[P] (-) COG0428 Predicted divalent heavy-metal cations transporter 9 genomes BUD0688 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG0938 rrnAC3110 HVO_1003 Hbo0439 Hmu2636 Hut1695 hla0394 NP4402A HQ2238A

Pairwise sequence scores
Consensus score	1952	NP4402A	VNG0938	HQ2238A	rrnAC3110	Hmu2636	hla0394	Hut1695	Hbo0439	HVO_1003
1257	NP4402A	1976	1150	1019	1111	1139	1137	1182	1179	1164
1364	VNG0938	1150	1971	1153	1222	1219	1166	1174	1179	1232
1418	HQ2238A	1019	1153	2395	1318	1334	1290	1293	1205	1233
1575	rrnAC3110	1111	1222	1318	1985	1594	1385	1363	1410	1393
1576	Hmu2636	1139	1219	1334	1594	1966	1387	1457	1423	1426
1636	hla0394	1137	1166	1290	1385	1387	1964	1499	1453	1480
1583	Hut1695	1182	1174	1293	1363	1457	1499	1958	1427	1480
1610	Hbo0439	1179	1179	1205	1410	1423	1453	1427	2076	1538
1618	HVO_1003	1164	1232	1233	1393	1426	1480	1480	1538	1963

340 symbols
consensus       MVALANLAFVFVAGLITALATGLGAIPFFFVDDISDRWNVALWGLASGIMVAASLFGLVR
#oth            144334231.23..24.1111.3.11...223221.123.2...3.1...12..2..124
NP4402A         -ML:EG:L::LA::IF::IVC:F:TL::::::E::::VT:::::::G:::LF:::::FIF
VNG0938         :SPSGE:L::VF:::L:D:::::::L::::::::D:::R:G::::::::::S::G:::F:
HQ2238A         ::V::H::L::::::A::::::::::::::I:EF::::::G:::V:::::::::::::IN
rrnAC3110       :::VE:VV:::::::L:::::::::::::L::EF::::::L:::::::::::::::::::
Hmu2636         :ALVE::VL::::::L:::::::::::::V:::F::::::::::V::::::S::::::::
hla0394         ::::DAF:::::::::::::::I::L::::F:S::::G::::::F:::::L::::::::D
Hut1695         :SL::::TL:::::F::::::::::L:::L:E::::Q:Y:::::::::::::::::::IF
Hbo0439         -M::D:F:::::::F::::::::::::::::Q::::::::::::I:::::LS::V::::L
HVO_1003        :DQF:A:T:::L:::V::I:::V::::::::S:V::::::::::V::::::S:::::::F

consensus       EGLA----------------YGTPIELGAGLLAGVALVVVAHRVI---------------
#oth            .1141111111111111222413352333.332.121.3223322111111111111111
NP4402A         :::R::::::::::::::::D::VF:V::::VV::VV::::D:I::::::::::::::::
VNG0938         :A:N::::::::::::::::::G:T:IA::A::::::::::EH:::::::::::::::::
HQ2238A         ::MQ:::::::::::::YASD:F:VLMLT:::T:::::EGSG::LSRIDINATGPDESGH
rrnAC3110       ::::::::::::::::::::::S:VL:VP:V::::G::A:::ELL:::::::::::::::
Hmu2636         ::::::::::::::::::::::S::L:VP::::::V::::G:::V:::::::::::::::
hla0394         ::::::::::::::::::::E:::G:I:I:M::::::::L::D:L:::::::::::::::
Hut1695         ::::::::::::::::::::E::A::IAI:MA:::V:::L::::L:::::::::::::::
Hbo0439         :A:GEYISVSLAGISVSPIPTR:FLL:::::I::IV::::::D:::::::::::::::::
HVO_1003        ::::::::::::::::::::N:::LQ::I:M:::::::L:::H:::::::::::::::::

