[F] (PyrB) COG0540 Aspartate carbamoyltransferase, catalytic chain 9 genomes BUD0515 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG6309 rrnAC1225 HVO_1454 Hbo0098 Hmu1563 Hut1214 hla1963 NP3518A HQ1879A

Pairwise sequence scores
Consensus score	2286	HQ1879A	VNG6309	hla1963	HVO_1454	Hbo0098	Hmu1563	Hut1214	rrnAC1225	NP3518A
1818	HQ1879A	2294	1703	1727	1804	1849	1657	1627	1669	1785
1952	VNG6309	1703	2568	1692	1846	1792	1786	1744	1834	1813
1919	hla1963	1727	1692	2357	1889	1839	1789	1693	1712	1776
2056	HVO_1454	1804	1846	1889	2294	2039	1840	1850	1865	1839
2025	Hbo0098	1849	1792	1839	2039	2293	1809	1813	1857	1839
1995	Hmu1563	1657	1786	1789	1840	1809	2278	1884	1927	1826
1939	Hut1214	1627	1744	1693	1850	1813	1884	2288	1931	1839
2035	rrnAC1225	1669	1834	1712	1865	1857	1927	1931	2292	1920
1992	NP3518A	1785	1813	1776	1839	1839	1826	1839	1920	2245

345 symbols
consensus       --------------------------MRQ-----DHLISAKQLSRDDIEAVLDRAAEIAA
#oth            1111111111111111111111111111111111..111221...5.1.31..1.12123
HQ1879A         :::::::::::::::::::::::::::H:::::::::L:TT::::E:::TI:::::A:EM
VNG6309         MLSTDAVETFDQLVVHDRKEDSSHLDR:HRVMDL::I:TS:::::A:::T::::::::D:
hla1963         ::::::::::::::::::::::::::::::::::::::T:T::::::::::::::R:V:D
HVO_1454        ::::::::::::::::::::::::::::::::::::::::SH:::E::::::::::D:D:
Hbo0098         ::::::::::::::::::::::::::::::::::::::::T::::::V::::::::D:D:
Hmu1563         ::::::::::::::::::::::::::::::::::::I::::::::R::::::::::::::
Hut1214         ::::::::::::::::::::::::::::H:::::::I::::::::S:::E:::::::::R
rrnAC1225       ::::::::::::::::::::::::::::H:::::::I::::::::G:::T:::H::D:::
NP3518A         ::::::::::::::::::::::::::::H::::::::L:::::::G:::G::::::::::

consensus       DPAAFADRHAGTVLGLLFFEPSTRTKMSFDTAMKRLGGDTVDMGSVESSSVKKGESLADT
#oth            1.41323213231.1.1........1...2212....13111..3.12..11...1.1..
HQ1879A         N:DGWEAQYS::::::C::::::::R::::A:::::::R:I:::::DN::IS:::T::::
VNG6309         ::S:::::YEN::::::::::::::::::::::::::::I::::::D::::::::T::::
hla1963         ::::Y::::::S::A:C::::::::R::::S:A::::MN:IG::D:D::::S:::::S::
HVO_1454        :::::RQ::::K::::C::::::::R::::S:::::::Q:::::P::::::::::T::::
Hbo0098         ::::WRQ:::::::::C::::::::R::::::::::::R:::::P:::::::::::::::
Hmu1563         ::S:Y::::E:SL::::::::::::::::SA::::::::I::::T:::::::::::::::
Hut1214         ::T::RQ::P:AL::::::::::::::::SASI::::::I::::P::Y::::::::::::
rrnAC1225       ::G::::::SD:L::::::::::::::::T:::::::::I::::::::::::::::::::
NP3518A         ::D:V:EK:SDKL:::::::::::::::::::::::::::::::::D:::::::::::::

