[HR] (ThiH) COG1060 Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes 9 genomes BUD0463 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG1937 rrnAC3279 HVO_2201 Hbo1911 Hmu2457 Hut2005 hla1355 NP2398A HQ3125A

Pairwise sequence scores
Consensus score	2853	NP2398A	VNG1937	Hut2005	rrnAC3279	Hmu2457	hla1355	HVO_2201	Hbo1911	HQ3125A
2187	NP2398A	2795	1903	2005	1989	2012	1741	1849	1827	1746
2257	VNG1937	1903	2908	1988	1940	2076	1913	1861	1922	1869
2298	Hut2005	2005	1988	2892	1937	2085	1890	1922	1903	1835
2213	rrnAC3279	1989	1940	1937	2688	2230	1815	1812	1811	1729
2379	Hmu2457	2012	2076	2085	2230	2885	1944	1903	1978	1822
2226	hla1355	1741	1913	1890	1815	1944	3031	2177	2144	2026
2223	HVO_2201	1849	1861	1922	1812	1903	2177	3018	2180	2081
2268	Hbo1911	1827	1922	1903	1811	1978	2144	2180	3099	2237
2125	HQ3125A	1746	1869	1835	1729	1822	2026	2081	2237	3036

420 symbols
consensus       -------------VFPGADEYDVDITIDDAAVERLLSVTPADVS------AASSLSFARN
#oth            223323333111134422421234443345542221443.2.141111113144.112..
NP2398A         :::::::::::::-MF::AD:G:::QV::GDT::::::::D:::::::::::E::::C::
VNG1937         :MWGCAVTE::::TQF:G:::::SVSVSE:::::A:D:R::::A::::::P::::T::::
Hut2005         LTDVIRNPD:::::I:::E:::::V:::P:ER::::::G:E::AGPGEDGGPDH::::::
rrnAC3279       :::::::::::::-------------------------M:E::E:::::::::A::YC::
Hmu2457         ::::::::::::::I:::SD::LSLS::EE:I:Q::QT::::::::::::::P:::::::
hla1355         :::::::::::::::AA:E::GIE:EP:PER::::::I:::::E::::::P:DR:T::::
HVO_2201        :::::::::::::M:T:::::G::L:::::D:::::A:::D:AD:::::::PA::::S::
Hbo1911         VTRFCTSETHPVL:::A::::::R::P::D::::::A:::D:::::::::P::E:T:S::
HQ3125A         :::::::::::::M::A:A:::I:F::PSTSIN::::A:::::N::::::S:AA:T:S::

consensus       VFVPLTTACRYTCTYCTYYDPPGEASLLSPEEVRETCRRGADAGCTEALFTFGDDPDDRY
#oth            ..2..........1.....12..1.3.123311.34224...............4..1..
NP2398A         :::::::::::::::::::E:::Q::::::A:I:DI:E::::::::::::::::::::::
VNG1937         ::::::::::::::::::::V:::::::T:::I::Q::V:::::::::::::::Q:::::
Hut2005         ::I::::::::::::::::::::Q:::::::D:::I::E:::::::::::::::::::::
rrnAC3279       ::L::::::::::::::::::::Q:E:MDR::I:::::::::::::::::::::::::::
Hmu2457         ::L::::::::::::::::::::Q:E:MTT::I:::::::::::::::::::::::::::
hla1355         ::::::::::::::::::::V:::::::::::::QR::V:::::::::::::::E:::::
HVO_2201        ::::::::::::::::::::V::::T:M:LD::::VV:T:::::::::::::::A::E::
Hbo1911         ::L:::::::::::::::::V::::T:M:::D::::L:V:::::::::::::::E:::::
HQ3125A         ::I::::::::::S::::::I::::A::::Q:::HRVQL:::::::::::::::R:::::

consensus       TAIHDQLAEWGYDSIHEYLREACEIALEEGLLPHSNPGDQTREQMARVADLNASMGVMLE
#oth            22114..31..211.23..341.22.112...1.1....1.2321251122...1.....
NP2398A         ER::G::::::H::::D::::::D:::DC::::::::::::::::G::::::::V:::::
VNG1937         ::::E::G::::::::::::A:::::::A:::::A:::::::A:::T:::V:::::::::
Hut2005         D::Y:::::::H::::T:::::::::::::::::A:::::::::::E:::::::::::::
rrnAC3279       ::V::::::::H::::::::::::::::::::::A:::::::::::H:::::::::::::
Hmu2457         ::V:::::::::E:::T:::R:::::::::::::::::::::::::T:::R:::::::::
hla1355         ::V::::D:::::::L:::YR::::::::::::::::::L:EAAF:DLREV:::::::::
HVO_2201        :E::R::D:::::D:LD::AA:::V::D:::::::::::L:::AF:DL:P::::::::::
Hbo1911         ::::E::S:::::D:LA:::DC::M:M:::::A::::::L:ESAFE:L:PV:::::::::
HQ3125A         E:::A::DV::F:D:I:::NMC:H:::::::::::::::L:LTEFEQL:PV:::::::::

