[C] (AceF) COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes 7 genomes BUD1182 8 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG2219 rrnAC2955 rrnB0198 HVO_2960 Hbo1574 Hmu3185 - hla0383 NP0556A -

Pairwise sequence scores
Consensus score	3750	rrnB0198	rrnAC2955	Hmu3185	HVO_2960	Hbo1574	NP0556A	VNG2219	hla0383
2245	rrnB0198	4009	1731	1627	2046	2082	2012	1922	1858
2705	rrnAC2955	1731	3971	2442	2121	2118	2145	1999	1901
2421	Hmu3185	1627	2442	3976	1920	1800	1989	1869	1915
2782	HVO_2960	2046	2121	1920	3839	2723	2256	2136	2135
2761	Hbo1574	2082	2118	1800	2723	3721	2261	2154	2095
2731	NP0556A	2012	2145	1989	2256	2261	3821	2130	2142
2572	VNG2219	1922	1999	1869	2136	2154	2130	3526	2297
2513	hla0383	1858	1901	1915	2135	2095	2142	2297	4004

616 symbols
consensus       -------------------------------MAREFELPDVGEGVAEGELVTWHVEPGDT
#oth            1111111111111111111111111111112344..3...1...11.1.212.2.41.13
rrnB0198        MPPCRSIHWRITTCHRRSVSKTASAKQSISN:V:::::::::::::::::LR:R:::::A
rrnAC2955       :::::::::::::::::::::::::::::::-MF::N:::L::::::::VL::R:S:::A
Hmu3185         :::::::::::::::::::::::::::::::-MF::::::L::::::::ILA:::::::R
HVO_2960        ::::::::::::::::::::::::::::::MALK::K::::::::::::::::::A:::E
Hbo1574         ::::::::::::::::::::::::::::::MAIE::K::::::::::::::::::T::::
NP0556A         :::::::::::::::::::::::::::::::::H::::::::::LT:A:I:R:L::::E:
VNG2219         ::::::::::::::::::::::::::::::::::::T::::::::::::::R:L:DE:::
hla0383         ::::::::::::::::::::::::::::::MPVK::K::::::::::::::::L:A:::R

consensus       VTEDQPVAEVETDKALVDVPSPVDGTVQELHAEEGEMVPVGDVIITFAV--DGE-DDAAA
#oth            .2...11........3.1..1122.1.4..3312.12.31.3131214222222343242
rrnB0198        :S:::::::::::::V:::::::::V:E::R:A::::::::::::V:R::::::::GPK:
rrnAC2955       :::::VL::::::::A:::::::::V:::::::V::::QT:E:L::I:EEG:A:TA::::
Hmu3185         :E:::VL::::::::A:::::::A:V:R:::Y:P:D::ET:A:VVSI:-::---:T:E:D
HVO_2960        :::::VL:::::::::::::::F::::K::L:::::V:::::::::IQE::::D::EE::
Hbo1574         :E:::V::::::::::::::::YN:::K::L::::::::::::::::E:::E::G:EEV:
NP0556A         :::::::::::::::V:E::A::N:::A::R:::::::S::T:::::D:::::D:S::TD
VNG2219         :::::::::::::::Q:E::A::::::::::WA::DV:::::LFV::D:::::::AS:T:
hla0383         :E:::::::::::::::E:::RY::::E::FV:::DI::::::::S:R:GE:::DVE:GG

consensus       DETDE---------EADEAASEAAET--------DE-ADAEPSTADG-RVFAPPSVRRLA
#oth            423231111111115325334543322211232333635543544411111.2.12.2..
rrnB0198        T::AP:::::::::AD:TT:GSGQQ:EVGATAQPA:ETQS::AITQRVQ:P:::::::::
rrnAC2955       SD:::AESAGADTE:::S::::::AA::::::::::QSG:ST::::::::::S:::::::
Hmu3185         ::::D::::::::::T::E:ATT:V:::::::::::S::S:::ATG::::::::N:::::
HVO_2960        EAA:A:::::::::D:EA:G::S::G:::::::::DG:SDDE:GSG::::::::::::::
Hbo1574         A:AEP::::::::::T::VSE:::::::::::::--:--G:TE:SS::::::S::::Q::
NP0556A         ::GEP:::::::::-::K:TTDE:A::::::EDD:STT::A:TG::::::::A::T::::
VNG2219         :DG:::::::::::SG:::::ATS:A::::::::--:--------S:::T:::::::T::
hla0383         :DSA::::::::::TGAD:TEPEP::DIGAETDAESD:ET::D:PP:::T:::::A::::