consensus       VRVVEGYADALVLRHPSEGAAKMASEFVDVPLINAGDGAGQHPTQTLLDLYTIRENAGLD
#oth            ...11..2..1.....31.1121.1.1.12.12.1.....1..1.....11.1...2.11
HQ1879A         :::IA:::::I:::::::::::L:A::::I:V::::::::::::::::::::M:::V:::
VNG6309         :::I::::::::::::NQ:::Q::::::::::L:::::::H::::::::::::::::::E
hla1963         :::I:::::::::::::::::TL:A:R:S::VV::::::::::S::::::H:::::H:::
HVO_1454        :::::::::::::::::::::T::A:::::::V::::::::::S::::::::::::::::
Hbo0098         :::::::G::I:::::L::::::::::::::V::::::::::::::::::::::::::::
Hmu1563         :::::::::::::::::::::Q:::::::A::::::::::::::::::::::::::::F:
Hut1214         ::::::::::::::::M::S::::::::::::::G:::::::::::::::::::::::::
rrnAC1225       :::::::T::::::::M::S::::::::::::V:::::::::::::::::::::::::F:
NP3518A         :::I:::T::I::::::::SP:L::::::::V:::::::::::::::::M::::::::::

consensus       DLTIGIMGDLKYGRTVHSLAHALTNFDASQHFISPESLQLPRNVRYDL-HESGAQVREHT
#oth            1111..1............13..131.13...1.....1...2111..1133.241...1
HQ1879A         EI:V::A:::::::::::::A::S:::VR::::::::::::::I::::::D::S::::::
VNG6309         :::::::::::::::::::SR::::::VD:::::::::::::D:V:::EQ:::TR::::D
hla1963         :::V::::::::::::::::A:::E:::N:::::::::R:::S::F:::::T::::::::
HVO_1454        ::::::::::::::::::::E:::::::::::::::::R:::::::::::A:::::::::
Hbo0098         ::::::::::::::::::::E:::::::R:::::::::R:::::::::::G:::::::::
Hmu1563         ::S:::::::::::::::::::::V:::R:::V:::::::::S:::::::::::E:::::
Hut1214         ::S:::::::::::::::::::::::::::::::::::R::::::::::::E::TI::::
rrnAC1225       ::::::::::::::::::::::::TV::::::::::::::::S::::::::A::GI::::
NP3518A         :::::::::::::::::::::::::::V::::::::::::::S:::::::::::::::::

consensus       DLDDVLPELDVLYVTRIQRERFPDENEYRKVAGEYQIDADTLEAAKDDLTVMHPLPRVDE
#oth            32241.42..1.......3....1.1..23...1.1213341442522..11......1.
HQ1879A         :IESI:::::::::::::::::::::::QR:::Q:RV:T:I:SH:DNN::::::::::::
VNG6309         SFE:::::::I:::::::::::::::::Q:::::::LT:TH:::::::::I:::::::::
hla1963         ::EG::G:::::::::::K:::::::::HR:::::::::E:::D:P::::::::::::::
HVO_1454        E::E:::::::::::::::::::::::::::::Q::::SE::D::A::::I:::::::::
Hbo0098         E:SE:::::::::::::::::::::::::::::Q::::::D:SD:::S::::::::::::
Hmu1563         ::::::S:::::::::::K::::::S::HE:::::::::A:IREHNE:::::::::::::
Hut1214         A::T::DS::::::::::E::::E:S:::::::::R:::E:::STR:::::L::::::::
rrnAC1225       E:::I:::::::::::::A::::::S:::E:::Q::::G:::A:::::::::::::::::
NP3518A         :IES::ET:::::::::::::::::::::Q:::::R::::L::S::::::::::::::S:

consensus       IAPDVDETDHAQYFEQAHNGVPVRMALLDLLLEGDR---------
#oth            .2211.3141.3..2....11........4213756222221111
HQ1879A         :::E::T:E::A:::::::::::::::::A:IGRAK:::::::::
VNG6309         :::EI:D::::A::::::::::::::::::V:SA:GGVDDE::::
hla1963         :::::::::::T::::::::I::::::::I:::NAEGDEGMEVDR
HVO_1454        :S::I:D::::T::::::::I::::::::I::SQ:::::::::::
Hbo0098         :::E::::A::K:::::::A:::::::::M:::DN-:::::::::
Hmu1563         :DH::::L:G::::Q::::::::::::::MV::ES::::::::::
Hut1214         :DH:::A:S:::::Q:::::::::::::::V:G:ESA::::::::
rrnAC1225       ::H:::::T:::::Q:::::::::::::::M:G::Q:::::::::
NP3518A         ::A:::::E::T::K::::::::::::::EM:----:::::::::