[O] (ECM4) COG0435 Predicted glutathione S-transferase 9 genomes BUD0630 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG2281 rrnAC2356 HVO_0670 Hbo0863 Hmu0007 Hut0199 hla2664 NP5048A HQ1275A

Pairwise sequence scores
Consensus score	2639	VNG2281	HVO_0670	Hbo0863	HQ1275A	hla2664	NP5048A	Hmu0007	rrnAC2356	Hut0199
1878	VNG2281	2643	1611	1650	1582	1495	1574	1758	1695	1728
1943	HVO_0670	1611	2589	2032	1925	1527	1460	1717	1722	1697
1971	Hbo0863	1650	2032	2636	2092	1528	1554	1762	1783	1765
1977	HQ1275A	1582	1925	2092	2653	1499	1541	1725	1773	1689
1951	hla2664	1495	1527	1528	1499	2743	1730	1792	1859	1822
1997	NP5048A	1574	1460	1554	1541	1730	2539	1915	1900	1954
2251	Hmu0007	1758	1717	1762	1725	1792	1915	2660	2233	2258
2293	rrnAC2356	1695	1722	1783	1773	1859	1900	2233	3327	2257
2289	Hut0199	1728	1697	1765	1689	1822	1954	2258	2257	2623

437 symbols
consensus       ------------------------------------------------------------
#oth            111111111111111111111111111111111111111111111111111111111111
VNG2281         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HVO_0670        ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo0863         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HQ1275A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
hla2664         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP5048A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hmu0007         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
rrnAC2356       MSRYIEAGLSDIGTLGEYVAERPNKGFEPARRRAGVSHTTVSGPKLAVAVMAVSAVCCPC
Hut0199         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       ------------------------MNMLVDGEWRTDA-YETTNEDGEFERQTTSFRDRI-
#oth            111111111111111111111111133231.1.1.131233222..2.3.22.2..2211
VNG2281         :::::::::::::::::::::::::GRMI::D:::E:DMNEHSD::A:::D:::::HWV:
HVO_0670        ::::::::::::::::::::::::::::YE::::::K:FVAN:::::::::::D::NWV:
Hbo0863         ::::::::::::::::::::::::--::::::::::::::S:::::::N::E::::NW::
HQ1275A         :::::::::::::::::::::::::::::::::::::::Q:::D::::D::E:::::E::
hla2664         ::::::::::::::::::::::::::Q:::::::::T:::A:DG::S:Q:GE:T::NW:A
NP5048A         :::::::::::::::::::::::::HQFL::::V:E-:::A::::::::::::T::::V:
Hmu0007         :::::::::::::::::::::::::::::::::::::::Q::::::::::G:::::::::
rrnAC2356       GCQCVLVTPLSPRSFTLCAHIIDT::T:::::::::::::::::::A:D::D:T::::V:
Hut0199         ::::::::::::::::::::::::--:::::::::::::Q::::::A:::G:::::::::

consensus       --------EDDPDARFQPEAGRYHLYVSRACPWAHRTLLTRALLGLEDAISVSVVDPYRG
#oth            11111111541223222221....1.212.......2132.3.2....2.2112.1.3.3
VNG2281         ::::::::G::----VP:A:::::::::Y::::::::::V:::::::::::::::::V:Y
HVO_0670        ::::::::GE:--E::PV::::::::IC:::::::::AM::::K:::::::L:L:E:V:I
Hbo0863         ::::::::R::A::E:PA:S::::::I::::::::::AM::R:K:::::::L:::E:V:I
HQ1275A         ::::::::VS:A::E:PA:S::::V:I:::::::::VAM::R:C::::D::L:::E:E:Y
hla2664         GSDVPDHIDAE::D::::::::::::::Y::::::::::A:S::::::::D:::::::::
NP5048A         ::::::::--::E---EAT:::::::::Y:::::::::IA:R::::::V:::D::::::A
Hmu0007         :::::::::::::::::::::::::::CL::::::::::V:S:K::::::::DY:::F::
rrnAC2356       ::::::::::::::::::::::::::AC::::::::I:VA:K::::::::T:DY:::F::
Hut0199         :::::::::::::::::::::::::::C::::::::::V::::K::::::T:DY::::::

consensus       EDGWQFSPEK-GCTPDPVNGSDYLREVYTEADPEFTGRVTVPVLWDKQEETIVNNESREI
#oth            32..2.231141121.4131422..13.42..233.1.......1.2432.1.....2..
VNG2281         DQ::T:D:::P:::::H:F:GTH::D::::::::Y:::::::::Y:TDAD:::::::E::
HVO_0670        D:::E::ED-:--L:::LY:EEF::DI:LR::D:::::::::::::::R:::::::::::
Hbo0863         N:::E::A:-:--Y:::LY:E::::DI::R::D::::::::::::::ER:::::::::::
HQ1275A         ::::E::TD-:--Y:::LYDAE:::DI::R::::::::::::::::E:T:::::::::::
hla2664         :G::::T:::E:::::KLH:::::::L:I::::DA:C:::::::::TE:G:V::::::::
NP5048A         A:::::::::D:::::T:::F:::::A:VA:::NY:::::::::::TV:D::::::::::
Hmu0007         D:::::T:::A:::E:S:::::::::::QA::SGM::::::::::::RA::::::::E::
rrnAC2356       ::::::T:::A:::::T:::::::::::V::::DA:C::::::::::::::::::::E::
Hut0199         ::::::T:::D:::::T:::::::::::V::::DM::::::::::::::::::::::A::

