[F] (PurM) COG0150 Phosphoribosylaminoimidazole (AIR) synthetase 9 genomes BUD0211 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG0876 rrnAC0438 HVO_1557 Hbo3494 Hmu1113 Hut1126 hla2459 NP3940A HQ2665A

Pairwise sequence scores
Consensus score	2464	HQ2665A	VNG0876	HVO_1557	Hbo3494	hla2459	Hut1126	NP3940A	rrnAC0438	Hmu1113
1816	HQ2665A	2554	1479	1612	1780	1735	1639	1530	1535	1604
1802	VNG0876	1479	2474	1651	1692	1682	1581	1550	1565	1603
1993	HVO_1557	1612	1651	2420	1896	1792	1605	1756	1675	1753
2099	Hbo3494	1780	1692	1896	2511	2012	1699	1736	1720	1772
2071	hla2459	1735	1682	1792	2012	3037	1718	1739	1682	1814
1871	Hut1126	1639	1581	1605	1699	1718	2585	1677	1886	1831
1975	NP3940A	1530	1550	1756	1736	1739	1677	2437	1874	1865
1944	rrnAC0438	1535	1565	1675	1720	1682	1886	1874	2498	2079
2050	Hmu1113	1604	1603	1753	1772	1814	1831	1865	2079	2472

409 symbols
consensus       ------------------------------------------------------------
#oth            111111111111111111111111111111111111111111111111111112232334
HQ2665A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::MS
VNG0876         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::MT
HVO_1557        ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo3494         :::::::::::::::::::::::::::::::::::::::::::::::::::::MTDTDAG
hla2459         VGRLLRPLRRAHDRARVRRRTRLRRAVLSRASPAPAGPAVLALHPFAGNGALLLRGRPST
Hut1126         :::::::::::::::::::::::::::::::::::::::::::::::::::::::::MAE
NP3940A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
rrnAC0438       :::::::::::::::::::::::::::::::::::::::::::::::::::::::MTDSE
Hmu1113         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       -MTDDDD-------------DDDGLTYADAGVDIDASEAATAALIGAVGEFEGD--YAGL
#oth            5333264222233333223244111...22....22.....2..221123241.111...
HQ2665A         NPP::TAERNTDIKTNASEE:S:E::::A:::::E::::::::::D::::SA::::::::
VNG0876         AGENA:G::::::::::::::P::::::::::::AD::::::::VD:ASTGTD:TA::::
HVO_1557        :::N:--::::::::::::::S::M:::::::::E:::::::::VAQ::GGS::::::::
Hbo3494         EGPA:EA::::::::::::::::E::::::::::::::::::::V:::::S:::::::::
hla2459         H::EG:GGETGGGDEEPTIDG::E::::::::::::::::::::::::::G:::::::::
Hut1126         HEA::G::::GASSSDATDEP:EE::::AS:::::E:::::E::LD:A:::A::::F:::
NP3940A         :::E::S:::::::::::::EAE:::::ET::::E:::::::::L:::ED::::::::::
rrnAC0438       SEA::A::::::::::::::SEE:::::ET:::::::::::K:::::A:::K::::::::
Hmu1113         :::::S:::::::::::::::EE::::::S:::::::::::::::::A::::::::::::

consensus       VDIGDRYLALATDGVGTKLLVAEALDDYSTVGIDCIAMNVNDLVAAGVRPVAFVDYLAVD
#oth            2.1..1..1..........1..1.331...1........1...2.1.12.1.......11
HQ2665A         I:::::::::::::::::::::A:MNE:::I:::::::::::::::::::::::::::I:
VNG0876         ::L::Q::::::::::::::::::VG:::::::::::::::::L::::E:A:::::::::
HVO_1557        L:::::::G::::::::::::::::::::::::::::::A::::::::::::::::::::
Hbo3494         L::::::::::::::::::I:::::G:::::::::::::A::::::::::::::::::::
hla2459         L::::::::::::::::::::::::S::::::::::::::::::::::::::::::::::
Hut1126         :::::::::::::::::::::::::::::::::::::::::::::::IE:::::::::IE
NP3940A         ::::::::::::::::::::::::::::::I::::::::A:::I:T::T::::::::::E
rrnAC0438       :::::Q::::::::::::::::::V:::::I::::::::A:::I:T::E::::::::::E
Hmu1113         :::::Q::::::::::::::::::I:::::I::::::::::::::T::E::::::::::E

