[F] (GuaA) COG0518 GMP synthase - Glutamine amidotransferase domain 9 genomes BUD0038 13 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG2501 rrnAC2924 rrnB0283 HVO_0208 Hbo1336 Hbo2886 Hmu2746 Hut0272 hla2583 NP0794A NP6256A HQ2947A HQ3668A

Pairwise sequence scores
Consensus score	1812	Hut0272	NP6256A	NP0794A	VNG2501	HQ3668A	HVO_0208	rrnAC2924	Hmu2746	hla2583	Hbo1336	HQ2947A	rrnB0283	Hbo2886
1149	Hut0272	1837	1300	862	885	894	967	1024	943	895	956	645	708	742
1135	NP6256A	1300	1898	834	854	928	932	1046	1000	866	979	595	714	710
1115	NP0794A	862	834	1835	888	848	939	1010	992	890	979	662	719	832
1170	VNG2501	885	854	888	1766	982	1056	937	879	1033	977	656	784	765
1151	HQ3668A	894	928	848	982	1899	1023	1000	934	1002	1159	701	710	753
1344	HVO_0208	967	932	939	1056	1023	1828	1080	1040	1030	1160	643	782	805
1326	rrnAC2924	1024	1046	1010	937	1000	1080	1850	1482	1029	1110	619	745	740
1263	Hmu2746	943	1000	992	879	934	1040	1482	1844	1012	1102	644	713	767
1185	hla2583	895	866	890	1033	1002	1030	1029	1012	1846	1173	663	631	699
1308	Hbo1336	956	979	979	977	1159	1160	1110	1102	1173	1812	669	772	814
778	HQ2947A	645	595	662	656	701	643	619	644	663	669	1808	869	844
972	rrnB0283	708	714	719	784	710	782	745	713	631	772	869	1837	1063
979	Hbo2886	742	710	832	765	753	805	740	767	699	814	844	1063	2013

271 symbols
consensus       ----MMRPRIALLNASHGDAPTRRNFRRELDADLVEFDVTDGELPD------HFAFDGVV
#oth            1221345332.221.124567251.13.21..324413345334.51232325461.151
Hut0272         :::::D:::L:::::A:EA:D:::::E:::::::DV:H:PA::::E::::::SLHY::F:
NP6256A         :::::DQ:SL:::::A:KAEE:KE::H:::::::ET:HCPT::F::::::::D:QY::F:
NP0794A         ::::-::::::::D:::N:PT:P:::::::::TVER:S:V:::F:S::::::TRR:::L:
VNG2501         :::::D::::::V::A:EPGE:A:::::::::E::::HAKG:RV:G:::::::TE:::::
HQ3668A         MAMGID:::L:::::::N:EH:::::::::::T:::Y:::AN:R:A::::::E:D:::I:
HVO_0208        :::::T:::L:F:D:::::SS:S:::::::::::::::::::R:::::::::::DY::::
rrnAC2924       ::::-::::::::::A:DGDDN::::::::::::::Y:::ER::::::::::T:::::CL
Hmu2746         ::::-:SL:::::::A:DG:LN::::::::::::::Y:::ER::::::::::T:::::CL
hla2583         :::::T:L:F:::::A:DG:N::::::::V:::::::SAS::H::::::::::TE:::::
Hbo1336         MKQGHGNL:F:::D:::::SN:::::::::::::A:::A:E::::S::::::::D:::::
HQ2947A         :::::SDLD:::CD::I::T:AE::::::V::S:TA:KLSVD:Q:PWPTADGEW:Y:AA:
rrnB0283        ::::-:NQT::IVD::V:ET:AE::LT:S:::ETTVYK:S::H::P:VPAGGDWRY::::
Hbo2886         ::::-:GV:::::D::V:NT:AE:::::V:::EVTT:KLSE:Q::P:PVTSRAWVY::::

consensus       VTGSRASVYWDEPWIRDLTEWVRDAAEAGVPALGVCFGHQLLADALGGRVEDMGEYELGY
#oth            21..331..1245.178273234425342326..1.2...22.5331.5.54.322.1..
Hut0272         ::::S::::::KE::GE:KT::G::VR::L::::::::::::::VM::S:KG::::::::
NP6256A         :::::::::::RE::GQ:KT::G::::::L:G::::::::::::V::::::G::::::::
NP0794A         :S:::::::::::::TATR::::N:VAD:LS:::I:W:::::::::::T::P::::::::
VNG2501         ::::KS:::::::::EA:CDY:E:VHA::::V::::::::V::E::::T::::SGF::::
HQ3668A         I::::S:::::RD::QP:IDYTAAVDDRNI:I::::Y:::V::A::::H::S:D::::::
HVO_0208        IS::SS::::::::::N:VS::A::D:R:::L::::::::VV:A::::T:::::AF::::
rrnAC2924       ::::::::::::::::::ES::DA:IDRDIAF:::::::::::H::::T::P:D:::I::
Hmu2746         L:::::::::E::::A:::S:::::V:RD:AF:::::::::::H::::E::P:D:::I::
hla2583         :::::S::::::E::PS:VDY:AE::D::L:V::::Y:::V::E::D:::AG:DGF:I::
Hbo1336         ::::::::::::K::PP:A:Y:A::::HDM:I::::Y::::::T::::H:Q::::::I::
HQ2947A         I:::QTA::DH:T:MET:A:LL::LH:LDI:L::::W:::FI:QTF::C:SA:D::::::
rrnB0283        IS::QT:::D:HG::H:::S::::VHR:D::T::I:W:::F::QS:::::V::::H::::
Hbo2886         IS::QI:::D:ND::HGA:::F:R:QA::::T::::W:::FI:Q:V::::V::H::::::