consensus       -------------------------------------DDAEIEPKDYEEADFKKLLLILG
#oth            11111111111111111111111111111111111113242541352231.321.2..2.
NP4402A         :::::::::::::::::::::::::::::::::::::TGY:F::R:IPD:::R::V::V:
VNG0938         :::::::::::::::::::::::::::::::::::::::H:F::R:IAA::V:::A::A:
HQ2238A         GDDGYPRDEGNKQTDPAPDIGTDGGPEATPHIESQEH::NPL:AEVFADG:L:T::::::
rrnAC3110       :::::::::::::::::::::::::::::::::::::::FDQS::QF:Q:::T:::::::
Hmu2636         ::::::::::::::::::::::::::::::::::::::SYDHH:EAF::::::::V::::
hla0394         :::::::::::::::::::::::::::::::::::::M::::D:QE:::::::::V::::
Hut1695         ::::::::::::::::::::::::::::::::::::::G:::D:QE:A:::Y:::V::::
Hbo0439         ::::::::::::::::::::::::::::::::::::::G:DVH::R::::::R:::::::
HVO_1003        :::::::::::::::::::::::::::::::::::::EG::VN::Q::::::R:::::::

consensus       ILTVHSFPEGVAVGVSFADLGLEG-----GLQLFGFGVPLLAVFMTIAISIHNVPEGTAI
#oth            1..1......1.2..1..12.2211111235523.342.3..1.1.3....1.1...2.1
NP4402A         V:::::::::::L::A:::::I:::::::D:V:A:LAI:G::I:I:A::::Q:I:::L:V
VNG0938         V::::::::::::::::::M:ID::::::::SVL::SI:I:::::::::::::::::L:V
HQ2238A         ::::::::::::::::::EI:FD:::::::IGI::I:I::::::::V::::::I::::::
rrnAC3110       ::::::::::::::::::E::::AATPESAVGIV:VS:::::::::V::::::I::::::
Hmu2636         V:::::::::::::::::E:::A:A:::ETVTVL:L:L:V::::::V::::::::::V::
hla0394         V:::::::::I:::::::::::::::::::T:::::T:::::::::L:::::::::::::
Hut1695         ::::::::::::::::::E:::::A:::E:PI:::VT::I::::::::::::::::::::
Hbo0439         :::I::::::::I::A:::::::::::::::::::VV::::::::::::::::I:::V::
HVO_1003        ::::::::::::::::::::::D:::::::F:::::V:::::::::L::::::::::L::

consensus       SIPLRSMGVSNWKMVWWAVFSSLPQPIGAVIAFAFVRLAREFLPFGFGFAAGAMIYLVLT
#oth            1..11332343.2211211.1.1...1..12.12..25.231..2.1...2...11..12
NP4402A         A:::HTY:IA:::IFG::::::I::::::G::YV::TT::::::::::::S::::F:::H
VNG0938         ::::HEH:ARR:TL:GV:::T:I::::::G::YV::QI::AA::::Y:::G:::VF:::S
HQ2238A         A::M:A::L:K:R::GA:::::::::::::::::::TW:ES:::::::::::::::::V:
rrnAC3110       A:::::L:::E:::::::::::::::V:::::YY::T::KA:::::::::::::V:::::
Hmu2636         :::::TL:::E:::::::::::::::::::::::::::::::::::::::::::V:::V:
hla0394         ::::::::::K::::::S::::::::::::V::::::Y::::::Y:::::::::::::VS
Hut1695         A::::::D:GE:R:::::::::::::::::L::::::V::D:::Y:::::::::::::::
Hbo0439         :::::::::P::RL:::S:::::::::::::::Y::::::::::V::::::::::F::::
HVO_1003        :::::::N:::::L::::I::::::::::::::Y:::I::::::::::::::::VF::::

consensus       EFIPEALETGADLPGGGRRELAAGIAVGVAAMVPLAFV--
#oth            112..1115.54.144.232.43.343.114.2.232211
NP4402A         DIF::G:DH:S::::H:::::LV:::::::I:L:VMLLTE
VNG0938         ::::::R:V:GA::HN::::::T:::::::G:::ML::T:
HQ2238A         :::::::::::::EHS:Y:A::G:VIA:::V:I::LY:::
rrnAC3110       ::V:::::Y:DG:::::K:::LT::::::L::::::::::
Hmu2636         ::V:::::Y:R:::D:::K::VT:AVA::LL:::::::::
hla0394         :::::::::::::::::KPV::G::GL::LL::::N:I::
Hut1695         ::::::::::::::SR::P::T::VV::::I:::::LI::
Hbo0439         ::::::::R::E::R::::::C::::C::L:::::L::::
HVO_1003        ::::::::L:KR::R:::V::L::LTA:F:V::::::I::