[F] (GuaA) COG0519 GMP synthase, PP-ATPase domain/subunit 9 genomes BUD0169 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG1829 rrnAC3472 HVO_2625 Hbo2216 Hmu2478 Hut1119 hla0694 NP1970A HQ3194A

Pairwise sequence scores
Consensus score	2276	HQ3194A	VNG1829	HVO_2625	Hbo2216	hla0694	NP1970A	Hut1119	rrnAC3472	Hmu2478
1920	HQ3194A	2282	1766	1866	1883	1856	1878	1886	1801	1853
1963	VNG1829	1766	2275	1813	1806	1867	1884	1920	1925	1925
1923	HVO_2625	1866	1813	2295	2000	1916	1873	1863	1864	1872
1999	Hbo2216	1883	1806	2000	2280	1938	1921	1919	1897	1935
2041	hla0694	1856	1867	1916	1938	2267	1940	1953	1941	1934
2116	NP1970A	1878	1884	1873	1921	1940	2281	2056	2021	2094
2128	Hut1119	1886	1920	1863	1919	1953	2056	2281	2064	2080
2134	rrnAC3472	1801	1925	1864	1897	1941	2021	2064	2279	2096
2139	Hmu2478	1853	1925	1872	1935	1934	2094	2080	2096	2279

305 symbols
consensus       MVDVDEFIEEAKAEIAEAIGDANAVIALSGGVDSSTAAALAYEAIGDQLTPVYVDTGLMR
#oth            ..2234.1311421.4242.143.1.1........11.1...3.1.1..11.........
HQ3194A         ::::SV::D::I:::DA:::ED:::::::::::::VS:::::K:::::::::::::::::
VNG1829         :::::S:V:D:R:::S::L::ET:I:::::::::::::::::::V::::V::::::::::
HVO_2625        ::N::::::D:T:S:RDQ:::EH:I::::::::::V::T:::::V:E:::::::::::::
Hbo2216         ::NT:S:::::TE::Q:TV:::::I::::::::::V::::::R:::::::::::::::::
hla0694         ::ETE:::A::::::R:::::::::::::::::::V::T:::::V:::::::::::::::
NP1970A         ::EPTA::D:KI::::DDV:::::::::::::::::::::::::::::::::::::::::
Hut1119         ::::ET::P::::::DAQ:::SK:::::::::::::::::::D:::::::::::::::::
rrnAC3472       ::N::::::::::::::E:::KH:::G:::::::::::::::::::::::A:::::::::
Hmu2478         ::::ES::D:KVD:::D:V::E::::::::::::::::::::::::::::::::::::::

consensus       KGETDQIRETFDYMDSLRVVDAQDRFLDALEGVTDPEEKRHVIGEQFIREFETVARDVDA
#oth            ....221211.21.1...111.31..123.2.22......12...1..1...21.4222.
HQ3194A         ::::K:VKD::A::::::::::::::FES:A:::::::::::::::::::::EE:HAAN:
VNG1829         :::::E:::V::::::::::::S:::F:E:A::::::::::A:::::::::::::EE:::
HVO_2625        ::::E::AD::SF:E:::::::R:::F::::::V::::::K:::::::::::RE:KET::
Hbo2216         ::::EG::::::::E:::::E::::::G:::::I::::::K:::::::::::RE:K:T::
hla0694         ::::EE:::::SF:E::::IE::E::F:R:A::::::::::::::G::D::::::N::G:
NP1970A         ::::::::D:::::::::II::R:::::::S:I::::::::A::::::::::::::::::
Hut1119         ::::E:::::::::::::I:::T:::::E::::::::::::A::::::::::::::E:::
rrnAC3472       :::::E::::::::::::I:E:::::::E:::E::::::::I::::::::::::::E:::
Hmu2478         :::::E::::::::::::I:::T:::::::::E::::::::I:::::::::::::K::::

consensus       DYLVQGTIYPDRIESEGTIKSHHNVGGLPDVVDFEGIVEPMRDLYKDEVREVARALDLEE
#oth            31...............1...........1211.1.....1.1...........2.1.11
HQ3194A         :::::::::::::::::N::::::::::::::::::::::V:E:::::::::::E:::D:
VNG1829         TQ:::::::::::::::::::::::::::ER:G:::::::::::::::::::::H:G:::
HVO_2625        Q::::::::::::::::N::::::::::::::::::::::V:::::::::::::::G::S
Hbo2216         N::::::::::::::::N::::::::::::::::::::::V:::::::::::::E:G::S
hla0694         :::::::::::::::::N::::::::::::I:::::::::V:::::::::::::::G:::
NP1970A         :::::::::::::::::::::::::::::E::::::::::::::::::::::::E::::S
Hut1119         ::::::::::::::::::::::::::::::::::D:::::::::::::::::::E:::::
rrnAC3472       :::::::::::::::::::::::::::::ERI::D:::::::::::::::::::::::::
Hmu2478         :::::::::::::::::::::::::::::E::::::::::::::::::::::::::::::

consensus       IISERMPFPGPGLAVRIIGEVTEEKLAVAREANHVVEEELEEYEPWQAFAAVIGKATGVK
#oth            211...........1.121...4..23.1.2.2.1..2.11221....1...2.11....
HQ3194A         LV::::::::::::I:V:D:::R::V::::::C:I::S:TA:FD::::::::V:::::::
VNG1829         ::::::::::::::::V:::::P::V::C:::T:I::D:::A::::::::::L:R:::::
HVO_2625        ::A:::::::::::::VL::::P::VQ:::D:C::::D:T:KHD:::::::::::G::::
Hbo2216         VV:::::::::::::::V:::::::VE:::H:C::::::::::D:::::::::::G::::
hla0694         V::::::::::::::::V::::P::A::::::T::::::::::D::::::::L:::::::
NP1970A         ::A:::::::::::I:VL::::D:::::::::::::::::::::::::L:::L:::::::
Hut1119         ::::::::::::::::::::::A:::D:::::::::::::::::::::L:::::::::::
rrnAC3472       ::::::::::::::::::::::::::::::::::::::::::::::::L:::::::::::
Hmu2478         ::::::::::::::::::::::::::E::::::::::D::::::::::L:::::::::::

consensus       GDNRVHGWVVAVRSVESRDGMTARAQELDWETLQRIQSRITGENENVARVVYDVTHKPPA
#oth            .......11.1..1.............13.21...2....1.4212.1..1..1......
HQ3194A         ::::::::I:S::A::::::::::::::P::A::::::::::::DD::::L::I::::::
VNG1829         :::::::H::::::::::::::::::::E::::::L::::A:TIDE:S::::::::::::
HVO_2625        ::::::::I:S:::::::::::::::::P:D:::::::::::T:::::::::::::::::
Hbo2216         ::::::::I:S:::::::::::::::::S:::::::::::::Q:D:::::::::::::::
hla0694         ::::::::::::::::::::::::::::::S:::::::::::::::::::::::::::::
NP1970A         ::::::::::S:::::::::::::::::::::::::::::::::::::::::::::::::
Hut1119         :::::::::::::::::::::::::::I:::::::::::::::::::S::::::::::::
rrnAC3472       ::::::::::::::::::::::::::::::D::::M::::::AH::::::::::::::::
Hmu2478         :::::::::::::::::::::::::::I::::::::::::::SH::::::::::::::::

consensus       TIEYE
#oth            .....
HQ3194A         :::::
VNG1829         :::::
HVO_2625        :::::
Hbo2216         :::::
hla0694         :::::
NP1970A         :::::
Hut1119         :::::
rrnAC3472       :::::
Hmu2478         :::::