[K] (-) COG1395 Predicted transcriptional regulator 9 genomes BUD0632 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG2112 rrnAC2519 HVO_0338 Hbo1141 Hmu3016 Hut2494 hla0263 NP1320A HQ3058A

Pairwise sequence scores
Consensus score	2393	VNG2112	hla0263	HQ3058A	HVO_0338	Hbo1141	Hut2494	NP1320A	rrnAC2519	Hmu3016
1503	VNG2112	2064	1384	1335	1393	1396	1303	1364	1497	1432
1975	hla0263	1384	3574	1897	1884	1882	1659	1621	1683	1682
2014	HQ3058A	1335	1897	2434	1932	1982	1693	1671	1730	1736
2056	HVO_0338	1393	1884	1932	2453	1968	1681	1723	1746	1785
1995	Hbo1141	1396	1882	1982	1968	2365	1630	1662	1702	1723
1875	Hut2494	1303	1659	1693	1681	1630	2376	1742	1804	1808
1916	NP1320A	1364	1621	1671	1723	1662	1742	2345	1772	1791
1989	rrnAC2519	1497	1683	1730	1746	1702	1804	1772	2396	2126
2012	Hmu3016	1432	1682	1736	1785	1723	1808	1791	2126	2385

482 symbols
consensus       ------------------------------------------------------------
#oth            111111111111111111111111111111111111111111111111111111111111
VNG2112         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
hla0263         MSATTTPGEVRGSSAAANSRTVSAARSNAASASTPETWSATAALPRVLCFTAGLSRTRSR
HQ3058A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HVO_0338        ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo1141         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hut2494         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP1320A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
rrnAC2519       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hmu3016         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       ------------------------------------------------------------
#oth            111111111111111111111111111111111111111111111111111111111111
VNG2112         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
hla0263         RRTRPPAASSRSASRAPTYVVHIPRSRESVSSTATMGIRALSRSRTNRFRGADGVTADQE
HQ3058A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HVO_0338        ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo1141         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hut2494         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP1320A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
rrnAC2519       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hmu3016         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       ------------------------------------MSRSALVGNITAMLEDAGFLVSDR
#oth            111111111111111111111111111111111222111211221241113112131111
VNG2112         ::::::::::::::::::::::::::::::::::::------------------------
hla0263         IYNCIDTPIRKIASGRAFRAHTADTTHIYGEPLIST:::T::IE:::::::::D::::::
HQ3058A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HVO_0338        :::::::::::::::::::::::::::::::::LPP:::::::::VA:::Q::::V::::
Hbo1141         ::::::::::::::::::::::::::::::::::::------------:::::::V::::
Hut2494         ::::::::::::::::::::::::::::::::::::::::::::::I:::::::::::::
NP1320A         :::::::::::::::::::::::::::::::::::::::::::::::::::::::T::::
rrnAC2519       :::::::::::::::::::::::::::::::::::::::::::E:VM:::::::::::::
Hmu3016         :::::::::::::::::::::::::::::::::::::::::::E:V::::G:::::::::

consensus       CAIRPKSFDIAARRGEDLLLLKILGNIDAFDAETGAEMRRLGEYLDATPLVIGLRTRDEE
#oth            212111111311112213412.1.2.1..1.26..31.....4..5...2.1.2.....1
VNG2112         --------------------M:V:V:::::::::::::::::T::H:::::V:::::::D
hla0263         ::V::::::V::::D:::V:::::::V::L:::::::::::::::Q:::M:::I::::::
HQ3058A         :::::::::V::::::::V:::::::V::L:RM:::::::::G::::::::::V:::::D
HVO_0338        I::::::::L:::::::::::::::::::::GV::S::::::S::::::::V:::::::D
Hbo1141         :::::::::L::::::::T:::V:::::::::A:::A:::::D::S:::::V:::::::D
Hut2494         :::::::::::::::::TI:V::::::::::GL::::::::::::E::::::::::::::
NP1320A         :::::::::::::::D:V::::V:A::::::GY::T::::::::::::::::::::::::
rrnAC2519       :::::::::::::::::V::::::::::::::Q::G::::::T::N:::I::::::::::
Hmu3016         :::::::::V:::::::V::V:::::::::::M:::::::::T::N:::M:V::::::::

consensus       LKPGVVYFRHGVPVLSPDTAMDLFVEEVPPLIYAAPGGLYVNIDGDLLADEREERDWSLG
#oth            .1.1..........31.1.1111.2112...1.........11.112.114.23122...
VNG2112         :D::::::::::::FN:::::E:::DGI:::V::::::::::::::V:::R::DERL:::
hla0263         ::::::::::::::IN:::GY:::::GM:::::::::::::SL::::::::::::G::::
HQ3058A         :::N::::::::::::::::::::::G::::::::::::::::::::::::::::G::::
HVO_0338        :::::::::::::::N:::::::::::::::::::::::::SL:::V::E::Q::G::::
Hbo1141         ::::::::::::::MN::::::::L:G::::::::::::::::::::::::::K:G::::
Hut2494         ::::::::::::::F::N::::Y:::::::::::::::::::::S:I:::A:::::::::
NP1320A         ::::::::::::::F:::::::::I:::::::::::::::::::::::S:I:SQE:M:::
rrnAC2519       ::::::::::::::::::::::::::::::::::::::::::::SEI:::V::D::::::
Hmu3016         ::::::::::::::::::::::::::::::::::::::::::::SEV:::A::D::::::