consensus       RELGVDIAAVDGSGPSGRITEGDVRAAAEDADD-AAAADDGPRSV---------D--GDD
#oth            ..1..1132.311111..1113..112234443144343443553454311113122425
rrnB0198        :::::::SS:AD:-S::::::P::::Y:SPESS:TQER-------:::::::::-::SSQ
rrnAC2955       ::K::::::::::::G::V:::::E::TAS::E::T:S::S:T::VSKA::::S:D:::S
Hmu3185         :::::E:T:::::::::::::S:::::G:::AS::DD:EVESAVSRVDD::::G::::SG
HVO_2960        ::::::LD::::::::::V:::::::::D:DG::EDDEPS:::T::::::::::-::QTN
Hbo1574         ::::::::S:S:T:::::V::S:::E:::SD:E:S::S:::::E:SFS::::::-:::::
NP0556A         :::::::::::::::G::V::A::::::DAT:TVESG:::A:P:GDDAD::::T:DTD::
VNG2219         ::::::LDS:E:::::::::D::::::::GGE::TTEP-------:::::::::-::ATE
hla0383         ::::::::V::::::G:::G:A::::H::GGG::H:G::A:DSGSDKAPAPTPT:VGSS:

consensus       AKSAVRRVDEGDSAAGS---SAAPS---AAQEAADRERTLAAPATRKLARELGVDIDAVP
#oth            53213531243453543111544444334461413.1311.2.1..43.513111113..
rrnB0198        QTT:AEQRTQQAAP:Q::::VSPAQT::--R:VV:::T:V:V:K::HI:A:E:I:L:T::
rrnAC2955       PTA::SQ::A::TDD:TAVK::VK:VSGDG::::S:DQ:::T:::::A::::D:N:::::
Hmu3185         V::::::::D::E:DDE:::PVVN:AVA:VDSD:E:D:S::T:::::::SD:::::::::
HVO_2960        G:::TAKR:::T::SA:::::S::T:::---:S::::Q::::::::A::K:E::::::::
Hbo1574         :V:KSGD:GN:EVTT:A:::-----::::SV:::G::K::::::::RV:E:K::::NN::
NP0556A         VR::::::::EADDG:::::D:T:DEKPT:A:::::D::::::::::::D:S:::L::::
VNG2219         :T::TE::::D:T::SA:::-----:::GS::P:G::K::::::::GV::::::::ND::
hla0383         R::::HKRGDDG::ES::::AD:::A:AG:P:S:G::T:::T:::::V:::::::::D::

consensus       TDEQRDGEAFVTAEAVQAYAEAQQAAQAADAAAVAAEAGAG--AA-A-----------E-
#oth            13131..111.2412.231.2234322432341345344246332334322122211134
rrnB0198        ::::K:::P:::L::::E::::::Q::QT:RD::VER:A:D::--:-:::::::::::-:
rrnAC2955       ::QT:::QPY:DEA::RT:::::::::::::E::S::G::AGT::E:GGAGAETT:::AV
Hmu3185         :::S::::PY:DEA::R:F:ASADETERER::GSTGR::EPST:DG:SG::::::::::A
HVO_2960        AT:M:::::::SP::::E::Q::RE::::::E::S:::D::TAT:E:TVDAASEPAPP:A
Hbo1574         AS:::::Q:::S::::HE:::::::::::::Q:L:E:E:::EAE:AEAA::::::::::T
NP0556A         :::T::::::::P:Q::Q:::::TE:::::T::::DTTADTA:--:-:::::::::::-:
VNG2219         AV:::::::::::::::::::GG::::GEAGG:ATR:FV::::--:-:::::::::::-:
hla0383         :::T::::::::G:I:R:::::LESGASPA:D::DTS:PEPKS:DAS:::::::::::LS

consensus       APGAGERREPYRGVRRTIGEQMARSKYTAPHVTHHDEVDVTGLVEARERLKPRAEERDVR
#oth            333522413..2.1.22..42.32.1112..11.1.312134..23124.433..12133
rrnB0198        E:ARP:S:K::K:I:Q:::AA:TS::::::::::Q::::::A::D::ST:RRE::AQ:I:
rrnAC2955       ET:D::::::::::::S::::::::RREV::A::::Q:V:S:::::::::A:L::::::T
Hmu3185         :SAE:Q:::::Q:::::::QR::E:RREI::A::::RAV:A:::D:H:::E:L::::G:D
HVO_2960        G:::::-:V::K:::KA::D::Q::::::::::::::::::E:::L::Q:::V::::GS:
Hbo1574         G:V:::-:V:::::::A::D::E::::::::::::::::::E:::L::E:::L:::Q:T:
NP0556A         ----:DE:I::::I::::::R::E::R:V::A:::::::::R:::I:D::SD:::A::TK
VNG2219         ----::TT:::::I:::::::::E::::::::::::TAVIDS:::T:SK::A:::AE::K
hla0383         :::SADETI::::::::::K::E:::::::::S:::TAE:D:::A:::E::R::::QG:K