consensus       RTVER---DGDDPLFAGIDETFTVFTTHSDRVTELPPGATLLAENDYGIHAFRKGHAFGV
#oth            231521115453511214333211.31.1.4.323.33255215.331211.26365321
Hut0272         :P:NQ:::::SN::L::::::M:::MS:::H::DA:::S:VF:K:E:::QG:Q::R::::
NP6256A         ::I:Q:::::KNR:LED::::L::::S:::H:R:K:::::VF:R:E:::QG:::HNI:A:
NP0794A         :::SH:::-:GAG::D:VP:E:::::::::A::::::::E:I:T::::V:G::H:NVY:L
VNG2501         ::::::::VA:::::E:LP:SM:A::::G:V:::::AA:::::::::::::::V:QSV::
HQ3668A         :E:TQ:::TQS:T::ED:P:::::::S::::::::::ETIK::::::::::::R:::W::
HVO_0208        NEI::TRP:DGNDIL:::G:R:::::S:G:::::::S::D:::::EF:V::::RN:::::
rrnAC2924       ::::H:::::ENE:L::V::S:::::::::::A:V:::::TF::::::::G:::ENV:S:
Hmu2746         ::::H:::::TSE:LD:V::R:::::::::::V::::::EQF:A::::::G:QTEDV:S:
hla2583         NE:RH:::RS::E::::V::E:::::::G:A:VD:::N:S:IG:::H:V::::D::CW::
Hbo1336         :E:SQ:::TAE:E::E::::::::::::::A:A:::E::E:I:::E::V::::::::W::
HQ2947A         QQI:::::YDSS::::DFPAE:IA:E::::E:VR:::N::E::G:SRSCQ::SL:T:Y::
rrnB0283        :::H::::R:E:::::DMSPS::A:Q::::::A:::A::VE::R:Q:::Q:::L:TRY::
Hbo2886         ::IT::::V::S:::E:VPRR::A:E::::::A::::::VT::R::F:VQ:::V:GSY::

consensus       QFHPEYDRETAEEVTRGK-D--LPDERIDAVLDGITPENYAAACEAKRLFDNFTAYVRRH
#oth            .1.....42.1361353.133614343235.33422543243134314211..2752557
Hut0272         :::::::MD:::MI:::::SEQVSPAL:E::::::HA::::R:::::A:::::LTF::ET
NP6256A         :::::::M:::RMI:K:::SGD:SPQQ::::::::HST::E::::::Q:::::LS:::DI
NP0794A         :S:::::P::::S:V::::::H::ET::ER:CEE:::AA:ER:QP:::A::::LQV:E:N
VNG2501         :::::::T::::RIATE:::::VSEA:R::::A:::::A::::::T::::E:::RQLG:-
HQ3668A         ::::::::K::RSI:TN:::::::TAQ::::::E::T:::T:::KV:Q::E:::::::TV
HVO_0208        :::::::TD:::AIA:Q::::F::::::RS:V:::::::::::::::::::::VT::N:T
rrnAC2924       :::::::P:::KT::K::::EQ:A::::::::::V:E:::R:::::::::::::EFAA::
Hmu2746         :::::::T:::R::::::::DQ:SE:::QQ::::::S:::D:::::::::::::Q:L:GR
hla2583         :::::::LK::R:::E:::RER:G:A:V::::EA::::A:DD:::::P::::::E:A::L
Hbo1336         :::::::PD::A:::K::::::::::::QS::::::A:::D:::::::::::::::A::I
HQ2947A         :::::::LK:VKM::D::REEGVSESVVET::TSA::SQHTKTQT:::V:E::LSI:EQ:
rrnB0283        ::::::::::::W:IGN::::::T:::RET:TAT::D:SV:::R::TTV:E::LGL:AT:
Hbo2886         ::::::::::::W::KN::E::::E:::QH:::::NENAV:D:NVS:AVC:::VKI:TTT

consensus       QA----GTVTAA-------------------
#oth            5755674786845533311111111111111
Hut0272         :RARVDAAE:QP:::::::::::::::::::
NP6256A         :EVGRV:KSGDVPETEP::::::::::::::
NP0794A         RT:::RP:PQV:DD:::::::::::::::::
VNG2501         --::::::DGG:EN:::::::::::::::::
HQ3668A         :SGCRSE:N:ETEAYYQ::::::::::::::
HVO_0208        N::::::S:ES:A::::::::::::::::::
rrnAC2924       AG:GVT:AT:::DD:::::::::::::::::
Hmu2746         AGTGES:G:A::DD:::::::::::::::::
hla2583         K:::DRES:A::GD:::::::::::::::::
Hbo1336         RSEATA------:::::::::::::::::::
HQ2947A         :-::::------:::::::::::::::::::
rrnB0283        :R::RP:RLD--:::::::::::::::::::
Hbo2886         :PTQSDEWSEPTPSESALGSVPDQDFEETGR