[M] (WcaA) COG0463 Glycosyltransferases involved in cell wall biogenesis 9 genomes BUD0106 10 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG1053 rrnAC0419 HVO_1517 Hbo0036 Hmu1371 Hut1224 hla2607 NP3366A NP4658A HQ2694A

Pairwise sequence scores
Consensus score	2320	VNG1053	hla2607	NP3366A	NP4658A	HQ2694A	HVO_1517	Hbo0036	Hut1224	rrnAC0419	Hmu1371
1561	VNG1053	2264	1274	1365	1364	1219	1358	1279	1372	1388	1398
1563	hla2607	1274	2318	1332	1351	1414	1451	1381	1362	1459	1346
1828	NP3366A	1365	1332	2342	2284	1359	1408	1402	1470	1542	1546
1838	NP4658A	1364	1351	2284	2337	1367	1410	1411	1486	1543	1535
1677	HQ2694A	1219	1414	1359	1367	2985	1560	1581	1404	1419	1425
1738	HVO_1517	1358	1451	1408	1410	1560	2284	1701	1468	1545	1529
1742	Hbo0036	1279	1381	1402	1411	1581	1701	2617	1483	1468	1521
1720	Hut1224	1372	1362	1470	1486	1404	1468	1483	2351	1552	1626
1792	rrnAC0419	1388	1459	1542	1543	1419	1545	1468	1552	2603	1766
1822	Hmu1371	1398	1346	1546	1535	1425	1529	1521	1626	1766	2541

405 symbols
consensus       --MADRDDVCVLLPTYNEAETIGDVVDGFREEGFENVLVIDGGSTDGTREIAAEHGARVV
#oth            12253322.12.3..41.211124.1432554.2331..1..2.3.2.334.232..2.1
VNG1053         :MSEEYEE::A:V::R:::A::A::I::LF:V:VGH:::V::N:A:D:AAV::::::E::
hla2607         :::SEY:::::::::MD:V::VAR::EA::NA:LDG::::::::::::Q:A:R:A:::::
NP3366A         MR:P::T::::::::L::S:::::::G::YDH:::H:::V::D::::::A::R::::::I
NP4658A         MR:P::T::::::::LD::::::::IE::H:::::H:::V::D::::::A::R::::::I
HQ2694A         ::::SF:::T::V::::::::V:Q:::D:Q:A::DDI:::::D:::::QRV::N::::::
HVO_1517        :::PTP:A::I:T:::::::::A::ISDY:D:::A:::::::::::::::L:EDA::H::
Hbo0036         ::-M:Y::::I:I::::::::::G::SDYHS:::::I:::::::D:E:VD::EDR:::::
Hut1224         :::HT:::::::I::::::AA::::I:::QA::L::::::::::R:D:Q:::::::::::
rrnAC0419       ::::::::::I::::F::::::ES::S::::Q::D:I:::::::::::QDR:ESA:::::
Hmu1371         ::::::::::::V::::::A::::::AS:VGQ:::H::::::::D:::::L:::A:::::

consensus       EQS----GSGKGQAVREAVE-HIDAPYVLMLDGDGTYRPDDADRMLEPLFAGRAEHVIGD
#oth            4..1111.3.....1..124331222..112.1.2.152521341.2..43.513..1.1
VNG1053         Q:::::::D::::::::G:S:L:E:A:::L::::::NP:AQ:S:L:D::V::E::::V::
hla2607         ::::::::R::::::::::RD:::::::V:A:A:A::DAG:V:A::D::LS:E:V::::N
NP3366A         T::::::::::::::::G:::Q::Q:::::A::::::::E:::K::T:::::::::::::
NP4658A         T::::::::::::::::G:::Q::Q:::::A::::::::E:::K::T:::::::::::::
HQ2694A         T:::::::T:::::::::::RY::RT::::::::A::HT:::EG::::::D:S:A::V::
HVO_1517        V:::::::::::::::::::D::Q:::::::::::::EAT::TK::D::TE:Y-D:::::
Hbo0036         M:::::::::::::I:::::Y::E::::::::::A::CAK:::T:::::DE:Y-::::::
Hut1224         ::::::::::::::::::F::Y::::::::V::::::::A:::AL::::LS:D:D::::N
rrnAC0419       :::::::::::::::::::TR::EQ:::::A:::E:::::E:::L::::LS:Q:D::::N
Hmu1371         :::GTGR:::::::::::LNR:VEQ:::::::::A:::::E:::L:::::D::::::V:N

consensus       RFADMRPGAMTRLNQVGNRIINRAFATIHGRDLRDILSGYRAFTRESFRRMTLTADGFGI
#oth            .1..124...131.22..211.33.451..4235.1......1.33.25336.113....
VNG1053         :T::::::::ST:::I:::L:::::HR:::E:YG::::::::::A:::D::F:S:E::::
hla2607         :::::::::::Q::RI:::L::LS:RA:::EQY:::::::::::::::::LH::::::::
NP3366A         :::::EA:::::::A::::L:::L:::::::::Q::::::::::TQ::E:SK:S::::::
NP4658A         :::::EA:::::::A::::L:::L:::::::::Q::::::::::TQ::E:SQ:S::::::
HQ2694A         ::::L:E:::::F:::::S::::G:RAV::DQI::V:::::::::A:::E::::::::::
HVO_1517        ::::::::::::::R:::::::::::F:::Q:F:::::::::::::::LD::::S:::::
Hbo0036         :::::HD:::::F::L::::V:::::::::H:FE:::::::::::D::G:::::::::::
Hut1224         :::::ES:::::::R::::L::::::G::::NFV::::::::M::D:IE:FD::SA::::
rrnAC0419       :::::::::::K::::::::::S::E:::::::T:::::::::::Q::Q:SS:::S::::
Hmu1371         :::::EA:::::::::::G:::T::SV::::::T::::::::::L::V:QFD::::::::

