[J] (TRM1) COG1867 N2,N2-dimethylguanosine tRNA methyltransferase 9 genomes BUD0694 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG2088 rrnAC2788 HVO_0236 Hbo1262 Hmu3149 Hut2231 hla0918 NP0194A HQ3646A

Pairwise sequence scores
Consensus score	2874	NP0194A	hla0918	HQ3646A	HVO_0236	Hbo1262	VNG2088	Hut2231	rrnAC2788	Hmu3149
1946	NP0194A	2849	1709	1560	1568	1645	1624	1725	1733	1741
2203	hla0918	1709	3334	1838	1906	2019	1799	1687	1798	1747
2068	HQ3646A	1560	1838	2967	1928	2122	1790	1588	1702	1693
2129	HVO_0236	1568	1906	1928	2898	2184	1729	1525	1684	1719
2260	Hbo1262	1645	2019	2122	2184	2888	1805	1637	1738	1781
2049	VNG2088	1624	1799	1790	1729	1805	2836	1643	1694	1781
1987	Hut2231	1725	1687	1588	1525	1637	1643	2857	1887	1903
2170	rrnAC2788	1733	1798	1702	1684	1738	1694	1887	2859	2210
2225	Hmu3149	1741	1747	1693	1719	1781	1781	1903	2210	2876

450 symbols
consensus       ----------------------------------------------------MRVSEGGV
#oth            1111111111111111111111111111111111111111111111111111.423..42
NP0194A         :::::::::::::::::::::::::::::::::::::::::::::::::::::E::::S:
hla0918         MLARRLHVVVISILLFPLRRAKVPASRPHRSRDRSARHAERGPFVVDSRTRG:DIE:::L
HQ3646A         :::::::::::::::::::::::::::::::::::::::::::::::::::::NIT::V:
HVO_0236        :::::::::::::::::::::::::::::::::::::::::::::::::::::H::::::
Hbo1262         :::::::::::::::::::::::::::::::::::::::::::::::::::::D:R:::I
VNG2088         :::::::::::::::::::::::::::::::::::::::::::::::::::::D::::::
Hut2231         ::::::::::::::::::::::::::::::::::::::::::::::::::::::ER::R:
rrnAC2788       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::R:
Hmu3149         :::::::::::::::::::::::::::::::::::::::::::::::::::::::T::Q:

consensus       TVEVPEARDGAS-GKG--DDVFFNPTQELNRDITVAALRAYREREPR-----AESYLDAM
#oth            122..42332122.5.1133..1.11......2.2.2111221143211111233....1
NP0194A         ::::::E:H:::E:S:::EG::Y::V::::::::A:V::TVSDD---:::::CDE:::::
hla0918         ::S:::::::::E:T:::GG::::::::::::V:::V:::::D::::::::::S::::::
HQ3646A         ELT::A:::::DA:V:::::::Y::::::::::::::::::Q::::::::::::T:::::
HVO_0236        EI:::D::::::A:T:::::::Y:::::::::::A:V:::F:::::::::::::::::::
Hbo1262         E::::G::::::E:A:::::::Y:::::::::V:::T:::::::DD::::::::::::::
VNG2088         ::S::T:SG:--::E:AA::::::A:::::::L:::T:A:F::::::::::::A::::::
Hut2231         ::T:::QAEE--::V:::ES:::::V::::::L::::I::V:::VAERDGHPV:T::::T
rrnAC2788       ::T:::QPEA--::::::A::::::V::::::::::::::::::T:::::::VST::::T
Hmu3149         ::::::QA:A--::::::EN:::::V::::::L:I:T:::V:::::::::::::R::::T

consensus       AASGIRGVRAAAEGYDVTCADVDPDAVELARRNLERNDLDGEVVHRDANALMH-------
#oth            1.1.1.1....241212.32.2.32.111243..23122313233211.23112211111
NP0194A         ::::::S:::::A:::::AC:I:D:::A:T::::D::GV::T:H::NV::H:::::::::
hla0918         ::::::::::::::::T:::::::::::::AE::AA::::::T::::V:::LY:::::::
HQ3646A         T:::V:::::::S::::::T:I:::::A::QS:::K:::::QTLPS::::VL:QSGPESP
HVO_0236        :::::::::::::::::::::L:A::::::QS::D:AGNG::A:::N:::::Y:::::::
Hbo1262         ::::::::::::::F::::::L:ES::::::::::::E::::A:::N:::::Y:::::::
VNG2088         T::::::::::NA:W:::M::::A::::::TS::A::G::::::A::::S:L:DH:::::
Hut2231         ::T:V::::::EN:F:A:LC:::EA:::RC:E::AG:::::::L::::::V:::::::::
rrnAC2788       ::::::::::::NDWET:LC:I:D::TA:CEQ:::::::AAS:RRS:::V::::::::::
Hmu3149         ::::V:::::::D:WEA:LC:::::::A:CE::::::G:S:T:R:E:::VA:::::::::