consensus       TTADVQAHGGPRRKTPGQRLNTIRAAGELGVPFTTGILVGIGEDWRDRAESLLAIRELHE
#oth            ..1114..2.3.1.3.1...2.122..33.1.....1.2....2131....1...112..
NP2398A         :::E:R::::::A:E:::::A::AT::::::::::::::::::TA::::::I::::::::
VNG1937         ::::::::::::A:S:E:::H::DV::D::::::::::::::::::::::::::::A:::
Hut2005         ::::LE::S:S:::E:::::A:::T::::::::::::::::::::A:::::::::AA:::
rrnAC3279       ::TE::::::::A:N:::::::L:V::::::::::::::::::::HH::::::::::M::
Hmu2457         ::::::::::::A:N:::::::L:V::::::::::::::::::::T:::::I:::AAM::
hla1355         :::::D::S:G::::::::::::::::RQ:::::::::L::::::::::::::::::I::
HVO_2201        :::::A::S:S:::::::::::::::::V::::::::::::::T::::::::::::A:::
Hbo1911         :::::R::S:G::::::::::::::::KV:::::::L:I::::T::::::::::::::::
HQ3125A         :::::D::A:T::::::::::::::::KA:I:::::L::::::E::::::::::::::::

consensus       RYGHVQEVIVQPVVPNERWDGESPSLETMRRVVAMARAALPAEVSVQVPPNLAPARDLLD
#oth            .12.1..1.1.1.23.2.12424.323.1..21....13..4311..1....23212.21
NP2398A         ::::I::I:::::SN:D::QQG::E:::L::AT:::::G::::I:::S::::::V:E:::
VNG1937         :HD::::::::::R::A::Q::P:GA::::::::::::V:::::G:::::::TDV:G:V:
Hut2005         ::N::::::::::S::::::R:P::::::::T::::::G::ET::::::::::RT:::::
rrnAC3279       ::::I::::I::::E::::Q:G::D:A:::::T::::::::E::::::::::::::::T:
Hmu2457         ::::::::::::::D::::::G::D:A:L::AT:::::G:::D:::::::::::::E:V:
hla1355         :H:::::::::N::::::S:F:K:D:A::::::::::::::P::::::::::S::A::V:
HVO_2201        :::::::::::N::::::S:Y:R:::D::::::::::V:::E::::::::::SA:A::VA
Hbo1911         ::D:I::::I:N::::::SSFDQ::V:::::A:::::V:::D::::::::::S:T:E:::
HQ3125A         ::D:I::::I:N::::::S:F:Q::VS::::::::::VC::KSI::::::::S:T:E:::

consensus       CGVDDLGGVSPVTDDHVNPDYAWPALDELRAIADAAGVPLRERLPVYDRFLP--------
#oth            ..1..........3.11..2.2..1.31.431.25121..4....112112143411111
NP2398A         ::::::::::::::::::::::::::R::EN::EE:::::E:::::Q::YA-::::::::
VNG1937         :::::::::::::K::I::::::::::::S::::H::::::::::::E::::::::::::
Hut2005         ::::::::::::::::::::::::::::::::::D::::::::::::::YV-::::::::
rrnAC3279       ::I::::::::::V::I::E:E::::Q::T:V:E::E:::S:::::::H:V-::::::::
Hmu2457         ::I::::::::::V:::::A:E::::Q::::V::H:D::::::::::E:::-::::::::
hla1355         ::I::::::::::::Y::::::::D::G::TV:::G:M:::::::T:A::::DGL:::::
HVO_2201        :::::::::::::::Y:::::E::::R::AD:::E::::::::::::E::::NGALGPAD
Hbo1911         :::::::::::::::Y:::::K::::Q:::D:::KGD:::Y::::::E:Y::ERY:::::
HQ3125A         :::::::::::::E:YI:::::::::S::TD::SS:::::H::::::::Y::KQI:::::

consensus       -------------DDEWLSERIRAAIEADNVHGRRYRSV-ARGDGPL-V-----------
#oth            2123333243544243.2354153234414421513242324342135444421111111
NP2398A         :::::::::::::AS::::P::QS:::::SEA:::::R:LESV----:-:::::::::::
VNG1937         :::::::ADGGTA::G:V:Q::WR:::D----:D::EA:R:E-----:-:::::::::::
Hut2005         ::::::::::::::ED::::QVL:TVST-------VT:TDET:T---:-:::::::::::
rrnAC3279       :::::::::::::::G:::AP:E:::::::DA:D:F::ILD::VN:VTL:::::::::::
Hmu2457         ::::::::::::G:EA:::::V:::::R:G:::E:F:A:RD::EN:AG:GGR::::::::
hla1355         RPSDTEPAAPPAGR:A:IPPAV:DRMR::DP::::L:G:::::::::A:RGD::::::::
HVO_2201        DPGESGGAPAAAP:R:::RGP:TDRLA::D:::::F:N:::::::::SIPR:::::::::
Hbo1911         :::RRDDFDGVET:R::::D:V::::D::::::K:::G::::R::::T:GSAD:::::::
HQ3125A         :::RREGFTGHSA:GG::A:Y:TD:::S:G:::Q:::::::CR::::NTNHSISAGESAD