[R] (AarF) COG0661 Predicted unusual protein kinase 8 genomes BUD1046 8 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG1770 - HVO_2302 Hbo1988 Hmu2260 Hut0240 hla0893 NP1742A HQ3347A

Pairwise sequence scores
Consensus score	4144	NP1742A	hla0893	HVO_2302	HQ3347A	Hbo1988	VNG1770	Hmu2260	Hut0240
3118	NP1742A	4142	2734	2723	2738	2807	2461	2799	2759
3264	hla0893	2734	4187	2914	3007	3063	2470	2682	2484
3267	HVO_2302	2723	2914	4174	2956	3186	2508	2713	2608
3419	HQ3347A	2738	3007	2956	4131	3332	2517	2789	2684
3516	Hbo1988	2807	3063	3186	3332	4181	2593	2838	2676
2890	VNG1770	2461	2470	2508	2517	2593	3974	2677	2541
3260	Hmu2260	2799	2682	2713	2789	2838	2677	4232	3082
3089	Hut0240	2759	2484	2608	2684	2676	2541	3082	4326

586 symbols
consensus       -V--VNLRAYWRFLVVLRQFLPLIVAYARDRRRYLLFGGSRSVTAEMRRERAEILLDSLL
#oth            11222311212113215441311443131123322211331624422143..54..22.1
NP1742A         :-::-M:::::::V::AS:::::LF:::::KK:F:::::::QPS::T::R::QS:::::V
hla0893         V:TL:::::::::F::M:R:S::::::W:::K::F::::G:E:D::TQ::::A::::I::
HVO_2302        V:TL:::::::::::::Y::F::::::T::K:K::::::G:R::T:::V:::DV::E:::
HQ3347A         :-::M:::::::::::I:::F:::I:::::K:K::F:::T:::N::TQTA::::::E:::
Hbo1988         V:TL::::S:::::::VY::F:::::::::::T::::::::T:::::QSK::::::::::
VNG1770         :-::------------------------------------------::::::R::::A::
Hmu2260         :-:::::::::::V::V:H::::GLS:::::N:F::::R::D::P:Q::R::GR::::::
Hut0240         ::ES:S::S:R:::T::VE::::ALT:::::::F::::S::::SSAQ:H::::T::G:::

consensus       TLGPTFIKLGQLLSTRPDILPPEYIEELSSLQDDVPPAPWDEAKAVLEDELGPVDEAFDD
#oth            1..........2......1..22.121135...1..1.1.22225.1.311..1114124
NP1742A         R:::::::::::::::::V::::::::FER::::::::D:ER::::::SDI::IE:T:EE
hla0893         :::::::::::I::::::::::A::DV:EG::::::::::E:S:I:::::::::::T:::
HVO_2302        ::::::::::::::::::::::::::V:G:::::::A:::::S:::::A:::::E::::A
HQ3347A         ::::::::::::::::::V::A::::V:::::::::::::A:S:V:I:::::::::IY::
Hbo1988         ::::::::::::::::::::::Q::DV:::::::::::::E:T:Q:I:E:::::::V:ES
VNG1770         ::::::::::::::::::V::T::::::AE:::R::::D:A::QR:I::::::::DV::A
Hmu2260         ::::::::::::::::::V::::::D:FAQ:::R:::::::::RT::::::::::::::G
Hut0240         :::::::::::M::::::::::::VT:F:K:::R::::D::D:RV:::A:::::::R:S:

consensus       FDREPISGASLGQVYTAEYDGDDVAVKVRRPGIESLVEADLRVIRWSLPILMRFVGQGRA
#oth            .2512..........3.421144....1...21.2..1....22..12.3232.213211
NP1742A         ::T::::::::::::::RV::R:::::::::D:::::::::::::::::::::::D:A:S
hla0893         :::::::::::::::::R:E:S:::::::::K::::::::::T::::I:LVRK:T:S:::
HVO_2302        ::SD:::::::::::V:::E:EK:::::::::::D::::::::::::M:L::::I:E:::
HQ3347A         :::::::::::::::::T::D:P::::I::::::T::::::::V::::::VR::I:::::
Hbo1988         ::ND:::::::::::::Q:::::::::::::::::::::::::::::::FI:::I:::::
VNG1770         :N::S::::::::::::DV:DQQ:::::::::::::::::::A::::I::VV::::::Q:
Hmu2260         :ED:A::::::::::R::V:::A::::I::::::D:::::::A:::::::::Y:::ET:S
Hut0240         ::V:A::::::::::Y::I:::P:::::::::V:D::Q:::::L::I::V:LY::DDA:S

