[C] (Ppa) COG0221 Inorganic pyrophosphatase 9 genomes BUD0601 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG0259 rrnAC3323 HVO_0729 Hbo0805 Hmu0799 Hut1904 hla0236 NP5192A HQ1231A

Pairwise sequence scores
Consensus score	1403	HQ1231A	VNG0259	Hbo0805	Hut1904	NP5192A	Hmu0799	rrnAC3323	hla0236	HVO_0729
1184	HQ1231A	1395	1188	1241	1101	1138	1170	1152	1147	1177
1219	VNG0259	1188	1394	1236	1102	1139	1177	1149	1165	1177
1246	Hbo0805	1241	1236	1404	1134	1155	1198	1188	1190	1244
1233	Hut1904	1101	1102	1134	1389	1201	1248	1225	1197	1217
1304	NP5192A	1138	1139	1155	1201	1423	1282	1267	1266	1281
1338	Hmu0799	1170	1177	1198	1248	1282	1411	1316	1283	1303
1328	rrnAC3323	1152	1149	1188	1225	1267	1316	1403	1295	1290
1334	hla0236	1147	1165	1190	1197	1266	1283	1295	1403	1309
1350	HVO_0729	1177	1177	1244	1217	1281	1303	1290	1309	1401

180 symbols
consensus       --MTNLWEDLETGPNAPDEIYAVVECLKGERNKYEYDKDIPGVVLDRVLHSNVHYPSDYG
#oth            1213..1111.1..11.111...1............1..2.1.1............2...
HQ1231A         :::S:::T::::::D:::VV:::I:::::::::::::::V::::::::::::::::::::
VNG0259         :::A::::::::::D:::V:::::::::::::::::::::::::::::::::::::::::
Hbo0805         :::::::::M::::D:::VV::::::::::::::::::::::::::::::::::::::::
Hut1904         :::V::F:A::A:::P:E:::::::::::::::::::::L::::::::::::::::::::
NP5192A         MAGA:::::::::::::E:::::::::::::::::::::::::M::::::::::::G:::
Hmu0799         :M:::::::::::::P:E:::::::::::::::::::::V::::::::::::::::::::
rrnAC3323       :::::::::::::::P:E::::::::::::::::::E:::::::::::::::::::::::
hla0236         :::V:::::::::::::::::::::::::::::::::::::S::::::::::::::Y:::
HVO_0729        :::V:::::M::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       FIPQSYYDDEDPFDVLVLVEDQTFPGCVIEARPVALMKMDDDGEQDDKVIAVPTEDPRYD
#oth            .2..11...2..1.11...........1.........3......1........4....1.
HQ1231A         :L::T:::::::::IM:::::::::::I:::::::::R::::::K::::::::D::::::
VNG0259         :::::::::G:::::::::::::::::::::::::::E:::::::::::::::E::::::
Hbo0805         :M::T:::::::::I::::::::::::::::::::::G::::::K:::::::::::::::
Hut1904         :::::H:::D::L:::::::::::::::::::::::::::::::::::::::::::::::
NP5192A         :::::::::::::::::::::::::::I:::::::::::::::::::::::::S::::::
Hmu0799         :::::::::::::::::::::::::::I:::::::::::::::::::::::::S::::::
rrnAC3323       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
hla0236         :::::::::::::::M::::::::::::::::::::::::::::::::::::::::::F:
HVO_0729        ::::T::::::::::::::::::::::::::::::::::::::::::::::::V::::::

consensus       HIEDLDDIPQQTLDEIDEFFETYKNLEAGKEVETLGWEDKQAAKDAIEHAQDLYDEQFA-
#oth            111.12.212.121..1...2......21.11111..1213..4...1.121..1.4141
HQ1231A         :V:::::LTD::TA::A::::::::::T::QT::::::SAD::T::::::ME::E::ID:
VNG0259         DV::V::LTD:QKA::A:::::::::::D::TAV:::G:A::::::::::::::::::::
Hbo0805         :VQ:V::LTD:QK:::A:::::::::::::::::::::GAD:::::::::M:::::N:::
Hut1904         :::::E:::S:Q:::::::::::::::E:::::::::::AA::R:::::SRE::E:KI:E
NP5192A         :::::E:::::::::::::::::::::E::::::Q::::::::F::::::::::E:H:G:
Hmu0799         :::::::::::Q::::::::A::::::::::::::::::::::Y:::::::E:::::I::
rrnAC3323       :::::::M::::::::::::S::::::E::::::::::::E::::::V:::E::::E:N:
hla0236         :::::S:L::::::::::::S::::::::::::::::::::::R::::::::::::E:Q:
HVO_0729        ::::::::::::::::::::A:::::::::::::::::::::::::::::M:::E:N:::