[C] (NuoB) COG0377 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases 9 genomes BUD0132 10 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG0636 pNG7189 rrnAC1448 HVO_0979 Hbo0462 Hmu1949 Hut1395 hla2599 NP2294A HQ1638A

Pairwise sequence scores
Consensus score	1797	pNG7189	hla2599	Hut1395	VNG0636	NP2294A	HQ1638A	HVO_0979	Hbo0462	rrnAC1448	Hmu1949
1501	pNG7189	1769	1417	1393	1445	1436	1419	1484	1476	1510	1502
1647	hla2599	1417	1805	1507	1568	1539	1557	1622	1620	1551	1559
1568	Hut1395	1393	1507	1792	1581	1549	1499	1553	1552	1518	1547
1653	VNG0636	1445	1568	1581	1838	1589	1530	1627	1590	1597	1611
1652	NP2294A	1436	1539	1549	1589	1775	1549	1608	1605	1615	1610
1639	HQ1638A	1419	1557	1499	1530	1549	1814	1671	1645	1531	1573
1737	HVO_0979	1484	1622	1553	1627	1608	1671	1810	1734	1618	1638
1721	Hbo0462	1476	1620	1552	1590	1605	1645	1734	1843	1624	1628
1667	rrnAC1448	1510	1551	1518	1597	1615	1531	1618	1624	1788	1674
1675	Hmu1949	1502	1559	1547	1611	1610	1573	1638	1628	1674	1781

236 symbols
consensus       MSSDQ--PFVTDDT---TSTRDARM-GDGADDRFNSKLREAFGSSPFILTKFDKFMNWVR
#oth            ..123555644143223131222122151322....2...11..1........3.1..2.
pNG7189         ::::R::RN:D:AQ:::--SD:RICP:RR:N:::::T:::VL:::::::::::T:L::::
hla2599         :::::::::I::ESQVV:E:::S::T:Q:--:::::R::::::::::::::::::L::C:
Hut1395         ::QNTQQSES:GTK:::-:::E:::::E:V::::::R::::L::T::::::::Q::::A:
VNG0636         :::::PRDSI::TSDPL::::::::::::V::::::R:::::::T:::::::::::::::
NP2294A         :::EK::--LH:T::::-::QQ:::::::V::::::::::::::T:::::::::::::::
HQ1638A         :::E:DNA::::::QVQ:D:::::I:-S:T:E:::::::::::::::::::::Q::::::
HVO_0979        :::E::K:::::::QVQ:E:::::::-A::::::::::::::::::::::::::::::::
Hbo0462         :::::NQ:::::::QVQ:E::::::T:S:::N:::::::::::::::::::::N::::::
rrnAC1448       :::::TP:A:E:VS:::--:QE::::::::::::::T:::::::T:::::::::::::::
Hmu1949         ::::::::TPG:AQ:::-::QE::I::S::::::::::::::::T:::::::::::::::

consensus       GSSMFMLQFGIACCSIEMMHTYAVKHDLDRFGAGVPRASPRQADVIIVPGTIVSKFAPRM
#oth            .1...1........1...11.112.......21...........11..............
pNG7189         :::::V::::::::T::::G:L:T:::::::A::::::::::::L:::::::::::::::
hla2599         ::::::::::::::::::::::::::::::::S::::::::::::M::::::::::::::
Hut1395         ::::::::::::::::::::::S::::::::H:::::::::::::M::::::::::::::
VNG0636         ::::::::::::::::::::::S::::::::H:::::::::::::M::::::::::::::
NP2294A         :N::::::::::::::::I::::I::::::::::::::::::::::::::::::::::::
HQ1638A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HVO_0979        ::::::::::::::::::::::S::::::::A::::::::::::::::::::::::::::
Hbo0462         ::::::::::::::::::::::S::::::::A::::::::::::::::::::::::::::
rrnAC1448       ::::::::::::::::::I::::I::::::::S:::::::::::::::::::::::::::
Hmu1949         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       KRVYDQMPEPKFVVGMGSCTISGGPFQEGYNVIKGAEEVIPVDIHVPGCPPRPEALIYGV
#oth            ......1.....112..1.12...........1....1...1..11..........1..1
pNG7189         ::::::::::::::S::::::::::::::::::::::Q:::::::::::::::::::::I
hla2599         :::::::::::::::::::::::::::::::::::::::::I::::::::::::::V:::
Hut1395         ::::::V:::::TI::::::::::::::::::V::::::::I::QI::::::::::::::
VNG0636         ::::::::::::::N::N:ST:::::::::::V::::::::::::I::::::::::V:::
NP2294A         :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::I
HQ1638A         ::::::::::::::::::::V::::::::::::::::::::::::I::::::::::V::I
HVO_0979        :::::::::::::::::::::::::::::::::::::::::::::I:::::::::::::I
Hbo0462         ::::::::::::::::::::V:::::::::::::::::::::::::::::::::::::::
rrnAC1448       ::::::::::::::S:::::::::::::::::::::::::::::::::::::::::::::
Hmu1949         ::::::::::::::S:::::::::::::::::::::::::::::::::::::::::::::

consensus       AKLQERIANGESSPVTVKPYELEQFGDLERDELVDKLADEIDEEDLVMRYNWADSP
#oth            1...1.121..21..1......11.2..11..1132..3211112.....1121.1
pNG7189         ::::::::E:::::::::::::::::::::::::::::S::::D::::::D:S-::
hla2599         V:::::V::::AA::::::::::E:S:::::::::::::QVEDDE::::::F::::
Hut1395         :::::::::::::::V:::::::E:::::Q::I:E::::Q:::D::::::::::::
VNG0636         :::::::::::::::::::::::E::::::::I:::::AD::::S:::::::::::
NP2294A         :::::::R:::T:::::::::::E::::::::::QH:::Q::::::::::::::::
HQ1638A         :::::::S::::A:::::::::Q::D::SQ::I:SQ::E::::D::::::D::::S
HVO_0979        ::::::::::::::::::::::::::::::::I:::::E:::::::::::::::::
Hbo0462         ::::Q:::E::::::::::::::::::::Q:::I:H:::Q::::::::::::::::
rrnAC1448       ::::::::E::::::::::::::::::::Q::::::::S:::::::::::::N:::
Hmu1949         ::::::::::::A::::::::::::::::Q::::::::A:::::::::::::::::