[K] (-) COG1378 Predicted transcriptional regulators 7 genomes BUD1183 8 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG1903 rrnAC3310 HVO_2349 Hbo2033 Hmu2284 - hla0613 hla0997 NP2518A -

Pairwise sequence scores
Consensus score	1986	hla0613	VNG1903	rrnAC3310	Hmu2284	NP2518A	hla0997	HVO_2349	Hbo2033
946	hla0613	2787	646	764	770	850	803	866	875
1050	VNG1903	646	1714	830	764	835	846	909	865
1442	rrnAC3310	764	830	2021	1369	1199	1187	1234	1214
1427	Hmu2284	770	764	1369	2009	1250	1158	1271	1213
1476	NP2518A	850	835	1199	1250	1980	1248	1306	1322
1461	hla0997	803	846	1187	1158	1248	1988	1296	1388
1659	HVO_2349	866	909	1234	1271	1306	1296	1985	1524
1600	Hbo2033	875	865	1214	1213	1322	1388	1524	2017

382 symbols
consensus       ------------------------------------------------------------
#oth            111111111111111111111111111111111111111111111111111111111111
hla0613         MSGSPLTVSLAATSAVPATSRQQTSATTAIFRIRLISVIRGRPRRRNTLREPLETSYQFP
VNG1903         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
rrnAC3310       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hmu2284         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP2518A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
hla0997         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HVO_2349        ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo2033         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       ------------------------------------------------MASLRDLGLSEY
#oth            111111111111111111111111111111111111111111111122142111111121
hla0613         EIYCRSVGSLSSVWGARIRIPFEYRRIHAKTKFSFSATHLNILSVDRC:E::::::::S:
VNG1903         ::::::::::::::::::::::::::::::::::::::::::::::::------------
rrnAC3310       ::::::::::::::::::::::::::::::::::::::::::::::MG:S::::::::::
Hmu2284         ::::::::::::::::::::::::::::::::::::::::::::::::::N:::::::::
NP2518A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
hla0997         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HVO_2349        :::::::::::::::::::::::::::::::::::::::::::::::::T::::::::::
Hbo2033         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       EARAYRALLRTGPTTAKELSRASDVPMGRIYDVLNSLEQYNLVRSQAASRPKKYVAVEPD
#oth            121121311521321122222312111..1..1.111.233.1.1.2111..1.11...3
hla0613         :D::::G::GL:TG::ADVTAE::::K:::::A:GG::SRG:::V:SDRE::R:AP:::A
VNG1903         --------------------------::::::::G:I:SQH::::::::::::::::::E
rrnAC3310       ::::::S::E::::::::::::::::::::::::::::T:::::::T:::::::::::::
Hmu2284         :D::F:S::D::::::::::::::::::::::::::::T:::::::T:::::::AP::::
NP2518A         :::::::::K:::::::::::V::::::::::::::I:::::::::S::::::::::::S
hla0997         :::::::::::::::::D:::::E:::::V:::::::::H::::::::::::::A:::::
HVO_2349        ::::::::::::A::::::::::::::::V::::::::::H:S:::::::::::::::::
Hbo2033         ::::::S:::::A::::::::::::::::::::::::::HS:::::::::::::::::::

consensus       TALDRLLEDKKRELEEKAEQYENVVDELSDELEAAEPVEDQFWTAAVGPDESLDLLLERL
#oth            2.12..1.41211.322241.142112.351.242222324....11.22323..13..2
hla0613         V:V:::V:A:R::::RRI:T::SGK:::I:Q:AD::TTD:R:::::::AED:::::F::V
VNG1903         :::N:::::R::::Q:::T:::::::T:AR::DHPKAP::G::::EL::AAA:::W:::I
rrnAC3310       ::::::::::::::Q::VG:::EI::D::SQ::S:D:::EP:::::::::N:::::::::
Hmu2284         :::E::::::::Q:D:::K:::EI:::::NQ::S:::::EP::::::::A:TV:::V:::
NP2518A         ::::::::::::::D:::N:::SI:::::G:::T::::::T::::::::::TV:::M::I
hla0997         A:::::::E::::::TQ:::::G:::D::T::D:G:::DG::::::::AEDAT::::::I
HVO_2349        ::::::::S:RQ::A::::::::::A::T:::D:::::H:::::::::A::TI:::V:::
Hbo2033         ::::::::T:H::::::::::QA:::D:T::::T::::QG::::::::ME::V:::::::

consensus       AAADDSIVMVAGTPARQ-FDLDRVGERIVDELEAALDRGVDVSVLLSPDLVDSLPESVGE
#oth            2..333323.324334112123542432311.34.33...2122.221443343144223
hla0613         D::A::::V::TEVSS:::EV::E:PVLL:R:LS:IR:::::::::::AMF:DALAAID:
VNG1903         D::Q:T:TL:S::::SG:::::D:SSQVF:R:AV:VE::::::::::S::A:CM:HD:N:
rrnAC3310       :::::E:I::GSA:::::V:ILSGT:::::::::::E:::E::L:VR:::FE::::EANR
Hmu2284         S:::ER::::GSL:G:::L::TEATD:L:::::R::Q:::E:YM::P:SF:EAV:AD:::
NP2518A         S:::SEV:::LSSYIE:F::I:T::TL:L:::TD:M::::::RL:MR:EVMSV::::I::
hla0997         :::ERRM:V:::A::TG::::GTI:::VT:::::::::::EIR:::::AT::A::R:::R
HVO_2349        ::::::L:::::::SP::::::A::DLV:::::::::::::::M:M::G::::::::::Q
Hbo2033         S:::S:L:I::::LSP::::IG::::L:TE::::::::::N::::M:::::A:::KT::K

consensus       RYADRLSDYDNFEVRTTENVTGTFNLIDDVEVCIEVPHPLGPGEAFAMIDLKDREFAADV
#oth            317541666451431343524221422.14..11..12.164334.121.22.32.1332
hla0613         DH:VLAMAQGA:TL:V:DD:Y:N:Y::::E:::L::SD::A:DRL:G:L::R::G::TR:
VNG1903         ::I:A:A:DPTY:::IGDSID:NVTI::GA:::L::SN:VQ::::::T:::Q::::::::
rrnAC3310       E:YE::FH:::YSA:ASP:IRT::E:L:G::::::::::::RE:T:GV::M::SD:T::I
Hmu2284         S:QR::QQ:::YHY::::E::S::E::::I:::::::::::-:ST::V:::::P:::DEI
NP2518A         ::RTS:TENER:T:CIS:D:::::T::::N::T:::::::KNR:V::::::::::::QS:
hla0997         ::TAD:::MEG:::::IAG:D:::SVF:GI::::::::::SAD:P:::::V::A:::TS:
HVO_2349        S:M::::SRS::RA::A:::::V::::::::::::::N::N::Q:::::::::P:::::L
Hbo2033         ::VT::ENHPQ:::::::QLS::::::::::::::::N::D::::::::::::A:::T:I

consensus       RAAFEPRWEEAEPLTL------
#oth            345.224.44153245511111
hla0613         SDG:VDA::S:DVVEEI:::::
VNG1903         :::::ES:GDSTT:G-::::::
rrnAC3310       SQ:::EH:A::K:VGPP:::::
Hmu2284         Y:E:::::QR:REIVGD:::::
NP2518A         :SE::::::Q::E::F::::::
hla0997         KDQ:::Q:G::::::FG:::::
HVO_2349        ::T:D::::::A::P:::::::
Hbo2033         :EM:D:::D:::::::SSFSDD