[H] (LipA) COG0320 Lipoate synthase 7 genomes BUD1181 8 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG2216 rrnAC2959 HVO_2957 Hbo1577 Hbo3928 Hmu3189 - hla1158 NP0562A -

Pairwise sequence scores
Consensus score	2418	NP0562A	Hbo3928	hla1158	VNG2216	HVO_2957	Hbo1577	rrnAC2959	Hmu3189
1990	NP0562A	2398	1841	1885	1850	1887	1818	1913	1850
2108	Hbo3928	1841	3161	1988	1936	2028	1958	1950	1941
2058	hla1158	1885	1988	2439	1909	2002	1921	1917	1931
2117	VNG2216	1850	1936	1909	2401	2000	1999	1972	1948
2229	HVO_2957	1887	2028	2002	2000	2421	2073	2018	1948
2151	Hbo1577	1818	1958	1921	1999	2073	2327	1950	1936
2137	rrnAC2959	1913	1950	1917	1972	2018	1950	2422	2054
2090	Hmu3189	1850	1941	1931	1948	1948	1936	2054	2398

405 symbols
consensus       ------------------------------------------------------------
#oth            111111111111111111111111111111111111111111111111111111111111
NP0562A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo3928         MFLIRDCRTHQQIKRTSVNGRKNEIGRNTLEAVNSQTMPQFPTLKNQRKQLINWWRISER
hla1158         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
VNG2216         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HVO_2957        ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo1577         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
rrnAC2959       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hmu3189         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       ----------------------------------MSRRRKPDWLKMRPPSGRRFTDIKQT
#oth            1111111111111111111111111111111112334311121122.....2...1..22
NP0562A         :::::::::::::::::::::::::::::::::MS::::::E::RT:::::::::E::E:
Hbo3928         IRGILIESTVYVRIALRSLQPHPQFYHGTTEAFG:TS::::::::::::::::::E:::S
hla1158         :::::::::::::::::::::::::::::::::MQRG::::::::S:::::S:::E::ER
VNG2216         ::::::::::::::::::::::::::::::::::::S::::E:::::::::E::::::E:
HVO_2957        :::::::::::::::::::::::::::::::::::RT:::::::::::::::::::::S:
Hbo1577         ::::::::::::::::::::::::::::::::::-----------:::::::::::::::
rrnAC2959       :::::::::::::::::::::::::::::::::::::S:::::::::::::E::::::::
Hmu3189         :::::::::::::::::::::::::::::::::::::A:::::::S:::::::::E:::S

consensus       LRDRDLHTVCEEANCPNLGECWSGRDGPGTATFMLMGDRCSRGCNFCDVETGGMEPLDPD
#oth            ..121.1......1...1.1....2..........1.............4....31..1.
NP0562A         ::::::N::::::::::::D:::::::::::::::L:::::::::::::A::::D:::::
Hbo3928         :::H::::::::::::::::::::H:::::::::::::::::::::::::::::S:::::
hla1158         ::E::::::::::::::M::::::::::::::::::::::::::::::::::::KS::S:
VNG2216         :::N:::::::::S:::M:::::::::::::::::::::::::::::::K::::::::::
HVO_2957        ::::N:N::::::::::::::::::::::::::::::::::::::::::T::::::::S:
Hbo1577         :::::::::::::::::M:::::::::::::::::::::::::::::::Q::::::::::
rrnAC2959       ::::N:N:::::::::::::::::::::::::::::::::::::::::::::::D:::::
Hmu3189         ::E::::::::::::::M::::::E:::::::::::::::::::::::::::::::::::