consensus       FSLENLADEFAKTIREEMDYNRERRMLEEIRENFADNDRIRIPEAVEERSGDRVLTMEYL
#oth            ....1.....32...1....51.222.31.23.133334211.524133.25.....1.2
NP1742A         ::::T:::::ET::::::::::::::::::G::LEA:ENV:V:D:LP:Y:SQ:::::::V
hla0893         ::::::::::::::::::::::::A::::::A::::E::::::T:F:AV::P:::::::I
HVO_2302        ::::::::::::::::::::AE:AET:V::Q:::::D:TLV:::PIP:::::::::::::
HQ3347A         :::::::::::::::Q::::D::::I:QQ::S::RSV:D::::::I:S:::S::::::::
Hbo1988         :::::::::::::::Q::::S::::I::Q:QS::NG:GT::::KP::::::P::::::::
VNG1770         ::::::::::::::::::::S::G:::T:::A::::EPD:V::TVY::Y:S::::::Q:I
Hmu2260         ::::T:::::S:::::::::G::AE::T:::G:::::::::::GV::TH:TN::::::::
Hut0240         ::::T:::::DQ:::Q::::K::A:::T:::::::GD:A::::PV::SH:TE:::::::V

consensus       PGTKINDVDELDEAGIDRTRLAETLQRVYLQMIIDDGVFHADPHPGNLAVQDDGTIIFYD
#oth            2....122231145131.232122.133.1...12..11.........1.322.321...
NP1742A         G::::SKL:D::S::V:::E::R:::Q::::::V:::A::::::::::::K::::LV:::
hla0893         :::::S:::A::D::H::NAI:::::D:::::::::::::::::::::::D:::AV::::
HVO_2302        :::::::I:A::DR:::::E::TN:::I:::::V::::::::::::::S:T:::R:::::
HQ3347A         ::::::NIE::::M:LN:::::::::E:::::::G:::::::::::::::TET::V::::
Hbo1988         :::::::LETI:ME:::::E::TR:::I::::::::::::::::::::::DEE:R:::::
VNG1770         E::::S:::T:ERR:V::SQVS:::E:A::::::E:::::::::::::::::::S:V:::
Hmu2260         ::::::::E::::LSV:::::::::::S:::::::::::::::::::::::S:::LV:::
Hut0240         E:::::::A::::K:::::::::::E:A:F:::VE:::Y::::::::::::::::LV:::

consensus       FGMSGRVDPFIQDKIVDFYVAVANQDIDAILDALIEMGTLSPEADRQVMGDVMELAIADA
#oth            ...212.11.2.11.11..31..3..2.1...1.12......21..3..12..1...1..
NP1742A         ::::::::::::E::I:::M:::R::T:::::T:::::::::D:::E::AN:::::::::
hla0893         :::A::::::::E::::::::::R::::G:::T::A::::::::::E:::N:::::::::
HVO_2302        :::H:E::::::E:::E::I::::::V:G:::T:::::::::NV::::::::::::::::
HQ3347A         :::::T:G::::ER:I::::::::::::G:::::::::::::::::E:::N::Q::::::
Hbo1988         ::::::::::V:::::::::::::::::G:::::V:::::::::::R:::::::::::::
VNG1770         ::::::::S:::::::E:::G::::::::::::::D::::::::::A::A:::::::Q::
Hmu2260         ::::::::::V::R:::::A:::S::::::::::::::::::::::::::E:::::::::
Hut0240         ::::A:::S:L::R:I:::M:::E:::::::::::::::::::V:::::A::::::::::

