[H] (CobJ) COG1010 Precorrin-3B methylase 8 genomes BUD0962 8 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG1555 rrnAC3005 HVO_B0058 Hbo1623 Hmu1995 - hla2068 NP1116A HQ3034A

Pairwise sequence scores
Consensus score	2178	HQ3034A	rrnAC3005	HVO_B0058	Hbo1623	NP1116A	VNG1555	Hmu1995	hla2068
1781	HQ3034A	2166	1689	1594	1613	1712	1602	1699	1667
1889	rrnAC3005	1689	2551	1703	1728	1782	1705	1854	1781
1805	HVO_B0058	1594	1703	2275	2009	1669	1594	1678	1732
1853	Hbo1623	1613	1728	2009	2186	1709	1620	1700	1749
1921	NP1116A	1712	1782	1669	1709	2163	1739	1834	1832
1828	VNG1555	1602	1705	1594	1620	1739	2105	1779	1762
1977	Hmu1995	1699	1854	1678	1700	1834	1779	2353	1887
1982	hla2068	1667	1781	1732	1749	1832	1762	1887	2182

332 symbols
consensus       -----------------------------------DMPAEDPDDYGTLYVVGIGPGLPHA
#oth            111111111111111222122333324344433345552444413...11........33
HQ3034A         ::::::::::::::::::::::::::::::::::MSTT::TTS:A:::::::::::::E:
rrnAC3005       MRKRRCTHHAPQYRDSTGGPRRPRMSSDGRQSTAAAAE:TR:A::::::::::::::::D
HVO_B0058       :::::::::::::::MNDGREPTEPATESATEPAA:DRD:V:::::::::::::::::DH
Hbo1623         ::::::::::::::::::::::::::MSEGAETTT:SH::V:::::::::::::::::DH
NP1116A         :::::::::::::::::::::::::::::::::::-:T:S:GESM::::I::::::::::
VNG1555         :::::::::::::::::::::::::::::::::::MSD:NEAA:::::::::::::::GG
Hmu1995         :::::::::::::::::::::MAAESPDDSDASGEKR::SESR:H:::S:::::::::::
hla2068         :::::::::::::::::::::::::::::::::::-::EY::::::::::::::::::::

consensus       MTQRAKDVIQTADCVIASNLYQEFLRRDGTLPPE-----ADADDG--------V-ERPDG
#oth            ..12.12114.1..111.........3.....1311223253.2.212212123332221
HQ3034A         :::Q::T::E::::::V:::::::::A:::::ET::::T::I:::::::::::KYT::::
rrnAC3005       ::::::::::::::I:::::::::::K::::::QSAELDGET:::EIAGEEGA:L:::::
HVO_B0058       ::K:::EL:S:S:::V::::::::::D::::::::::::-GS:::::::::::-:-----
Hbo1623         ::::::E::::S:::V::::::::::D::::::::::::-:S:::::::::::-:-----
NP1116A         :::::R::::::::::::::::::::::::::::::::::ET:G:::::::::TAT::N:
VNG1555         ::::::::VR:::::V:::::::::::::::::-:::::--::A:::::::::-:::::-
Hmu1995         :::E:::::R::::::::::::::::K:::::::SAAIE:A::G:A:DSESGT:L:::N:
hla2068         ::::::E:VA::::::::::::::::::::::::::::D:V::G::::::::::AAKA::

consensus       T-QELVRSSMGRQVELAREAFERVRDGEDVAHVSGGDPNVYGKSDLVFTMAEAEDATDVP
#oth            231122..1..3.1..12.......3.1111...............111..3313.2.1.
HQ3034A         :E:::L:::::S:::::I:::::::E:Q:I::::::::::::::::L::::R::E:::::
rrnAC3005       SR:T:I:::::K:::::::::::::A:::I::::::::::::::::L::::D:D::D:::
HVO_B0058       -:P:V::::::K::::T:::::::::::::V::::::::::::::::::::KGDE:::::
Hbo1623         -:P:V::::::Q::::T:::::::::::::::::::::::::::::::::::SD::::::
NP1116A         :E::I::::::::::::::::::::N::::::::::::::::::::::L::DE:::D:I:
VNG1555         -:::V:::T::::I:::K:::::::::::::::::::::::::::::YL:::E:A:Y:::
Hmu1995         :R:::::::::::I:::::::::::A::::::::::::::::::::LY::::::G:::::
hla2068         ST::I:::T::Q:::::K:::::::::QT::::::::::::::::::Y::::::::D:::

consensus       IEIVPGVTAALGGAANLGAPLSNDFCTISLSDKWRGWDEIEEKLRAAAISGFVIVLYNCW
#oth            ..11.......1...11..........1.........2...........11.11......
HQ3034A         ::VI:::::::::::::::::::::::V:::::::::A:::::::::::A::I:::::::
rrnAC3005       :::::::::::S:::::::::::::::::::::::::::::::::::::::::V::::::
HVO_B0058       :::::::::::::::MM::::::::::V::::::::::::::::::::::::::::::::
Hbo1623         :::::::::::::::MM:::::::::::::::::::::::::::::::::N:::::::::
NP1116A         ::V::::::::::::::::::::::::V:::::::::::::::::::::A::::::::::
VNG1555         :::::::::::::::::::::::::::::::::::::E:::::::::::::::V::::::
Hmu1995         ::V::::::::::::::::::::::::::::::::::::::::::::::::::V::::::
hla2068         :::::::::::::::::::::::::::V::::::::::::::::::::::::::::::::

consensus       RDYERAIDVIREERADDVPVAIFNDAGRGEAGRNLDDETHTITTLGAATDHDDEVGGMGT
#oth            .1.1..1212.........11.2..1..13....211..21111.13224.122.....2
HQ3034A         :::::::E::::::::::::::::::::ET::::::::::::CQ:DE::T:::K::::::
rrnAC3005       ::::::V::L:::::::::A::V::S:::::::::::::E::::::ELPE:::K:::::S
HVO_B0058       :N:::::::V::::::::::G::::::::::::::::::FSV::::D:KA:::D::::::
Hbo1623         :N:T::::IV::::::::::G::::::::::::::::::FS:::::D:KS:::D::::::
NP1116A         :::::::E::::::::::::::::::::::::::V:::::::::::::::::EK::::::
VNG1555         :::::::G:L::::::::::::I::::::D::::T:G:::::::::SV:::SG::::::A
Hmu1995         :::::::::L::::::::::G::::::::::::::E::::::::::::::::::::::::
hla2068         ::::::::::::::::::::G::::::::A:::::::::::::::::::E::::::::::

consensus       SILVGTHETEVWENDYRKHLVTPRGGRDVDDF
#oth            ..21.11.142.2..2332........1.1..
HQ3034A         ::I::N:::T::R::T:AF::::::::::E::
rrnAC3005       ::V:::::::::R:::QEF:::::::::::::
HVO_B0058       :::I::::::P:S:::QTY:::::::::::::
Hbo1623         :::I::::::P:S:::ETY:::::::::::::
NP1116A         ::::::::SHE:::::ETY::::::::E:E::
VNG1555         :::I::D::A:::::H:::::::::::::E::
Hmu1995         :::::N::::::::::G:::::::::::::::
hla2068         :::::::::N:::::HG:::::::::::::::