITMVPTLAALD-EFGLER
#oth            .224.1..21..1.12.121111..13.......2............2...1122.1124
VNG1435         :R:G::::VV::::A:::G::D::::A:::::::::::::::::::::::::T:::::D:
Hut1459         :TD::::::::::::::VE:LD::::Q:::::::L::::::::::::P:::::EA::V::
HQ2908A         ::SA:I::::::I::G::::::::::N:::::::::::::::::::::::::::Q::::T
HVO_2487        ::::::::::::I::E::::::::::::::::::::::::::::::::::::::Q:::::
Hbo2387         ::::::::::::I::G::::::::::::::::::::::::::::::::::::::Q::::S
hla1528         :::A::::::::I::G:::::::::::::::::::::::::::::::::::I:::::::S
NP1988A         ::DD:I::::::::A:::G:::::::::::::::I::::::::::::A:::::::::::N
rrnAC0365       ::DE::::I:::::A::V::L:::::::::::::L::::::::::::P:::::R::D:TD
Hmu1299         ::DE::::V:::::A::::VL:R::E::::::::L::::::::::::P:::::EA:::TD

consensus       VRVSTLQAVSGAGYSGVTSMEIIDNAIPHIGGEEEKMETESRKLLGEFDGAEVQLHEADV
#oth            13.2..........1.......1..21.1....25..12.......2.1.241522212.
VNG1435         :H:A::::::::::::::::::L::VV:::::::R:::::::::::::T:::::H:D:V:
Hut1459         :D::::::::::::::::::::::::::::::::T:::::::::::::::S::EWLD:::
HQ2908A         :S:::::::::::::::::::::::T::Y:::::P::QQ::::::::::::S:S:::M::
HVO_2487        :D:T::::::::::D::::::::::::::::::D::::::::::::S::::::A::G:E:
Hbo2387         :H::::::::::::::::::::::::::::::::N:::::::::::::::TD:S:::M::
hla1528         :::::::::::::::::::::::::::::::::::::::::::::::::::::H::G:::
NP1988A         IH:::::::::::::::::::::::V:::::::A::::::::::::S::::G:D::::::
rrnAC0365       ::::::::::::::::::::::::::::::::::Q:::S:::::::S::::::::N:M::
Hmu1299         ::::::::::::::D:::::::::::::::::::::::::::::::G:::TAIE::GM::

consensus       AASCNRIPTLDGHLENVFADTADDVSPADAAEAMRSYPG-ADLPSSPDQLIHVF--DEPD
#oth            2.....11.......1.111243133221242.223332131.1.1.22..41.112214
VNG1435         S:::::V:::::::::::VE:S:HPA:::V:A:FEDA:T:L::::A::P::ET:::TA:E
Hut1459         :::::::::::::::::W::LDG:::VEE:::::AA::S::::H:::GP::K::::::::
HQ2908A         :::::::::::::::::::E:TA:::AEE:ID::E:V::::::::::::::::::::D:S
HVO_2487        N::::::::::::::S::::L:::A::E:V:A:::E::::V::::A:E::::::::EDEF
Hbo2387         :::::::::::::::::::E::E::T:DE::::::E:S::V::H:A::::::::::ED:A
hla1528         :::::::::::::::::::EF:E:P::::LR:::::FE:A:A:::::::::K::GE:::E
NP1988A         S:::::V::::::::::W::L:A:PD:::VV::FE:::S:V::::::::::E::::::::
rrnAC0365       :::::::::::::::::W::::E:I:A:::EA::E:VT::I::::::EK::T::::E:::
Hmu1299         :::::::A:::::::::WV::E:::TV:::ED:L::AE::I::::::::::R::::::::

consensus       RPQPRLDRNRGDGMQIAAGGVQETDDGIQYNCLAHNTIRGAAGASVLNGELLVEEGYV
#oth            .....1..4422..2132..344.44.311.1.....2.......2......354.12
VNG1435         ::::::::M:::::A:::::I:T::T:::::::::::::::::::I::::::AR::W:
Hut1459         ::::::::::E:::::SV::I:::ET:::F:T:::::L:::::::I::::::::K:::
HQ2908A         ::::::::E::N::::S::::TV::A:LK::::::::::::::::L:::::::DA:W:
HVO_2487        ::::::::D:::::::S:::I:S::H:VK:::::::::::::::::::::::AQ::WI
Hbo2387         ::::::::E:::::::C:::LH::AN:LK::::::::::::::::L::::::::::W:
hla1528         ::::::::TYAG::G:V:::::A:NA:MK::::::::::::::::L::::::::::::
NP1988A         :::::M::ML::::A::T:::ES:A::::F:::::::M::::::::::::::L::::L
rrnAC0365       :::::::::VE:::GV:V::FR::T::V:F:::::::M::::::::::::::NKR::L
Hmu1299         :::::::::IE:::GV:V::::::T::L:F:::::::M::::::::::::::AAN::L