consensus       ETEMAVECVKRNISTAVVPITYRARPDGSETNLRPIRDGGRIFLTLYRLAKTNNPLFYFG
#oth            ...11...21332413...11.33..3212...2.32..13.2.1.124.111..1....
VNG1053         ::::::::SRH::T:R:::T:::::::D:::::H::S::A::I::::S::::S:::::::
hla2607         ::::::::::NRQ:V::::::::E::G::A:::H::::::V:::E:::K:::::::::::
NP3366A         :::L:::::R:GV:::::::R:E:::G::::::H:LK:::::L:::::::RM:::I::::
NP4658A         :::L:::::R:GV:::::::R:E:::G::::::H:LK:::::L:::::::RM:::I::::
HQ2694A         ::::::::AR:D:P::::::::YP::S::D:::::V::::I:::E:F:Q:::::::::::
HVO_1517        ::::::::A::G:K:T:::T::YP:::::D:::D::::::I:::E:::R:::::::::::
Hbo0036         ::::S::::::::E:T:::::::P::S::D::::::::::I:::E:::R:::::::::::
Hut1224         :::LS:::::H::T:E::::R:ES::EDT::::::F:::AV:L:::::M:::::::::::
rrnAC0419       ::::::::::H:::::::::::QP:::E:D:::::F:::AT:I::::QM:::::::::::
Hmu1371         ::::::::::QGV::T::::::Q::::D:::::D:FS::AV:I:::::M:::::::::::

consensus       SVGAASTAVGVALAAYVAYEWLTVGVSHEVIALVAAAGILFGVQLLMFGVLSDLIVSLHR
#oth            .21542345.433241.3221324321..11.22244332111...2..2.1.2123211
VNG1053         :I::GFGTL:::::G::::D::LH:::::::::::GVSV::::::::::L::::::T:::
hla2607         :L::I::SA:ALMTG::L:D:IVN:IP::I::IG:VGAATL:I:::I::F:A:M:L::::
NP3366A         ::A:VG::G::::G:F:G:RY::A::::::L::L::FLV:LS:::::::::::I:::I::
NP4658A         ::A:VG::G::::G:F:G:RY::A::::::L::L::FLV:LS:::::::::::I:::I::
HQ2694A         ::::L::LT:LGV:V::IV::I::R:P::IL:V:::::V::::::::::::A:::Y:::S
HVO_1517        :::F::::T:LG::L::::::VVRSI::::::V:SM:::::::::::::::::::L::::
Hbo0036         :::GL:::I:IGI:L:::I::V::NT::::L:V::::A:::::::::::::::::L::::
Hut1224         :::T::LL::AL:GV:::V::F:RNI::::::::::V::I::::::V::::::M::K:::
rrnAC0419       :::LG::V::FL:G:::::D:VVNSI::::::V:GSFA::L:I::::::::::ML:AVN:
Hmu1371         :::V::AL:::V::I::::::FV:::::::::::::S:L:::I::::::::::M::A:N:

consensus       EQTRRL---------------------------------------------------DDI
#oth            114412111111111111111111111111111111111111111111111111111234
VNG1053         :::::I:::::::::::::::::::::::::::::::::::::::::::::::::::ERL
hla2607         ::VA:Y:::::::::::::::::::::::::::::::::::::::::::::::::::ERA
NP3366A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP4658A         ::S:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HQ2694A         :TMS:IGSVVEMDRTEQTVGGISRERDIDTDRKPDAHGSTIQPSHTDANDTLGSTTSS:V
HVO_1517        ::MK:I:::::::::::::::::::::::::::::::::::::::::::::::::::EEL
Hbo0036         DTL:KI::::::::::::::::::::::::::::::::::::::::::::::::::::EE
Hut1224         ::MH::::::::::::::::::::::::::::::::::::::::::::::::::::::QV
rrnAC0419       :::::::::::::::::::::::::::::::::::::::::::::::::::::::::E::
Hmu1371         :::::::::::::::::::::::::::::::::::::::::::::::::::::::::SE:

consensus       ADQLADQ-D------------------------------------
#oth            665566555534434433424343234433343343333323213
VNG1053         NK-----:-::::::::::::::::::::::::::::::::::::
hla2607         V:DGS:R:-::::::::::::::::::::::::::::::::::::
NP3366A         ::::EE:N:E:::::::::::::::::::::::::::::::::::
NP4658A         ::::EE:N:E:::::::::::::::::::::::::::::::::::
HQ2694A         SEED:TNKKATIPTELDKTQHEDSVVTKEDIDTEDGSTQTHGSDS
HVO_1517        E------:-::::::::::::::::::::::::::::::::::::
Hbo0036         TGTN:::TPDSGSNSNSGSTRPRGVRQDGGDEAETTDRSASNPDD
Hut1224         L:ADRKTE:GSRD::::::::::::::::::::::::::::::::
rrnAC0419       :V::THESHSQPADVFDDQQVSGAEGIEDSDTETEPAVSPHQSDE
Hmu1371         :R:VGNESTA::ADAVGDGTEPSAEGESDGERASSTSRP::::::