consensus       RLATELGVSRRTVSKYEDGMNASIEVAAELEELFDEPLSSPVDVLDGAEEVRDAEPTPDD
#oth            2..3.............1..2..111.24.112.342122.13.131112..14232.22
VNG2112         Q::S:::::::::::::::::::::::MR::D::GGE:TA::::M::::D:::TD:::::
hla0263         :::::::::::::::::::::::::::IQ::D::N::F::::::::::G:::::D:::SA
HQ3058A         :::::::::::::::::::::::::I:IQ:::V::::F:::LE:ME:::S:::S::::::
HVO_0338        Q::::::::::::::::N:::::::::IH::::::R:F:N:::::T:::D::::::::::
Hbo1141         :::::::::::::::::::::::::::IH::::::Q:F::::S:::::::::::::::E:
Hut2494         K::N:::::::::::::N::D::V::::T:DD::E:::T:::N::EES:D::EDDSM::E
NP1320A         K::N::::::::::::::::S::V::::::::I::RK:A:::E::S:::::::DVDE:EA
rrnAC2519       :::K::::::::::::::::D::V:::::::D:::A::T:::S::::::::::D::::::
Hmu3016         :::K::::::::::::::::D::VD::::::::::A::T:::S::::::::::E:E::E:

consensus       PEVDPDDEHVVTVLTRAGFEVHPTARAPFKAVSEDEDERR---RVLTGHSAFTRAAEKRA
#oth            .13111.2421211112..2....41....2.2.33455744252.1.1.51132.3...
VNG2112         ::AA:E:VP:LS::A:V:::::::VQ::::::G:AGAGHD::::L::::::::E::V:::
hla0263         ::T:::::::LH:::N:::T::::::::::::::::GSSPA:::::::::T::P::::::
HQ3058A         :DP:A::::::HI::::::T::::::::::::G::D:N::GVMSL:::::S::KS:K:::
HVO_0338        :D::::::::LS:::::::T:::::::::::::::AGRKKET:N::::::P:::S:::::
Hbo1141         :DA:::::::LHI::::::T:::::::::::::::::K:SDQIPM:::::T:N:S:K:::
Hut2494         ::::::::QL::::::V::D::::N:::::T:::::::AEAD::M:::::KLNE::R:::
NP1320A         ::A::::AEI::::::V:::::::MQ::::::::::KRE::::K::::::E:N:T:::::
rrnAC2519       :D:A:E::PI:::F::I:::::::D:::::S:N:SD::HG:::Q::A::::::ET:::::
Hmu3016         :::A:E::SL:::F::I:::::::D:::::T:::N:H::Q:::Q::::R:E::KT:::::

consensus       RIMSSVGEVTRTRSVYVVDE-AKRESVDGTALVECEELAAIDDPDELRDLIRERAEDPEE
#oth            1..1.2.31131.11.1123354.11121.111143.223131233112.121.345342
VNG2112         ::::::::::H::A::::::::G:::::D::I::R::::NV::SED::::LAD:GDLQ:A
hla0263         :::::I:::A::::::FTE:NED::::::::::S:::::D:S::EGI:E:::D::KA:S:
HQ3058A         :::::L::::Q::A::FTETD:::DA:K:::::S:A::D:V:::AAI:::::::SQK:T:
HVO_0338        Q::::L::I:::::::F:E:QQ::::::::GI:S::::::::::::I:::::::TR::A:
Hbo1141         :::::L:Q::Q:::::FTK:QS::D::E:::::S:D::::::::::I::::::::DE:T:
Hut2494         :::A:::R::GA::::::ER::T:::LE::::::ES:MDD:EVAE:::E:::::S:K:A-
NP1320A         :::::::H:::::::::::S:T::D:::::::I:R::FER:H:S:::EN:::::::G---
rrnAC2519       :::::::::::::::::::::LR::::E::::I:K::MEN:E:AID:::::M::G::R::
Hmu3016         ::::::::::::::I::::::L:::::::::II:QS:ME::::A:D:::::M::G:::::

consensus       A-
#oth            31
VNG2112         -:
hla0263         ::
HQ3058A         ::
HVO_0338        S:
Hbo1141         ::
Hut2494         -:
NP1320A         -:
rrnAC2519       VA
Hmu3016         VA