[L] (RFA1) COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins 9 genomes BUD0104 10 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG2160 pNG2007 rrnAC2744 HVO_0292 Hbo1190 Hmu2839 Hut2332 hla0388 NP1282A HQ3263A

Pairwise sequence scores
Consensus score	2310	pNG2007	hla0388	HQ3263A	HVO_0292	Hbo1190	VNG2160	NP1282A	Hut2332	Hmu2839	rrnAC2744
1662	pNG2007	2833	1456	1441	1430	1507	1524	1563	1533	1544	1548
1799	hla0388	1456	2284	1502	1709	1704	1562	1561	1667	1654	1644
1700	HQ3263A	1441	1502	2293	1666	1772	1400	1536	1579	1558	1526
1893	HVO_0292	1430	1709	1666	2303	1951	1568	1581	1645	1668	1676
1934	Hbo1190	1507	1704	1772	1951	2372	1619	1632	1676	1699	1689
1833	VNG2160	1524	1562	1400	1568	1619	3559	1637	1677	1708	1652
1884	NP1282A	1563	1561	1536	1581	1632	1637	2294	1705	1801	1750
1926	Hut2332	1533	1667	1579	1645	1676	1677	1705	2324	1867	1938
1999	Hmu2839	1544	1654	1558	1668	1699	1708	1801	1867	2311	1950
1976	rrnAC2744	1548	1644	1526	1676	1689	1652	1750	1938	1950	2344

475 symbols
consensus       ------------------------------------------------------------
#oth            111111111111111111111111111111111111111111111111111111111111
pNG2007         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
hla0388         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HQ3263A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HVO_0292        ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo1190         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
VNG2160         MTASSPNRARTSLAAYASAGPVSLPAGSTRTVASGTSSRTRSAYASRVTASRSSAKAARS
NP1282A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hut2332         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hmu2839         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
rrnAC2744       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       ------------------------------------------------------------
#oth            111111111111111111111111111111111111111112112212121222222222
pNG2007         :::::::::::::::::::::::::::::::::::::::::MCVHTRKPDGLHPKPVSHC
hla0388         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HQ3263A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HVO_0292        ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo1190         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
VNG2160         AVRRSRLRSSSPSASSCLGRWLRLAGYSRVPVPPASRTAATVCVTARSPGGWSACRRVRR
NP1282A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hut2332         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hmu2839         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
rrnAC2744       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       -------------------------------------------MSDLRTHAAEIHEQFSD
#oth            22222222222222222222222222221221233233233322121333.321211131
pNG2007         PVIDTGQSEWRSFTFTTICMGFRPRQAYRQPSPIANETENTMSN:NIQQE:QD::D:LPE
hla0388         :::::::::::::::::::::::::::::::::::::::::::::E::QE:EA:A:::::
HQ3263A         ::::::::::::::::::::::::::::::::::::::::::::T::Q::::::A::::E
HVO_0292        ::::::::::::::::::::::::::::::::::::::::::::T:::::::::AD::::
Hbo1190         :::::::::::::::::::::::::::::::::MKTKVEASET:::::::::::A:::::
VNG2160         RGPNACLRGASDRVHPGCGDLKGVGSKHRYVSHRNTRGDGYTT::::SDT:Q:V:DDL:E
NP1282A         ::::::::::::::::::::::::::::::::::::::::::::::::E::T::::::::
Hut2332         ::::::::::::::::::::::::::::::::::::::::::::T::H:::E::::::A:
Hmu2839         ::::::::::::::::::::::::::::::::::::::::::::T::H:P:T::Q:::D:
rrnAC2744       :::::::::::::::::::::::::::::::::::::::::MTE:::::::T::::::::

consensus       HLDVSVDDVEERLETLVNEYRVPVDEARRSVVNSYLDEAGIDRDELGG--GGGNEQVDLA
#oth            42133322233..43..41.3..32..1...312.1211131.12222113221243633
pNG2007         SV:A:PE:I::::T:::DD::::L:::Q::::ST::SDSDV:::DVSS::ENE:Q::::E
hla0388         ::::GA:E::::::N::::::::L:::::::T::::ED::ME:::::-::R::S:S:LVN
HQ3263A         E::IDETT:RD::N:::E::S::A:::::::I:::::::D::::::S:::SD:::EIP::
HVO_0292        :::::A:E::::::S::T:::::::::::::::::::::::E::::A:G:S:::::TL:N
Hbo1190         ::::DA:::::::QN::D:::::::::::::::::::::DLE:::::-::R:::DE:H::
VNG2160         :V:AT:::::A:::K::S::K::::::::::E:H::::::L:::D:A:::::::DT:EVE
NP1282A         AI:E:::ET:S::::::S::Q:::E:::::::ST:I::SD::::::S-::::SSQSAEVT
Hut2332         Q::::::::T:::D::::::Q::IS::::::T::::::::L::EDI::G:S::::T:QA:
Hmu2839         Q:::T::EI::::::::E::K::LS::::::::T:::D::M:::Q:S::::::::H::I:
rrnAC2744       Q:EID::::I:::D::::D:Q::IS::::::::T::::::M:::Q:::GD:::::::NV:

consensus       DIDEDEQWVDVTAKVVELWEPRSDSIAQVGLLGDETGTIKFTKWSKSDLPELEEGQVYRL
#oth            21122.1.2.3112111..11321112....1..21.13..12141.1.1313.133.3.
pNG2007         E:T:A:::::I::::AD:::::::::::::::::::::::::::A::::EA:T:::::::
hla0388         E:::::::::LRVEL:D:::::::::S::::::::S:::::VAFET::::::T:::A:E:
HQ3263A         S:::::::I::::::::::::QNEA::::::I:::S:RT::VAFET::::AI:::A::E:
HVO_0292        :::::::::::R:::::::::::E::::::::::DS:RM::VSFTT:E:::::::KS:A:
Hbo1190         :::Q::::::I::::::::::::E::S::::::::S:RM::VSFTT:E:::::::A::::
VNG2160         :V::A:::::I::::::::::::::VG:::::::P:::::::::A::::ET:D:::::::
NP1282A         :::AP:E:L:L:V:::D::::GA:::::::::::::::V:::::Q:::::A:::DE::::
Hut2332         :V:AP:E:::M:::::::::::::AV::::::::::::::::::::::::::A::AT:H:
Hmu2839         :V:AP:E:I::::::::::DATA:AV::::::::::::::::::::::::::::::::E:
rrnAC2744       :V:AP:E::::R:T::::::::A:AV::::::::::::::::::::::::S::::KS:A:

consensus       GNVVTDEYQGRFSVKLNRTTSIEELDEEIEVGDDATEVEGALVDIQSGSGLIKRCPEEDC
#oth            3.......1.41.....2..5.133.2211...233332...1.2...........221.
pNG2007         ::::::::::QY::::::::T::A::QD::::::T:DA:::::::::::::::::::D::
hla0388         S:::::::E:SY::::::::Q:T:I::::::::N:DT:::::::::::::::::::::::
HQ3263A         E:::::::::DY::::::::D::K::TD:T:::S::TI::::I:::::::::::::TDG:
HVO_0292        ::::::::::N:::::::::::T:::::::::::S:S:::::::S:::::::::::::G:
Hbo1190         ::::::::::N:::::::::::::::::::::::S:T:::::::::::::::::::::G:
VNG2160         :::::::::::Y:::::K:::::AV:::F::::NED::A:::::V:::::::::::::::
NP1282A         E::::::::::::::::S::N::R::TD::::::T::T::::::::::::::::::KP::
Hut2332         R:::::::::::::::::::V:::T::::::::::L:::::::::::::::::::::D::
Hmu2839         R:::::::::::::::::::T::AV::::::::::V::::::::::::::::::::::::
rrnAC2744       R:::::::::::::::::::T::::::A::::::SV:AD::::::::::::::::::D::

consensus       TRVLQNGRCSEHGEVEGEFDLRIKGVLDDGEEVTEVIFDREATEELTGITLEEAKQMAMD
#oth            .........1...411........1.2.1.23.2....3311..412124.31112..2.
pNG2007         ::::::::::::::G:::::::::::I:N:DT:Q:::::K::::QVAD:::AQ:QE::::
hla0388         :::::::::::::Q:::::::::::::::::T::::::::::::::::MG:::::D::::
HQ3263A         :::::::::::::T:D::::::::::I::::T::::::T::M::K:S::::S::Q:::R:
HVO_0292        :::::::::::::S::::::::::A:V:::D::H::::N::M:::::::E:D::::::::
Hbo1190         :::::::::N:::N::::::::::::::::DN:H::::G::M:::::::S::::QE::::
VNG2160         :::::::::N::::GD::::::::::::::TD:H:::::E::::A::::G::::::::K:
NP1282A         ::::::::::::::::::::::::::::::T::::::::K::::::::::::::Q:::::
Hut2332         :::::::::::::::::::::::::::::::::::::::Q::::N:::V::::::D::::
Hmu2839         :::::::::N:::::::::::::::::::::::::::::E::::K::::S:::G:E::::
rrnAC2744       :::::::::::::::::::::::::::::::::::::::ED::::::::A:::::E::::

consensus       ALDTTVVADEMRQDILGRYYRVTGPTLGRYVLANETERLTGPVDAEAVLIKARSI
#oth            ....21.21.125333.5...14..11...1.11251515433.3145..3...1
pNG2007         ::::S:::::I:EVT:::::::Q::E::::L:V::F:Q:AEMH:P:QL::T::::
hla0388         ::::::::E::GD:V:::::::::::F:::::VD:M:D-P:A::V:NA::E::::
HQ3263A         ::::S::VE:I:::LI:A:::IS::E::::L::DTVDH::N:A:P::::::::::
HVO_0292        :::::I:EE:::G:LV:Y:::::::::::::::::V:::RE:A:::EL::::::M
Hbo1190         :::::::V::::T:LV:M::::S::E:::::::D::D::NE:A::::::::::::
VNG2160         ::::::::::::AT:::K::::::::F:::::::D::L::TRP:T:S:::R::::
NP1282A         ::::E::VE:::EVV::Q::::::::::::::::D::::D::::::S::::::::
Hut2332         ::::S::VE::QGT:M::::::E:::F:::L::D:I:T::DA::P::T:::::::
Hmu2839         :::::::::::::KV::::::::::::::::::::Q:::D:::::::M:::::::
rrnAC2744       :::::::::::::K::::::::R:::F:::L::D:Q:::::A:::DEI:::::::