consensus       MRMLDTAFDDLAENDVDLYP----EGYREEVDRIIDEIYEPINNGVYRAGFADSQAAYDE
#oth            1.2.322.233262112.4.11111123211.24224..1.1.....12...11.4..23
VNG2281         :::::V::::H:AR::::::::::::::D::::L:ED::D:::::::::::::::R:::N
HVO_0670        :::::E:::P:::R::::N:::::D::E:::::LV::::::V::::::::::TT:E::E:
Hbo0863         ::::::E::AH:KH::::W:::::::::::::ES::S::::::::::::::::::D::::
HQ1275A         ::::N:::E--GS:::E:W::::::::::::::V:::::D:::::::::::::T:E::NA
hla2664         L:I:S::::::G-::AS:L:TPDD:ATVAD::EV:T:::::V::::::::::T:::::::
NP5048A         L:N:T:V:A::G-:G:::S:::::::L:DDI:DAL:R:::::::::::T::::::::::D
Hmu0007         L:::::E::AV:TR::::::::::::::::I:::::::::::::::::T::::::::::D
rrnAC2356       L:::::E:::VSD::::::::::::::QD:::::::D:::::::::::S::::::S::::
Hut0199         ::::::E:::V::H:::::::::::::Q:DI:E::EA::::::::::K::::::::::::

consensus       AVEELFDALDHWDDVLEDQRYLAGDRLTEADIAMFTTLVRFDEVYHTHFMCNRKLIHEYD
#oth            .1311.2..121241.21..111..31....21112..2...2......1..213142.2
VNG2281         ::DD::E::A:Y::::AE:::::::V:::::V::::::Y::::::::::K::::R:SD::
HVO_0670        :::::::::::::E::D:::F::::VV::::::::A::I:::H::::::K::K:A:::::
Hbo0863         :IT:::::::::ES::::::FVV::V:::::::::V::I:::H::::::K:::RA::::P
HQ1275A         ::::V:::::::E:::D:::F::::K:::::L:::V::I:::H::::::K:::RA::::P
hla2664         :ID:::G:::R:N:H:A:::::V::S::::::C:::::::::Q:::::::::K:FV:Q:E
NP5048A         ::A:::::::Y:NS::::::::V:::::::::::Y::::::::::::::::::R::R:::
Hmu0007         ::D::::::::::A::A:::::::::::::::C::::::::::::::::::::R::EQ::
rrnAC2356       :::::::::::::T::::::F:::::::::::CL::::::::::::::::::H:::R:::
Hut0199         :::::::::::::S::::::::::::::::::::::::::::::::::::::H:::A:::

consensus       NLWPYLRDLYQLPGVAETVNMDHIKEHYYTTHPDVNPKRIVPAGPDPDFEAPHDRDRLPG
#oth            2..1.11112113.233.3322.132..131.2122.111225..3211424.1..2.22
VNG2281         :::::::E:C::::::D:LY:E:V:Q:::RS:GHL::::L::T::N:A:F::::::Q:::
HVO_0670        :::N:TKE::::::::K:::::::VR::FVS:G:I:::::YGV:::L::D:E:::::::A
Hbo0863         :::N:TKE:A::::::::I:I:::TR:::MS:G::::::L::V:::I::YDD:::::::A
HQ1275A         :::N:TKE::::::IKS:::I:::MR:::VS:D::::::L::T:::I::ST::N:::::A
hla2664         H::::::::::TE::::::::A:::::::::::::T:TG:IAR:::L:W::A::::::DD
NP5048A         T:::::::::TTL:FG::TR:::::::::::::::S::::I::::A::::::::::E:A:
Hmu0007         :::::::::::T:::S::::V::::::::::::::S:::::::::E:::D::::::E:::
rrnAC2356       ::::::::::::::::::::::::T::::::::::S::::::M::::::::V::::E:::
Hut0199         ::::::::V:TTD::::::DI::::::::::::::S::::::K::A::::::::::E:::

consensus       DLPAALAAD--------
#oth            22.46286333212211
VNG2281         GP::::NQ-::::::::
HVO_0670        ::::::T::D:::::::
Hbo0863         ::::V:RG:AAPANE::
HQ1275A         :::DT:QSETTAAVADD
hla2664         EA:TPN:::::::::::
NP5048A         EP:V-----::::::::
Hmu0007         EP:ES:LETAD::::::
rrnAC2356       :::ET:FPTA:::::::
Hut0199         GP::D:V--::::::::