consensus       EPANVADAVAEIGLDYVVLTSVDRDDLPDQGAGHFAETIREIKRRDPSILVEVLIPDFQG
#oth            ..31..21.21................2.1.13...2...1.12..111...3.1...1.
NP0562A         ::::::E::::::::::::::::::::D:G::::::::::::::::T:V:::A:::::::
Hbo3928         ::S::::::S:::::::::::::::::A:G:SA:::::::::::::::::::::T:::::
hla1158         ::E::::::::::::::::::::::::A:G:SE:::::::::Q::::E::::T:::::::
VNG2216         ::::::ES:::::::::::::::::::D::::::::R::::::E::::::::::::::::
HVO_2957        :::::::::T::::::::::::::::::::::A::::::::::::::EV:::::::::::
Hbo1577         ::::::A:::::::::::::::::::::::::S:::Q::::::Q::::::::::::::::
rrnAC2959       ::QQ::::::::::::::::::::::::::::S:::::::A::E::::::::C:::::::
Hmu3189         ::E:::::::D:::::::::::::::::::::::::::::A::E::::::::C:::::R:

consensus       DPDAVRKIIDAGPDVIAHNIETVERLQWPVRDRRAGYEQSLSVLRQVNRESDIYTKTSLM
#oth            2332132.1..2...2...1...4.1.1.1.....2.1.1.2..42252111212...2.
NP0562A         :T:::DR::::D:::V:::V:::::::::::::::::::::D::::IAAADGC:A:::::
Hbo3928         S::::QR:L::::::F:::::::N:::::::::::D:D:T:D::Q:A:D:::V:::::I:
hla1158         ::E:IDR::::::::::::V:::::::::::::::D:::::A::DR:G:::::H::::::
VNG2216         EKSL:Q:::::::::::::::::A:R:V::::::::::::::::EY:T::::::::::I:
HVO_2957        ::EH:::::::::::::::::::::::::I::::::::::::::Q::TD::::H::::V:
Hbo1577         :EE::::::::K:::::::::::::::::::::::N::::::::E::K::::::::::I:
rrnAC2959       E::L:::::::D:::::::::::D::::::::::::::::::::::::::::C:S:::::
Hmu3189         EERL:EQ::::::::::::V:::Q::::::::::::::::::::G::D::::::::::::

consensus       LGVGEYAHEVYQTLSDLREAGVDVVTLGQYLQPSRSHLDVFEYVHPDAFETWRRVAEDEF
#oth            ..1..12..1.1..1..1111..1..1........1..1.21..1.13.11.231..5.2
NP0562A         :::::::::::R::G::S:V:::I::F:::::::::::E:::::T::T:DV:K::::T::
Hbo3928         ::L:::H::::::::::::V:::I:::::::::::::::::::::::V:::::DI::E:M
hla1158         ::::::D::::R::G::S:V::::::F::::::::::::::::::::V:::::A:::R::
VNG2216         ::::::D:::::::G:::::::::::::::::::::::::AD::::QK::::Q::::S::
HVO_2957        ::L::H::::::::::::::D::I::F::::::::::::::::::::::::::::::::L
Hbo1577         ::L:::D::I::::::::::D::::::::::::::T:::::::::::::::::Q:::::L
rrnAC2959       ::::::::::::::::::Q:::::::F:::::::::::E:S::::::::D::QQ:::A::
Hmu3189         :::::::::I:::::::::V::::::::::::::::::E:S::::::::D:::::::E:L

consensus       GFLYCASGPMVRSSYKAGELFVDALLREGKSVEEARRAARAAAG-
#oth            2.1...........11......112212.41334..341133434
NP0562A         ::::::::::::::F:::::::E::E:D:LDI:A::A::ERQ--:
Hbo3928         E:::::::::::::::::::::::::::::::AQ::KR::VNGD:
hla1158         D:::::::::::::::::::::E::::::R:P:D:::H::::G:D
VNG2216         ::::::::::::::::::::::::V:::::::Q::::N::R::SE
HVO_2957        :::::::::::::::::::::::::::::S::::::Q:::::::Q
Hbo1577         ::::::::::::::::::::::::IV:D:::::Q:::E::T:::S
rrnAC2959       D::::::::::::::R::::::ESV::::R:AD:::AEV::ND-:
Hmu3189         ::A::::::::::::R::::::E:V:-A:NDPAI:::R:::EE-: