[ER] (Tdh) COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases 7 genomes BUD1287 7 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG0446 rrnAC0917 HVO_1083 Hbo0588 Hmu1593 - hla2519 - HQ1663A

Pairwise sequence scores
Consensus score	2729	VNG0446	rrnAC0917	Hmu1593	HQ1663A	hla2519	HVO_1083	Hbo0588
1868	VNG0446	2710	1552	1476	1571	1651	1663	1703
2094	rrnAC0917	1552	2969	2063	1657	1707	1859	1809
1994	Hmu1593	1476	2063	2765	1598	1737	1754	1750
1988	HQ1663A	1571	1657	1598	2739	1804	1750	1874
2282	hla2519	1651	1707	1737	1804	3006	2008	2022
2260	HVO_1083	1663	1859	1754	1750	2008	2736	2058
2220	Hbo0588	1703	1809	1750	1874	2022	2058	2748

394 symbols
consensus       -------------------------------MKAIAVSRGDDEPVLIEKPRPEPDPGEAL
#oth            1111112222222222222122222222222.41121522324.423111..2.43.11.
VNG0446         ::::::::::::::::::::::::::::::::D::V::KA:RT:R:VDR:::D:T::SV:
rrnAC0917       ::::::MRPSASVGQRPEERLNPQCSHSLPG::V:G:T:D::G:Q:L:RE::S:::::::
Hmu1593         ::::::::::::::::::::::::::::::::::V:IR::S:::E:::::::::KH::::
HQ1663A         ::::::::::::::::::::::::::::::::Q::::::DSKG:IC::::::::E:::::
hla2519         VCDEEKPAVGSCRFFTHNKRNLLVTDCQGHC:N::::YD:A::::VT:::::::A:::::
HVO_1083        :::::::::::::::::::::::::::::::::::::E::E:K::V:::::::::A::::
Hbo0588         ::::::::::::::::::::::::::::::::R::::KK:ERR:::VD::::::ET::::

consensus       VRTLRVGVDGTDHEVIAGSHGGFPEGEDHLVLGHEAVGVVEDPNDTGLEAGDVVVPTVRR
#oth            1......1......112.21.12.211.1111....1...21.22.3123.23.1.1...
VNG0446         ::::::::::::::::::T::::::DA:E:::::::I:::A::T::RFS::QL:A:::::
rrnAC0917       :::::::::::::::LN:::::::D:A::MI::::::::::E::G::::::Q::A:::::
Hmu1593         :::::::::::::::LS::::::::::::M:M::::::::::::G:::DE:QY:::::::
HQ1663A         I::::::I::::::I::::Y:EY:AD:::::::::::::::::GT::::R:E::A:I:::
hla2519         ::::::::::::::::S:::::S::::::::::::::::::E:T::PF:V::I:::::::
HVO_1083        ::::::::::::::::::G:::::::::::::::::::::V:::::E::E::I:::::::
Hbo0588         ::::::::::::::::S:G:::::D:::::::::::::::::::G:RF::::::::::::

consensus       PP-NGTNEYFRRGEPDMAPDGEYHERGIVGAHGFMAEYFTSPADFLVPIPASLAELGFLV
#oth            212224221.3111....12.4.4....2.31.11111.1.2223.1521623144.112
VNG0446         :R:GDPTPQ:D::Q::::AP:T:V::::D::D::::D:::::::A::AL:D:::AH:::T
rrnAC0917       K:NGE::::::::::::::::::T::::::D:::::::::::::::::V:K:V::Y::::
Hmu1593         K:NGE:::::::N::::::::::F::::::E::Y:S::::::::::I::E:EI:PY:IF:
HQ1663A         S::::ESV::D::::::::E:S::::::I:S::YFS:F:::Q:QH::S::S:::QV::::
hla2519         :::::A::::A::::::::::Q:::::::::::::::::::::E:::E::PA:::W::::
HVO_1083        ::AS::::::EENQ:::::::M:A:::::::::::S::::::S:Y::R::R:Q::::::I
Hbo0588         :::::G::::E::::::::E:M::::::::E::::::::V:HEQY::Q::E::TD::::I

