[R] (PhnP) COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I 9 genomes BUD0513 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG2060 rrnAC2820 HVO_1905 Hbo1784 Hmu3128 Hut2933 hla0742 NP2250A HQ3105A

Pairwise sequence scores
Consensus score	2150	Hut2933	NP2250A	VNG2060	HQ3105A	hla0742	HVO_1905	Hbo1784	Hmu3128	rrnAC2820
1560	Hut2933	2254	1441	1316	1344	1422	1393	1415	1328	1408
1686	NP2250A	1441	2150	1422	1419	1470	1512	1468	1432	1432
1656	VNG2060	1316	1422	2110	1413	1505	1463	1525	1379	1301
1666	HQ3105A	1344	1419	1413	2171	1562	1493	1589	1286	1348
1790	hla0742	1422	1470	1505	1562	2157	1652	1642	1385	1401
1777	HVO_1905	1393	1512	1463	1493	1652	2119	1701	1398	1383
1807	Hbo1784	1415	1468	1525	1589	1642	1701	2125	1434	1415
1623	Hmu3128	1328	1432	1379	1286	1385	1398	1434	2153	1481
1577	rrnAC2820	1408	1432	1301	1348	1401	1383	1415	1481	2272

299 symbols
consensus       MRVTLLGTGDTTGTPTVGCDCDTCEAARER------------------GVERTRFSVHVE
#oth            .4..............12.3.31.44..31122112221211222221.11.1....114
Hut2933         :E:::::::::::::::::G::V::Q::DPDDALREQLRDRGVEVGDR:::::::::::R
NP2250A         :E::::::::::::::PS:K:E::QR::::::::::::::::::::::::::S::::::H
VNG2060         :K::::::::::::::P::::A::Q::::::::::::::::::::::::::::::::::A
HQ3105A         :L:::::::::::::::::::N:::H::Q::::::::::::::::::::I::::::::I:
hla0742         ::::::::::::::::::::::::A:::::::::::::::::::::::::S:S::::::A
HVO_1905        :::::::::::::::::::::E::L::::::::::::::::::::::::I:::::::::Q
Hbo1784         :::::::::::::::::::E::::RE::A:::::::::::::::::::::::::::::::
Hmu3128         :Q:::::::::::::::::::A:::R::D:::::::::::::::::::::::::::::::
rrnAC2820       :E:::::::::::::::Q:::::::R::DPDEELRANVRERGIDPTG:::::S::::A::

consensus       NERTGESLLIDFSPDFRQQFLRED-VPLPDAAVITHIHFDHLDGLGNAYRLFDDLPVHAA
#oth            23332121.1.2.....4...4531122..12211.1....1.....2..14232112.1
Hut2933         ::::D:T::::A:::::T:::::::LDA::::::S:V::::::::::F:::TR:M::Y::
NP2250A         :D:::::::V:A:::::S:::SN:::D::::I::S::::::::::::::::LE:V::F::
VNG2060         D:AS:DA::::::::::A::::T:ALS::::G:V::V::::::::::::::::::::Y::
HQ3105A         :P:RN::I:::::::::::::QRN::SF:::GI::::::::::::::::::C::::I:::
hla0742         :::::::::V:::::::S:::DN::::::::GIV:::::::::::::V:::V:G:::::P
HVO_1905        :::::::::V:::::::H:::TQ:::::::E:LV:::::::::::::V:::L:::S::::
Hbo1784         :D:::::::::::::::::::THE:::::::GL:::V::::I::::::::V:::::::::
Hmu3128         R-VN:D:::::::::::::::::S:::::::::V::V::::::::::V:::V:S:::Y::
rrnAC2820       :DT::::::V:L:::::H:::::S::::::::I::::::::::::::::::::E::::::

