[L] (Exo) COG0258 5'-3' exonuclease (including N-terminal domain of PolI) 9 genomes BUD0614 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG1359 rrnAC0032 HVO_2873 Hbo2639 Hmu1081 Hut0169 hla1644 NP3784A HQ2418A

Pairwise sequence scores
Consensus score	2469	VNG1359	hla1644	HQ2418A	HVO_2873	Hbo2639	Hut0169	NP3784A	Hmu1081	rrnAC0032
1912	VNG1359	2525	1595	1580	1770	1694	1766	1652	1714	1733
1917	hla1644	1595	2448	1697	1824	1746	1714	1666	1690	1646
1916	HQ2418A	1580	1697	2441	1743	1907	1680	1654	1687	1700
2072	HVO_2873	1770	1824	1743	2464	1930	1843	1863	1765	1850
2028	Hbo2639	1694	1746	1907	1930	2452	1744	1764	1735	1788
2026	Hut0169	1766	1714	1680	1843	1744	2465	1798	1819	1861
2020	NP3784A	1652	1666	1654	1863	1764	1798	2491	1770	1870
2010	Hmu1081	1714	1690	1687	1765	1735	1819	1770	2466	1871
2054	rrnAC0032	1733	1646	1700	1850	1788	1861	1870	1871	2469

329 symbols
consensus       MGNADLRSLAALEDVSFDDLEGSVVAVDAHNWLYRYLTTTVKFTSDEAYTTSDGEEVANL
#oth            ....1..31.212332.222311.1.........1......21.4334...33.2.....
VNG1359         :::::::Q:::I:ETP:A::::::::::::::::K::::::QW:GADV::::::T:::::
hla1644         :::::::D:::IR:I::AEI::::::::::::::::::::::W:A::T:::T::V:::::
HQ2418A         ::::A::Q:::::S:A:::IS:::I:::::::::::::::::::::A::::ES:V:::::
HVO_2873        :::::::T::::SE::::EVS:::::::::::::::::::::W::S:T::::E:::::::
Hbo2639         ::::::::::S:SE::::::A:G:::::::::::::::::::::G::V:::TE:::::::
Hut0169         :::::::DI:VI::::::V:::::::::::::::::::::::W:N:DI:::A::T:::::
NP3784A         :::::::T:::I:PKP::E:G:::::::::::::::::::::::RS:::::A::::::::
Hmu1081         ::::::::::S::::P:EE:SD:::::::::::::::::::R:::::K::::::T:::::
rrnAC0032       ::::::::::::S:::::::G::::::::::::::::::::::::ESK::::N:::::::

consensus       IGVVQGLPKFFEHDLTPVFVFDGGVTELKDDEVAKRREQREKAEEQLEAARERG--DAVE
#oth            1.2...1.....1121..1.1..1.111.12.134..32.142134342.2.1111.352
VNG1359         V:A::::::::::G::::::W:::::::::::I:D::::::RY::::DD:::A:::::A:
hla1644         ::I::::::::::::I::M::::A:::::A::::D:::K::Q:::RRV::K:::::::::
HQ2418A         ::::::::::::::::::::::::::::::E::QE::VA::E:V:LQA::E::::::ELA
HVO_2873        V:I:::I::::::::::::::::::::M:::::::::::::::::R::E:::A:::::::
Hbo2639         ::I:::::::::::::::::::::::::::A::SE::A:::::::LKKE:E::::::DM:
Hut0169         V:::::::::::A:V::::::::A::D::::::QR::::::QY:D:::D:::A::::::R
NP3784A         ::::::::::::::V::::::::::SD::A:::E:::D:::RY:A:::::K::DET::A:
Hmu1081         :::::::::::::::::::::::::::::::::EQ:::A::AR::K:::::::::::SKA
rrnAC0032       ::::::::::::::M::::::::A::D::::::E::::::Q:Y:SE::::::A::::STR