consensus       EPLSITEKAIEHAYASRSAFDWEPESALVLGNGSLGLLTLAML---DDGYDRLYCLGRRD
#oth            ..2.221..4.1.3.1.12.2.3.3..31....1....111513133332123..1...2
VNG0446         ::V:VA:::::L:L::::::::R:D::::::::::::::::I:A:AR:DTET:::::::S
rrnAC0917       :::::::::N:::::T:EP:::R:D::C::::::::::::W::::::QE:::T::V::::
Hmu1593         ::::N::::L:::R:T::::::Y::::A:::::P::::::WQ::::TQEF::T:::::::
HQ1663A         ::::VVN::::L:T::::S:T:::T:::::::::::::M::HIT:ST:T:E:C:::::::
hla2519         ::V::A::::::::::::::H:::::::I::::::::::V:T:::::::F::I::::::E
HVO_1083        ::I::::::R::::::::::::N:S::::::::::::::::::RAD:K::ED::::::::
Hbo0588         ::I::::::V:L::::::S:T::::::I:::::::::::::L:R:DKL::::::::::::

consensus       RPDPTIDIIERLGATYVDSRETPVDEIPAAHEPMDFIYEATGYAPHAFDTVDALAPNGVG
#oth            .....111.13211..11.12...442.322141.312....211..13214..111..1
VNG0446         ::::::::::::::::I:::T:::AD:::::Q:V:MV:::::H:K::::AI:::::A::A
rrnAC0917       :::::V:::DEI:S::::::::::::L:G:Y:A::Y::::::F:::::Q::K::DQ::::
Hmu1593         ::::::EF:DEV::::I:::::::::::DE::G:::::::::::::::E::Q::::::::
HQ1663A         ::::::::::::::::::::K::::M::STY:S::::C::::H:::::K:I:::::::::
hla2519         ::::::::::S:D::::N:N::::PSV:::::::::VF::::::::::E:IE::::::::
HVO_1083        ::::::::::K:::::::::::::E:::G:::D:::::::::FPK::IQS:Q:::::::A
Hbo0588         ::::::::::K:::::::::::::SAV:DEF:S::LV:::::::K::::S:R:::::::A

consensus       ALLGVPGS-WEFEIDGGALHREIVLHNKALVGSVNSHVRHFEAAVDTLAALPEWFLDDLV
#oth            2...1.33113..111142.223..1..113.1..1234..3413332443132131311
VNG0446         ::::::AAG:T::VP:SD:::SL::E:::V::::::NA:::R::A:::::::D:LC:AI:
rrnAC0917       V:::I:EP:::::V:::S::N:::::::C:I:T:::::S:::D::E::QE::A:L:::::
Hmu1593         ::::I:::::D::::::S::ND::::::C:F::::AGI:::AEGAAVVE:M:DDL::H::
HQ1663A         ::::::E::SS:::::::::N:L:::::::I:::::NIT::KT:S:D:QTF::::I:S:I
hla2519         :::::::D:::::::::R::::F:::::::::::::GYE:::::::S:SRFS:T::::::
HVO_1083        ::::::SD:::::V:A::F:::M:::::::::::::::K:::::TV:FTK::R:::R:::
Hbo0588         T::::::::::::::::EI:K:::::::::L:::::::K:::S:::::::Y::::T::::

consensus       TGVHDLDEFEAAFE-DDDTTIKTAVEFDTY----
#oth            .3.32233123..3111112..121113241111
VNG0446         :::::TAA:AD::R::GE:S:::::Q:::R::::
rrnAC0917       :T:T:PEHV:::::::G:DQ::AV::::SL::::
Hmu1593         :T:T:PENV:P:::::G:DQ::AI:::ESP::::
HQ1663A         :D:YP:S::RY::DNN:::::::::QLSA:EER:
hla2519         ::::G::::::::A:::::::::::::G::EER:
HVO_1083        ::::P:S:::::::::::::::::I::G:V::::
Hbo0588         :S:C:::N:A:::::::::::::::Q:S::EERR