consensus       EPDERFAEQVGEGLAAGAERADIALVGGETAVMPDVIRGLDLAGTCAGLAPKDALFPGEA
#oth            3.12442222.4..45..24.222.2......1.1.13.1.1..111.1142222.313.
HQ2665A         D:::NLT::I:V::DT::DI:::T:I::::::L:E:VD:F:::::::::T:::GV:TET:
VNG0876         ::N::R:AEL:D::::::DA:GV:::::::::::::V::F:I:::A::V:TDAE::::R:
HVO_1557        A:::T::::::Q:::::::E:::E::::::::::E::N::::::::::::K:::I:::::
Hbo3494         ::::::::::::::SV:::::::E::::::::::E::K::::::::::::D:::::::::
hla2459         :::::::::::::::R:::L::ME::::::::::::::::::::::::::A:E:V:D:A:
Hut1126         A::STTTG:L::::QI:::L:::::I:::::::::::D:::I:::A:::::::G::A:::
NP3940A         T::DET::::::::SE:::::E:::L::::::::::::::::::A:V:::TE:E::D:::
rrnAC0438       T:::KTS:DI:A::RT::::::V::::::::::::::K:::I::::::::::::V:::::
Hmu1113         :::DEES::I:A::RE::K:::V::::::::::::::K:::I::::::::::::V:::::

consensus       EPGDALVGFPSSGIHSNGLTLAREAVTRDHEYTDPCPFDGYETIGEALLEPTRIYTDLLD
#oth            23..11..22.1...........2.3.2323.1213142334.2122..2...1.241.2
HQ2665A         N::::::::A:::::::::::::T:I::EY:::A:::::E:::L:A::::::::::::::
VNG0876         :A:::::::::A:::::::::::::A:::GG:DE:Y:YE::::V:D::::::::::H:::
HVO_1557        :E:::::::::::::::::::::K:A:A:GD:D:DWDG:D:D:V:::::::::L::Y:::
Hbo3494         :S:::::::R:::::::::::::T:T::::::::D:::E:::::::::::::::::N:::
hla2459         ::::::::WR:::::::::::::::A::E:A::::::::::::V::::::::::::::::
Hut1126         :::::I::W:::::::::::::::::::::D:D::F:PEPST::::E::A::::::::::
NP3940A         AA::Y:::L::::::::::::::::::QR:D::::F:Y:DDR::::V::::::::REV:G
rrnAC0438       :A:::I::W::::::::::::::::::Q:::::::F:PNPDT::A::::T:::::SEV:A
Hmu1113         :::::I::W::A:::::::::::::::AN:::::DY:R:PEQ::A::::T:::::::::G

consensus       PLRAHETHAAAHVTGGGWTNLTRMGEFRYVIDDPFDAQPVFEFVQSEGSVSDEEMHRTFN
#oth            221222122...1....11..3.1.531.113111222.1.11..43.4.1.2..12...
HQ2665A         :MH::DVRT:::I::::LR::E:L:SH::::::::ETP:I::::::A:N:::S::YQ:::
VNG0876         AF:E:GV:::::I::::::::D:::G:::EVS::LP:::::DY::DA:G:::A:::::::
HVO_1557        D:::A::N:::::::::::::E::::::::V::A::P::::::::ER:G:::::::T:::
Hbo3494         :M:E:GVN:::::::::::::E:::D:H::VE:A::PH::::::::::N:::::::::::
hla2459         :M:D:GVRG::::::::::::::L:AN:::V::A:EP:::::::::::::::::::::::
Hut1126         :::E:G::::::::::::R::::::PY::E:EE::::::I:::::TV:D:::A:::::::
NP3940A         ::H:A::::::::::::::::S::::Y::::E:::EP::::::::E::::D:::::::::
rrnAC0438       ::::S::::::::::::::::::::SY::E:T:::E:::::::::A::E:::::::::::
Hmu1113         :::DA:::::::::::::::::::::H::E:T:::::::I::::::::::::::::::::

consensus       MGTGFVAALPEDDAEALV-EATDGRVIGRVEDG----DGVSIRGLEL--
#oth            ......2133242.2521235312211.3.431211133.21.1.2.22
HQ2665A         ::::::C:MSPKN::M:A::::E:KI::Q:DT:::::E:::::::::::
VNG0876         ::::::V:::::A:A::A:SQ:::E:V:::A::::::::::::::S:::
HVO_1557        ::::::::V::EN::::::::::S:::::::A:::::::::::::D:::
Hbo3494         :::::::::AP::::::A:D::::::::H::::::::S:::::::D:::
hla2459         ::::::::VDP:A::S:A:AE::::::::::E:DDDEGS:A::::::::
Hut1126         :::::::TFDPA::MNV:E:TA:::I::::V:SD:::E:::::::D:Q:
NP3940A         ::::::::::A:::::V:E:LS:A:I::::::::::::A:E::::::::
rrnAC0438       ::::::::V::A::AEI:ADSE:A::::E:A::D:::EA:A::N:::TE
Hmu1113         ::::::::M::SA::TV::::::::I::E:T::E:::GC:AV:::::TG