consensus       AARLEARTQRLTDTIHETTRELLALLDVPVVEAPAEGEAQAAHMARRGD-VDYVGSEDYD
#oth            2121111.....21.32.1.21151..1.311......1.113.1332211.11.11...
VNG1359         ::::D:::::::P:::::::::FD:::I:Q::::::::::::Y:T:TD:A:::A::D:::
hla1644         :::::::::::::::Q:::::::R:::::I::::::::::C::::AT:T:::HA::::::
HQ2418A         :S::::::::::E:::::::G::NR::::II:::::::::::E::I::::::::::::::
HVO_2873        :::M::::::::E::QD:S::::S:::::::::::::::::SY:::K:::A:::::::::
Hbo2639         :::::::::::::V::::S:G::ER:::::I::::::::::SY::KQ:::::::::::::
Hut0169         V::::S:::::::V:L:::::::::::::T:D:::::::::::::::::::::::T::::
NP3784A         I:A::S:::::::::V::::::::R:::::::::::::::::::::::::A:::::::::
Hmu1081         V:::DSQ::::::::LT::::V:R:::::::D::::::::::::::QNV::::::T::::
rrnAC0032       V:K:DS:::::::::VD:::D::E:::::I:D::::::G::SV::::::::::::T::::

consensus       ALLFGAPYTLRQLTSKGDPELMDFEATLDDHDLTWEQLVDAAILCGTDFNEGISGIGPKT
#oth            2..1.1.5.1.11..2.2..1..131..452232311.1.212.1.....2.23.3..2.
VNG1359         C::L:S:V:::::::S:H::::::D:::AE::::::::::VG::::::::P::D:F::T:
hla1644         T::::::T:::::::::::::::LA:::::LGFDRQG:::::M:::::::::VR::::::
HQ2418A         T::::::::V:::::::::::::LQT::KNQN::R:::::V:::::::::D:::::::A:
HVO_2873        T::::::::::::::::N:::::LD::::K::I:Y:::::I:M::::::::::T::::::
Hbo2639         T::L:::::::::::::::::::L::::S:L:V:Q:::I:I::::::::::::::V::::
Hut0169         :::::::F:::::::S::::::::::::AE:::S::::::V:L:::::::D:VR:Y::::
NP3784A         :::L:::::::G:::N::::C:::::::ST:::S::G:::::::M:::::::L::V::::
Hmu1081         :::L:::L:::::::S::::::::Q::::H:GI:::::::::::M:::::P::D:V::::
rrnAC0032       :::::::M::::I:::::::::::A:::EH::::::::::::::M:::::::::::::::

consensus       AVKAVREHGDLWGVLAARDEHIEHADRIRELFLDPAVTDDYDIDTDINPDLDAAREFVTD
#oth            .224251....23112111351411111.21.21.21.3113433323.1421..31.22
VNG1359         :LD:IG::::::D::::EG::VA:G::::::::N:D:::::V::P:VS:AI::::A::::
hla1644         :::::::::::::::D::GVE:PN:EA:::::M::PA:-:V:V::AV:::V:::::Y:V:
HQ2418A         :IS:IND:::::S::D::::F:Q::::V:S:::::P::NE:TLH:T::::M::::SY:V:
HVO_2873        :::V:T::::::S::E::GAS:PN:::V::F::::P::::::Y::::D::VA:::::::E
Hbo2639         :L:E:K::::::T::E:::DY::N:::V::::R::P:::::EF:::LS:::::::AY:SE
Hut0169         ::::::::::::::SENE:VYV:N::::::::::::::EE:T:E:S:D:::A::::::::
NP3784A         :::LIH:::::RS::::::DD:P:::::::::::::::::::Y::::D::FER::::::E
Hmu1081         :I:L:K:::::::A:D:::A:V::G:::::::::::::::::L:LAV:::::::::Y::G
rrnAC0032       :::DLH:::::YT:::::G:::D::::::D::::::A::::E:PDS:E::I::::T::::

consensus       EWEVDADEVARGFERIEESVVQTGLDRWT
#oth            3.2.2221.2.1..1.24133....13.2
VNG1359         :::::::A::::::::DAAAA::::::::
hla1644         ::G:A::::E::::::A::Q:::::::::
HQ2418A         D:::P::::E:::::::T::::::::E:I
HVO_2873        T::::PE::R::::::::::T::::::::
Hbo2639         ::::P::::::::::::D:L::::::Q::
Hut0169         Q:A:::E::::::::::S:::::::ED::
NP3784A         T:G:P::::E::::::::::I::::::::
Hmu1081         :::::EG::::A::H::A::::::::D:A
rrnAC0032       Q:::::::::::::::DD::::::::::A