consensus       RGEDIEQYRVQQIIQQVEDTIYEFPLRLPRNLALVLRVATVVEGVCVTLDPEFDFISVAT
#oth            1.121.1.111..232..1..........31........1.....1....11....21..
NP1742A         :::::::::I:::::::::::::::::::P:::::::::::::::::::::D::::D:::
hla0893         S:::::::Q:N:::E:::S::::::::::PD::::::::::::::::::::::::::T::
HVO_2302        ::D:::::::N::LE:::S::::::::::::::::::::G::::::::::::::::::::
HQ3347A         :::::::::::::VD:::S:::::::::::::::::::::::::::::::::::::::::
Hbo1988         ::::::::::::::E:::S:::::::::::::::::::::::::::::::Q:::::::::
VNG1770         :::N::T::::::VGK:::::::::::::P::::::::::::::::::::::::::T:::
Hmu2260         ::::L::::::::::::::::::::::::A:::::::::::::::::::::D::::T:::
Hut0240         :::Q:::::::::::S:::::::::::::E:::::::::::::::A:::::D::::::::

consensus       DYLREEGYYEESARQIAADRGQQVQDTAESLVRVPPKLERALDRIERDNLHVRVRLEDSN
#oth            111421.13122224333132416132231322....1243..332.2123231322.54
NP1742A         ::::D:::I:::::GYVE::VGEI::FG::M::::::::S:::DLD:G:VSLQ:SF::DE
hla0893         E::K::::::QT::NL:EGA:::A:K:::A:FT::::ADDF:::AN:GD::ID:TID:GS
HVO_2302        :::T::::R:::VQK:IEGV:::G:K::Q::F::::::::V:::AD::::TLN:::::NR
HQ3347A         ::IES::::::T::KLL::A:T:T::::RA::E:::::NGV:::::::::S:D:::Q:QS
Hbo1988         :::::::::::T:KE:V::T:R:M:R:T:AMFT:::::D:V::SV::E::T:N:::::K:
VNG1770         :::A:Q::R:::I::F::GTAEEF:AA:T:VL:::::::::::KV::ED:Y::AD:::::
Hmu2260         E::::::HIAAG:K:Y:Q::AGE:R:A:::M::::::::S:::::::ED::::ADI:::D
Hut0240         :F::::::L::::::FVS::VTE:R:AGR:A::::::::TT:::::::DFY::ADI:::D

consensus       NVLDRLARRLVYGLLLAVGVLSTAILYAF--SSVRAAAVAAALTAPVAIALYRSFRKRRG
#oth            42213113.22214321524322331.232342342233223413233531121..3221
NP1742A         SAF::::K:::F:G::SAL:IAA:V::::::ADLT::LI:LGGAV:::FL:W::::G:::
hla0893         ::::K::M:IA:SV::::::::ST:::S::AQ:W:L:::VLL:A::L:V::::::::K::
HVO_2302        G:::K::K::I::IF:SF:FV::V:I::LNPE:LV:VGA:G:P::V::LL:W::::S:::
HQ3347A         ::I::::::I::::FV:::A:::::::::DQ:::LP:T:::V::L::I::::::::SK::
Hbo1988         ::::K::::I:::::::::::::::::::DQT::VP::::::::L:II:Q:::::::K::
VNG1770         R:I:A::::V:L::V::TS:PT::F::VT::AD:T:::ISG:F::A:GA:::KT::R:N:
Hmu2260         G::E:MT:::IL:MI::S:T::::L:::A:::TDE:T:::GVG:LA::GVT:L:::RSK:
Hut0240         DL::I::T::IL:MIA:G:LV::SV::SL:::T:::TLL::LV:TVSLF::::::::::S

consensus       LRTTPQFTRQNMRQRRGDD---------------------------
#oth            2222......311212343232333223312321212222222221
NP1742A         ::GK:::::::L:K::::E:::::::::::::::::::::::::::
hla0893         I:::::::::G:KK::D:-:::::::::::::::::::::::::::
HVO_2302        I::::::::::LKE::RE-:::::::::::::::::::::::::::
HQ3347A         VQ:K::::::S::E:::R::::::::::::::::::::::::::::
Hbo1988         :K::::::::::::Q::E::::::::::::::::::::::::::::
VNG1770         :QAS:::::::L:E:D::GDDGGTALARSGSQIEADDAGTATNGD:
Hmu2260         ::A:::::::S::::ESA:DAGYAS::SYGPDEE::::::::::::
Hut0240         I:A:::::::K::::ESNEGTESPPIGADGPIEEEDTKVAEEDRWT