consensus       LTYMPFVMKAVVAALKEHPVLNSQLDEENEEIVLRDDYNIGVAAATDAGLMVPVVEDVDR
#oth            ...1.112.122.1.323.52.33.1222...12234212.1.2...3..2....331.4
rrnB0198        ::::::::::CA:::Q:N:QV:VS:::A:::::EKQY::::::T:::D::L:::::N::A
rrnAC2955       :::T:::V:C:A:::DK:::::TA::T::::::Y::AH:::::::::H::V::::N:::G
Hmu3185         :::T:LLL:C:A:::R:::I:::E::A:A::::YH:RVDL:::::::H::V:::::R::E
HVO_2960        ::::::::::::::::GF:Y::::::::::::::::E:::::::::::::L::::H:A::
Hbo1574         :::::::::::I:::::F:FM:::::::::::::::E::::::T:::V:::::::D:A:G
NP0556A         :::::::L:::::G:Q::::::A::::DA::::::S:::V:::T:::::::::::D::::
VNG2219         :::::::::::::::::F:::::E:R:DD:::A:KQ:::::::V::::::::::::H::Q
hla0383         ::::::::::I::G:::Y:S:::E:R:DD:::::KG:::L:I:V::::::::::::N::E

consensus       KGLLELAREMNDLVEKARERKIAPEEMQGGTFTITNFGAIGGEYATPIINYPETAILGLG
#oth            .112221512111242..2.213121.3....111.2.21....12....3.13...12.
rrnB0198        :::::V:S:T:EKTQ:::::SLS::::R::::::S:I:G:::::G:::::Q::S:::A::
rrnAC2955       :::V:::G:V::::GR::::D:ERS::::::::V::::V::::::S::::V:::::::I:
Hmu3185         ::::AI:::V::::AR::D:DL:R:::::::::V:::::::::::D::::A:Q:::::T:
HVO_2960        ::M::::D:::EK:::::N::::::::R::::::::V:G::::::::::::::V:::A::
Hbo1574         ::::D:S:D::EK:::::::::::::::::::::::I:G::::::::::::::V:::A::
NP0556A         ::::AI:D::R:::S:::::S::::::::::::V:::::V:::::::::::::A::::::
VNG2219         :SM::IST:::::::Q::::S:::AD:D::::::::::::::::::::::::::::::::
hla0383         :::F:::E:VR::ASR:::::LT:A::K::::S:::::::::::::::::::::::::::

consensus       AIKERPRVVDG---------------------EVVARPTLPLSLSIDHRVIDGADAARFT
#oth            11221.11212211111111111111111222212126211...11...12...31.3.2
rrnB0198        E::KK::::EAD:::::::::::::::::GEETIEP:HIMT::::F::::L::::::Q::
rrnAC2955       :L::::VAE:::::::::::::::::::::::::::K:::::::A::::::::::::::V
Hmu3185         :L::::VAE::ETRAQRGSPNGERGAQRPASG:::::A::::::A::::::::::::::V
HVO_2960        ::::K::::::::::::::::::::::::::::::P:NV:T::::F::::V:::QG::::
Hbo1574         ::::K:::::::::::::::::::::::::::DI:P:KV:T::::F:::IV:::VG::::
NP0556A         E::RK:::::D::::::::::::::::::::::I:P:DV:T:::::::::::::E::S:V
VNG2219         ::D:::VAE:::::::::::::::::::::::D:R:AQ::::::::::::::::E::Q::
hla0383         ::E:::V:R:::::::::::::::::::::::::::A:::::::::::::::::V::E:A

consensus       NTVKEYLEDPELLLLE
#oth            .32322.53.51.111
rrnB0198        :SIQK::QN:N:::::
rrnAC2955       ::L::::S::TR::::
Hmu3185         ::L::::AE:S:::::
HVO_2960        :R:::L::::K::V::
Hbo1574         :K:::::MN:K:::::
NP0556A         :::SA:::::::::::
VNG2219         :R:M:::T::::::::
hla0383         :::M:H::H:L:::TQ