[E] (-) COG0436 Aspartate/tyrosine/aromatic aminotransferase 9 genomes BUD0062 11 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG0502 rrnAC3495 rrnB0206 HVO_1604 Hbo3241 Hbo3544 Hmu1041 Hut0194 hla1865 NP1666A HQ2629A

Pairwise sequence scores
Consensus score	2820	hla1865	HQ2629A	HVO_1604	Hbo3241	VNG0502	NP1666A	Hut0194	rrnAC3495	Hmu1041	Hbo3544	rrnB0206
2346	hla1865	2838	2180	2302	2253	2128	2068	2113	2155	2188	1894	1852
2235	HQ2629A	2180	2821	2239	2318	2002	1968	2059	2077	2121	1865	1800
2362	HVO_1604	2302	2239	2831	2362	2122	2050	2132	2130	2186	1941	1848
2337	Hbo3241	2253	2318	2362	2819	2051	2011	2088	2124	2168	1889	1839
2335	VNG0502	2128	2002	2122	2051	2826	2077	2180	2217	2220	1951	1919
2376	NP1666A	2068	1968	2050	2011	2077	2818	2283	2322	2290	2026	1926
2435	Hut0194	2113	2059	2132	2088	2180	2283	2820	2377	2306	2060	1975
2467	rrnAC3495	2155	2077	2130	2124	2217	2322	2377	2836	2438	2060	1929
2495	Hmu1041	2188	2121	2186	2168	2220	2290	2306	2438	2957	2051	1957
2125	Hbo3544	1894	1865	1941	1889	1951	2026	2060	2060	2051	2809	2105
2057	rrnB0206	1852	1800	1848	1839	1919	1926	1975	1929	1957	2105	2810

388 symbols
consensus       MTEFSDRVEQVSISGIREVFEAAGEDAINLGLGQPDFPTPDHARQAAVEAIEAGKADAYT
#oth            .37114.11421.....2...1.11.1....1.....11.2.2.3..32.132.62.2..
hla1865         :PN::::::RI:::::::::::::D::::::::::::::::::::::ID:::::::::::
HQ2629A         :YS::::::S::::::::::::::::::::::::::::A:A:::D::::::Q::E:::::
HVO_1604        ::H::::::RI::::::K::::::::::::::::::::A:::::::::::::::E::G::
Hbo3241         :S:::::I:K:::::::::::::::::::::I:::::AA:E:::R::I:::KD:R:::::
VNG0502         ::::::::A::::::::A::::::::::::::::::::::::::::::D:::S:A::G::
NP1666A         ::D::::::R::::::::::::::D:::::::::::::::::V:E::I::::::DV::::
Hut0194         :PD::H:::::::::::::::::S::::::::::::::A:E:::E::::::R::D::G::
rrnAC3495       ::A::R::::::::::::::::::::::::::::::::::E:::E::::::Q:::V::::
Hmu1041         :::::R:::::::::::::::::::::::::::::::::::::::::::::Q::::::::
Hbo3544         :SKYAP:::KMD:::::::::G:S::D::::I::::::::E:I:D::LS:V:D:VV:S::
rrnB0206        :SQYAA:::EMD::::::::::::::::::::::::::::E:::E::MS::QD:MG:S::

consensus       SNKGTRELREAIAAKHARDNGIDVDPDNIIATAGGSEALHIAIEAHVD------------
#oth            2.1.353.111.221141.22543414311..1.1...1.212...14111111111111
hla1865         E:::::S::::::E::RT:Q:::L::S:V:::::::::::::L:::::::::::::::::
HQ2629A         E:::MMS:::::::::Q::QN:T:N::E:::::::::::::VM:::I:::::::::::::
HVO_1604        G:::LPS::::::E::R::Q:V:L:::DV::::::::::::::::::N::::::::::::
Hbo3241         E:::I:S:::::::::E::Q::ERH::D::::::::::::::M::::G::::::::::::
VNG0502         ::R::AA:VD::VE:::::Q:V::A:AGV:::::::::::L:M:::::::::::::::::
NP1666A         :::::::::::::::YD:::DFA:::E::V::S:::::::L:::::::::::::::::::
Hut0194         :::::L::::::::::::::DL::::G:V:::S:::::::::L:::::::::::::::::
rrnAC3495       :::::E::::::::::E:::DLE:::GD::::S:::::::::L:::::::::::::::::
Hmu1041         :::::::::::::D:::::::M::::E:V:::S:::::::::L:::::GPGHSPGSDRTQ
Hbo3544         G:::ILG:::G:SE:YE::S:LS:::::::::S:A::::::::::::R::::::::::::
rrnB0206        ::::IP::::::SDRY:T:::Q:IPAE:::::::A:::I:V::::::Q::::::::::::

consensus       ---AGDEVIIPDPGFVSYDALTHLAGGTPVPVPLRDDLTLDPAAVEEAITDDTAAFVVNS
#oth            111413..14.....11.11.24211.2.3212..1...22.121.32..21.32.1...
hla1865         ::::::::L:::::::::::::K:T::E:::::::::::I::::I:A::::::V::::::
HQ2629A         :::P::::LV::::::::::::R:::::::::::::::::::::I::R::A:::::::::
HVO_1604        :::E::::::::::::::::::K::::E::::::::::::::::::D:::E:::::::::
Hbo3241         :::S::::::::::::::::::K::D::::::::::::::::::::::::::::::I:::
VNG0502         :::P::::LF::::::::::::RM:::N::GL::::::::A:ET::DH::::::::::::
NP1666A         :::::E:::F:::::::::::::I:::E:N::S:::::::S::D::A:::::::M:::::
Hut0194         ::::DE:::Y::::::::E::::::::::R::E::::::::::D::A:::::::::::::
rrnAC3495       :::::Q:::F:::::::::::::::::::R:::::E:::MA:ET::::::::::::::::
Hmu1041         SDN::Q:::F:::::::::::::::::::K:::::::::::::T::::::::::::I:::
Hbo3544         :::N:G::::::::::A:EQ:AV::::::K::E::::::::::T::D:::E::DL:I:::
rrnB0206        :::P::::LC:::::LA:EQ:VL::::E:KR:E:::::::::::::N::::N:SL:I:::

consensus       PANPTGAVQSPADMREFARIADEHDVLCISDEVYEHIVFEGEHRSPAEFAETDNVVVVNA
#oth            .1......1235.211.....1111.3.11.....33..1.112..31.33311.12211
hla1865         :G::::::S:EE:V:::::::::::::::::::::YT::::::Y::M::T:::::::I:S
HQ2629A         :G::::::S:QT:I:::::::::Y::F::::::::YT::D::FH::LA::DR:::::::S
HVO_1604        :G::::::SP:D:IA::::::::::::::::::::YT:::::::::I::::::::::::S
Hbo3241         :G::::::SP:E:I:::::::::::::::::::::YT::D::F::::::::::::::::S
VNG0502         :::::::::::::::A::::::::::::::::::::::::::::::M:::D:::::::::
NP1666A         ::::::::::E::::::::::AD:::V:L::::::PF::D:V:::::A:D::G:::::::
Hut0194         :::::::::::::::::::::::::::::::::::::::::::::::::::S:::::I::
rrnAC3495       :::::::::::E::::::::::::::::::::::::Q::::::::::::S::G:::I:::
Hmu1041         :::::::::::D:::A::::::::::::L::::::::::::::::::::DDGG:::::::
Hbo3544         :::::::::TES:::::::::::Y::V:LL::::::::::::::::M:::T:::::Q:::
rrnB0206        ::::::::::KR::A:::::::::E:I:L::::::K:::D:::H::::::NS:R:IQAS:

consensus       ASKLYSMTGWRLGWVTGSSERIERMLRVHQYVQACASAPAQYAAEAALSGPQDPVEEMTA
#oth            1..31..........41243.21..1.1...3....1..1.1......3.112315..23
hla1865         ::::F::::::::::Y::E::V:::::::::A::::::::::::::::R:DHGV:D::::
HQ2629A         :::::::::::::::L::TS:V:::::::::T::::A::S:F::::::T::::VIT:::D
HVO_1604        ::::F::::::::::Y::TR:V:::::::::::::::::::F:::::::::::RI::::E
Hbo3241         :::::::::::::::H:::R:::::V:A:::::::::::::F::::::T:::GI:D:::D
VNG0502         C::T:::::::::::AA:ER:A::::::::::::::::::::::::::::::GV:D::V:
NP1666A         :::A:::::::::::::T::::D::::::::A::::::::::::::::::::E:::::RS
Hut0194         :::A::::::::::::::D::::::::::::G:::::::::::::::::::::R:G::VD
rrnAC3495       C::A:::::::::::::ATD:::::::::::A::::::::::::::::T:::E::A::RE
Hmu1041         C::S:::::::::::::A:D:::::::::::A:::::::::F:::::::::::V::::R:
Hbo3544         C::S::::::::::::A:DD::::::::::::::::::::::::::::K:::E:::::VS
rrnB0206        C::T:::::::::::AA:A::::::::::::::::::::S::::::::T:::E::R::VS

consensus       AFEERRDVLLDGLEDIGLDVPTPKGAFYAMPEVPDGWVDECIDRGVVVVPGEAFGEHGAG
#oth            2.34..12211.1421.142.3.4....2..5..1.134122111.11...31..36.6.
hla1865         S::R:::L::::FDE::I:C:::Q:::::::R::E:F::::L::::::::::::::::R:
HQ2629A         S::R:::LIV:::T::::E::::R::::C::K::::F:M::LE:::II:::D:::AN:S:
HVO_1604        T:R::::LVVE:::::::T::S:G::::V:::::E:F:::::::::II::::::::::H:
Hbo3241         S:QR:::IVV::::::::T:::::::::::::::::F::::LE:::I::::::::AN:D:
VNG0502         :::A::::::::::AM:::::::G:::::::T:::::I::VV:::::::::S:::D::::
NP1666A         :::T:::::V:::::M::S::::::::::::::::::T::V::::::::::::::DA:::
Hut0194         ::::::N::::::::M::QT::::::::::::::E:::E:V::::::::::A:::DG:E:
rrnAC3495       ::K::::::::::NEM:::C:::::::::::K::::::::V::::::::::D::::::::
Hmu1041         :::Q::::::::::::::EC:::E:::::::K::::F:::::E::::::::::::AQ:::
Hbo3544         :::T:::::::::D::::ET:R:E:::::::S::E::AS:VL:N::I::::DV:::R:::
rrnB0206        ::::::N::::::A:::::T:V:::::::::H:::::TQKML:ND:I::::::::PS:K:

consensus       YARISYATDEETLKEALDVMAEATAAVR
#oth            3..1..112323.31.121.65125135
hla1865         H:::::::::SE:R:::::::D:YE:AK
HQ2629A         :::L:::::::S:R::::I:QQ:YT::S
HVO_1604        :::L:::::T:S:R::IEI:G::YD::V
Hbo3241         :::L::::::AS:H::::I::::YD::V
VNG0502         T::::::::MA::RD:I:::RA:::::Q
NP1666A         H::::::V:V::::D::E::G:::::L:
Hut0194         :::::::::M:Q::::I:::SA::::::
rrnAC3495       :::::::::M:::E::I:I::D::::L:
Hmu1041         ::::::PV:V:::::::SI:D::L:::Q
Hbo3544         ::::::::NV:::::::E::KSV:RSF-
rrnB0206        Q:::::::STAE:::::E::RTV:NSL-