consensus       DETDPATGESVAETVRSKYDYL-DRISVRARTPFEPFEACGFEVTLVPVDHPPLLCYGLV
#oth            411..4.221.132124112..1.51414433.234.341.11121...3....31..14
Hut2933         G:V:::::Q:::QS::ER::::::V:D:K::D:::S:RVA:LD:::::::::::S:::::
NP2250A         ::V::::::::::::GD:::::::A:T:EP:S::::::T::::::::::E::::V::::H
VNG2060         TD:::T:::::::::AG:::::::S:AL:GVA:RRS:A:A::D:::::::::::::::V:
HQ3105A         N::::Q:T:T:::::AR::S::::QVT:NPHS:::V::I::L:IQ:::::::::Y:::V:
hla0742         S::::::D::::::I:::::::E:::G:HS:D::D:::S:::::RF::::::::::::V:
HVO_1905        ::V::V::::::DAI:::F:::::::::ED:::::S:R:::LD::F:::V::::V:::VA
Hbo1784         :::::K::Q::::::A::F:::::::::::Q::::T:RT::LD::::::E:::::::::T
Hmu3128         :::::Q::T::VG:I:DR:H:::::::::G::::QR:::A:::::::::V::::VS:::R
rrnAC2820       :::::V:D:::::A:::R::::::TV::H:Q::L:::TVA:::::::::T:::::::::R

consensus       IEDPETGAKLSLSGDTSYAIPEASRDVLRDPDLLLADGIVPASLCEHHPAGGDHHDDDGV
#oth            112242113.121..13.3113412211321..22111.11145142..3..415242.2
Hut2933         V:::::::::::::::::EV:Q::::A:AGA::::V:::L::DR:DT:::::S::::E::
NP2250A         ::::::::T:A::::SN:::DD:::::::N:::FF:::::::AY::Y:::::::A:A::T
VNG2060         V:--RA::::AV::::T:::::::::AM::::::V:::::::H:TH:::K::R:P:A:::
HQ3105A         ::::V:DT::::::::::GV:SE:Q:A:SN:::F:::A:::::M:::::L::K::NK:::
hla0742         ::::::::::::T:::::DV::R:::A:A:A::::::A:::::::D:::I::R:EGP:::
HVO_1905        ::::::::::::::::T:::::::::::::::::::EA:::::V::Y::I:::DY:E:::
Hbo1784         :::S::::::::::::::G:::D::S::S:::::::EA:::::::Q:::L::K:F::E::
Hmu3128         VD::DS::S:AI::::::::D:NA:E:::GA::A:VE:::H:D::S::::::::Y::A:R
rrnAC2820       ::E:Q:::V::I::::C:DV:DR:KS::TGA::A:VE:::HPEA::Y::K::T::NE:::

consensus       PRTFGTKHMTREGARALADDLDADRTRLVHTAHYYPADEAFEDPLAVDGERFEL-----
#oth            21.1.1....32..421222131242.3..32.13.213..322312..1425.11111
Hut2933         :M:Y:S::::I:::QR:SEE:::GEL:I::LS::L:VET::DV:::::::::V::::::
NP2250A         Y:::::::::V::::R::::::::DY::::LS::I::::::D:DM::::::::::::::
VNG2060         ::::::::::::::L::G:::::::::V::A:::::VE:::A:EI:::::TIR::::::
HQ3105A         ::::::::::::::CD::EA::::K::F:::G::::::::::::::I:::EYR::::::
hla0742         :::::S::::::::L::::E::::::::::L::F::P:::::E:::::::VY:::::::
HVO_1905        A:::::::::::::I::GEE:NT:E:::::V:::::::::::E:::::::VYD::::::
Hbo1784         ::::::::::::::L::::::N:EQ:::::::::::VE::::E:::::::VYK::::::
Hmu3128         ::::::::::LT:::::::::A:::Y:I:::::FV:PEQ::R:DV::::Q::::AGAKR
rrnAC2820       ::::::::::LP:::DF:A:IE::DY:I::::::V:::R::A:DIGL:::Q:M::::::