consensus       ---ERVFDVVDLDPFGTPIPFADAAFANARNLVCVTATDTAPLCGAHFESGVRKYSAVPR
#oth            1112543.1..2..1.1.11.1.11222124211.....1.......23..1.2.223.1
NP0194A         ::::SAH:::::::::::MA:::::VRS:GEYL::::::::::::::::::::S:D::::
hla0918         ::::N:::::::::Y::::::::::L:::::::::::::::::::::LN::I:::G::::
HQ3646A         LGP:AI:::::::::::::::::::::::::::::::::::::::::QQ::I:T::TL::
HVO_0236        :::DE:::::::::::::M::::PT:::T:D::::::::::::::::QK::I:::GCL:Q
Hbo1262         :::DS:::I:::::::::::::::::::T:D::::::::::::::::QK::I::::TL:Q
VNG2088         :::D::L::::I::::S:M::::::::::::::::::::::::::::::::::::::T::
Hut2231         :::::Q::I::::::::::::V:::LQS:GRMLA:::::L:::::::::::::S::::::
rrnAC2788       :::SEA:::::V:::::::::::::VQGTKH:L::::::::::::::::::::S:G::::
Hmu3149         :::SDPW::::I::::::::::::::QGT:D::::::::::::::::::::::S:::I::

consensus       NTEYHAEMGLRVLLSALVRTAARYDIAARPILSHVTRHYARTYLELDHGATVADALIEEL
#oth            ..21.2...2.2.11112.....1.3114.211.113..1.1..22151.34.1222342
NP0194A         :::F:::::::::::::::::::H::::E:V:::::S::V::::RV:S::RA::::L:H:
hla0918         ::D::P:::::T:I:::::::::::K:::::V:::S::::::::::ES::Q:::DC:D::
HQ3646A         :::::P:::::::::::I:::::::T::I::::::::::V:::::::TR::R::E:LSD:
HVO_0236        ::D::P:::::T::G:M::::::::K::V:::::A::::::A:::::ER::K::E:L:ST
Hbo1262         ::D::P::::::::::MI:::::::K::V::::::::::::::::::GR::K::E:V:Q:
VNG2088         ::N::::::::I::G::A:::::::VGVT::::::SD::V::::::::R::D:N:AV:QV
Hut2231         :::::S:::A:I::GS::::::::::::::A:T:A:D::V::::D:ER::RA::DA:G::
rrnAC2788       :::F:::::M::::::M:::::::::::::::::A:K::::::::F::::K::NDC:D::
Hmu3149         :::::::::M:I::G:M::::::::V::::::::A:K::::::::::::::::N:AVD::

consensus       GYVYHCQDCLWRDHERGLIADPPDACPNCGQHRLLTAGPLWLGPACDPDFARAVREQITE
#oth            .2121.13..5.3225122121344.25.2342332...21..434243.353.334233
NP0194A         ::ID:::R:::::::::RVP::TTT::H:::S-TW::::V:::::H:AA:VDD:AGA:PD
hla0918         ::IDN:E::::::PTH::::::V:T::V::SD:V::::::::::VA::::::::::RV:D
HQ3646A         ::::::E:::T:Q::F:H::H::SM:HH:EGN:VI:::::Y::SIREQG:T:R::NH::T
HVO_0236        :F::::E:::H:EA::S:V:H::E::A::DST:I:E:::I::::VSE:A::G:::DEV::
Hbo1262         ::::::E:::E::::F::::H:::D::A::SS:T:V::::Y:::V:::::T:R::DH:::
VNG2088         :H:::::Q::S::::Y::V:A:RAE::R::G:QV:::::::::::HEEA::AS::::L:R
Hut2231         :::H:::Q::Y:EA:N::::H::E:::K::::-:Q::::::::A:HKT::LER::G::DD
rrnAC2788       :::H:::H::::::DY:::::::ED::V:EK:-:Q::::I:::RT:::E:VS::S::VS:
Hmu3149         :H:::::Q::Y:S::A::H::A::::::::::-:Q::::::::GT:E::::A::T:HL::

consensus       EMGTAKRARELLATLAAELDTPTHYDQHRLCKRWGRSAIAMDDFLDALRDAGYEASRTHY
#oth            31.12331442.61226.1341..1...1.215.322153.22.225.14..331121.1
NP0194A         SF:::DK::D::S:V:T::HQ:::::::K:Y:::NEPN:::::::A:::A::H:::::::
hla0918         D::E:::::K::G:V:R:::::::::::::Y:A::EP::G::E:V:R::G:::::::A::
HQ3646A         :::EI:Q:DSI:KMVEN::E::::::::::::K:T::::G::E:IEQ:HT::FD:T::::
HVO_0236        DF:::::::K::D:::V:::::::F:::::::L:::::SK:ET::ET::::::D:TPA::
Hbo1262         :::EK::::SM:E:V:G:::R:::::::::::M:S:::TS:::::AE::::::::TQA::
VNG2088         :::E:SQ:FH::Q:IEG::HE:::::::::YSQ::EP:VG:AE:::Q:::::LR:::::F
Hut2231         G::::EEG::::E:::D:::VA::::::::T::::E::V::A:::::::E::H:::::::
rrnAC2788       :::::DE:K::::::G::I:::::::::::::::::G:E:::E:IEK::::::A::::::
Hmu3149         D::::D::A::::::G:::P:::::::::::::::VG:P::::::::::A::H:S:::::

consensus       GGTTFKTDADVAEIRAATAD-D--------
#oth            3..11.131325121412435343111111
NP0194A         ::::::::::::D::N:VE-:-::::::::
hla0918         R::AV:ST:SIP:M:D:ILGNEGDADGDAD
HQ3646A         S::A:::N:TI::::S::T:P:EQ::::::
HVO_0236        H::A:::::T:::::EV::AL:PEA:::::
Hbo1262         S::A:::N:TIE:M::V:T:S:N:::::::
VNG2088         ::::::::GGL::VE::VL-:-::::::::
Hut2231         :::::::T:::S:::::::GDE::::::::
rrnAC2788       :::::::::::V:::E:::::-::::::::
Hmu3149         :::::::A:::T:::D::V:SS::::::::