[R] (Cof) COG0561 Predicted hydrolases of the HAD superfamily 9 genomes BUD0592 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG0718 rrnAC1620 HVO_1536 Hbo0009 Hmu2056 Hut1856 hla2215 NP1738A HQ2676A

Pairwise sequence scores
Consensus score	1694	hla2215	HQ2676A	HVO_1536	Hbo0009	VNG0718	NP1738A	Hut1856	rrnAC1620	Hmu2056
1121	hla2215	1797	1011	1071	1029	773	816	839	764	804
1197	HQ2676A	1011	1754	1156	1223	782	791	869	793	823
1253	HVO_1536	1071	1156	1712	1273	751	888	896	830	844
1244	Hbo0009	1029	1223	1273	1700	747	858	879	830	839
1021	VNG0718	773	782	751	747	1688	925	889	851	904
1085	NP1738A	816	791	888	858	925	1712	940	906	947
1190	Hut1856	839	869	896	879	889	940	1756	986	969
1069	rrnAC1620	764	793	830	830	851	906	986	1709	1074
1119	Hmu2056	804	823	844	839	904	947	969	1074	1714

245 symbols
consensus       ------------MDSMVPPLVLDIDGTLTDADGRLDPRVFDVLREWDAPVVLATGKAFPY
#oth            111111112233446531..22.1....13334321212543134.122112....22.1
hla2215         MRERKTVARRHLTSD:::::A::::::::T:S::::A:::EL:PD:::::::::::::::
HQ2676A         ::::::::MYTDA:AT:::::::::::::::P:::::::PVY:QS::::I::::::S:::
HVO_1536        ::::::::::::---::::::::::::::::::H::::A:E::PA:::::I:::::::::
Hbo0009         :::::::::::::A:D::::::::::::::EP::::::A::::PS:::::::::::S:::
VNG0718         ::::::::::::::TAD:::AV::::::SR::RSI:G::L::::G::G:::V:::::L::
NP1738A         ::::::::::::---::A::AV:::::::RP:KSI::::::AI:A::DH::I::::S:::
Hut1856         ::::::::::MAESGSA::::T:V::::::DEL:::::MGTA:::::G::::::::VL:F
rrnAC1620       :::::::::::::::DT:::IV::::::::ESRA:::H:IP:::::P:R::I:::::M:F
Hmu2056         ::::::::::::-MQET::::V:V:::::GP:QAVA::AMT::A::P::::V:::::::F

consensus       PVALCHFLGIERTVIAENGGVVLVD--DELTYTGDREAAQAVADAFVARGGDLGWGAADL
#oth            112.1312.3343.1.....1331333212657..51225122331222.222.1164.3
hla2215         ::::A::::RAE::::::::::H::::G:TAIL::A::PR::VE::RE::::P::::R:T
HQ2676A         :::::::::::Q:::::::::I:A:::ETVS:Q::S:R:::A:SV:EE:::E::::GF:D
HVO_1536        ::S:::Y::LPQ:::::::::::A:::G:V:F:::::::::A::E::::::::::D:::T
Hbo0009         ::S:::Y::L::N:V::::::::AN::G:V:::::K:R::::::E:::::::::::SF:D
VNG0718         A::::Q:A::DER::::::::AY:G:::::LHF::SR:VEQ::A::EDA:H:I:::D:::
NP1738A         ::G::E:::MPLN:::::::A:Y:EPAG:VV:N::P:G:A:::EEY::A:Y::::::V:M
Hut1856         :I::ANY::::::::::::::TF::AT:::GVH::::::::::::Y:DA:Y:::::P:::
rrnAC1620       :I:::E:::LD:::V:::::::F:EAT:::RLE::H:::L::GESYRDL:H:::F:QI::
Hmu2056         :::::Q:V:::PC:::::::::F:GES:::VFG::P::VD:FVA:YRE::HS::::NV::

consensus       ANRWRETEIAVSLDQPEELLRELAAEHG--LEVIDTGYAYHVKSPGVDKGTGLEAVAETL
#oth            3.2.....22231411232.422.33421124.2..11...2133213.16113212341
hla2215         V:::::::V:L:::AD:A::::V::AA:GDV::V::::::::::T::S::R:::R:GDA:
HQ2676A         V:K::::::::D:SAD::::::V:::FD:::T:::::::::L:T:::E::D::K::C:::
HVO_1536        :::::::::IAR:NAD:A:::AV:D:FD::V::::::F:::I:T:::E::V:::R:C::M
Hbo0009         T:Y::::::::::AAD:K::::V:T:YE::MD:::::::::::T:::E::I:FKRLC:::
VNG0718         T:::::::L:::RE::LDV:SA:::D:::::H:V:::F:::::PESMS::NA:P:::AR:
NP1738A         V:::::::L::DR:::L:P:VAI:DD::::MD:V:::::::::DA::::A::::T:::L:
Hut1856         P:::::::VIAAR:::L:P::D:::::::::::V::Q::::::::SMT::K:::T::DA:
rrnAC1620       ::::::::LV::::::L:P:E::::AR::::V:L:::F::::TD:V::::::::::CSE:
Hmu2056         ::::::::::::::::R:P:D:::ET:::::T:::::::::::::::::::::R::::E:

consensus       GYDPDEFVAVGDSENDVSTFEVAGESYAVANADDAAKAAADRVLDASYADGFLEALDRIR
#oth            345152.2.1...4..2321421.323..1...33.431.1522343231.113112343
hla2215         :IG::::::I::::::::::A::::::::::::G::RE:::I:VAD::M::TAGV:ADL:
HQ2676A         EL:::S:::I::::::::::A:::R::::G::::::QR:::EI:EN::F::TASV::::E
HVO_1536        D:::ED:::::::V::A:::R:::R:::::::::V::E:::T:::R::M::T:SV::SL:
Hbo0009         SM:::::::::::T::T:::G:V:Q::::::::E:::::::E::S:::M::T:SV:ES:Q
VNG0718         :VTAGD:::::::A:::EL::AV::::::G::::H::G::ET::SETHG::::A:V::::
NP1738A         :VV:SS:I:I::::::AELL:L::TGF::::::AH:RG:::A:T:::F::::::::::A:
Hut1856         ::E:T::::::::T:::::::A::TAI:::::::::L::::H:T::EF::::::::::VD
rrnAC1620       DL::A::L:::::V::AQM:DL:::AV::::::ET:LER::::T::::G::::::VAPY:
Hmu2056         ::A:GD:L:::::I:::A:::L::::V::::::EH:A:::::RT::R::A:::::VEPY:

consensus       D----
#oth            55442
hla2215         TRTE:
HQ2676A         SSETS
HVO_1536        EEDAA
Hbo0009         E::::
VNG0718         S::::
NP1738A         :NR::
Hut1856         AGEW:
rrnAC1620       :::::
Hmu2056         -::::