[H] (CbiG) COG2073 Cobalamin biosynthesis protein CbiG 8 genomes BUD0950 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG1554 rrnAC3003 HVO_B0059 Hbo1624 Hmu1994 - hla2067 NP1118A HQ1831A HQ3035A

Pairwise sequence scores
Consensus score	2428	HQ3035A	HQ1831A	rrnAC3003	NP1118A	HVO_B0059	Hbo1624	VNG1554	Hmu1994	hla2067
775	HQ3035A	2333	549	729	716	687	707	689	704	745
1772	HQ1831A	549	2446	1578	1555	1753	1730	1648	1642	1682
1981	rrnAC3003	729	1578	2451	1742	1856	1862	1943	1862	1866
2017	NP1118A	716	1555	1742	2409	1925	1909	1876	1913	1859
2191	HVO_B0059	687	1753	1856	1925	2474	2308	1930	1949	1913
2157	Hbo1624	707	1730	1862	1909	2308	2425	1897	1928	1934
2107	VNG1554	689	1648	1943	1876	1930	1897	2429	1938	1974
2076	Hmu1994	704	1642	1862	1913	1949	1928	1938	2456	2020
2078	hla2067	745	1682	1866	1859	1913	1934	1974	2020	2508

346 symbols
consensus       MS-----------DNDSTNDSSGGH-CSTPDSDGEVAEEIAIVSFERKLDTAEEIRAELA
#oth            112321111111124534322321211311111.11143.11111.11421.43143313
HQ3035A         --:::::::::::--MN::T::VST:ATAASDG:RSINS:G:::::::W:::TT:::T:T
HQ1831A         ::::::::::::::TEN::EETS::::::::::::::T:::VIAP:HAD:::DN:QTT::
rrnAC3003       --:::::::::::MSTD:D:D::S:G:KA:::::::::N::::A::::M::::D:VDGIG
NP1118A         --:::::::::::-MSD::::D::S:::::::::::::::G:::::::RPV::::::::S
HVO_B0059       ::DT::::::::::TN:DT::GS::::Q:::::::::D:::::::::::::::::KRD::
Hbo1624         --:::::::::::--M:DS::GS::::::::::::::R:::::::::::E:::::KRD::
VNG1554         ::T:::::::::::::TET:D:::::::::::::::::D::::A::::R:::A::V:GIG
Hmu1994         ::TETD::::::::::TG:EE:S:::::::::::::::::::I:::::::::R::E::IG
hla2067         ::TDDDTTTDASS:ST:S::D:::::::::::::::::::::I:::::WE:::DVE::::

consensus       DDYDRIDILEYHGDVFAEHWGEYDCFVGLMASGIAMRKTAGLLDDKWED-PAVVVVDEEL
#oth            231221.222.2211.132..2...121111.1111111.3..1.112111111.2.12.
HQ3035A         EEFSTV:LI::D::::ER:::::::LL:::::::V:::S:N::A:ASAPSQPI::T::::
HQ1831A         SA:::::LI:::T:A::D:::V::::I:VLP:DTVTQQ::P::::::D:::::::I:SN:
rrnAC3003       :R:ES:::::::::::E:Y:::::::I:::::::::::::H::::::D::::IC::::::
NP1118A         :::E:::::D:::E:::DN::D:::::::::::::::::::::::::::::::::I::::
HVO_B0059       :::::::V:T:::::::D::::::::::::::::::::::::::::::::::::::::::
Hbo1624         :::::::::T::::::::::::::::::::::::::::::::::::::::::::::::::
VNG1554         :R::S::::D::::::::::::::::::::::::::::::::::::::::::::::::A:
Hmu1994         :::ESV::V:::::::E:Y:::::::::::::::::::::P::::::D::::I::I::A:
hla2067         :R:SS::LI::ES:::EQ::::::::LA::::::V:::::::::::::::::::::::A:

consensus       TWAIPITGGHHGANQVADDLAKLGAVPAMTTASEAAGKQGVESKAKALDSHVVNGDSTVA
#oth            .....11..11......41.341.....1.11.1112111114211..22..2112111.
HQ3035A         ::::::L::ED::::::TA:EQM:::::V:SG:VTNRN---DAQST::K:::DSETEMT:
HQ1831A         ::::::::::::::::::::TA::::::::::::::::::::TR::::N:::I::K::::
rrnAC3003       :::::::::::::::::::::SM:::::::::::::D:::::KQ:::::A::::::::::
NP1118A         :::::L:::::::::::H::S:::::::::::::::::::::::::::::::::::::::
HVO_B0059       :::::L:::::::::::H::S:::::::::::::::::::::::::::::::::::::::
Hbo1624         :::::L:::::::::::Y::S::::::::::::::::::::::::::::T::::::::::
VNG1554         :::::L:::::::::::::::SM:::::::::::::::::::ER:::::T::::::::::
Hmu1994         :::::::::::::::::N:::R:::::::::::::::::::::::::::T::::::::::
hla2067         :::::::::::::::::::::SM:::::::::::::::::::::::::::::::::::::

consensus       TNLAVLNDELGPVARLDGPKAVLVGDDVTVLKRNGDDGVVLGTGSVSGADKEQFLDAWEA
#oth            .1.111214131121211.41.2111211.121.431111..21212113431242..33
HQ3035A         :Q:DIRA:ASSII:P-E::AV:::D:ETA:TTT:TTTAI-::VAAADT:TP:IIDT::TT
HQ1831A         ::::::DET:D::S:I:D:T::IADQS::::N:::N::I:::::::::::TS:::T:::R
rrnAC3003       ::::::D:::::IE::::::::::D:::::::::K:::I:::C:::A:::V:::HA:::Q
NP1118A         :::::::::::::E:::::R::::::::::::::S:::::::::T:D:VR:::V::::::
HVO_B0059       :::::::::::::::::::::::::::::::::::G:::::::::::::K:A:::T:::Q
Hbo1624         ::::::::::::::::::::::::D::::::::::::::::::::::::K:::::T:::R
VNG1554         ::::::DEN::::::::::Q::V:::::::::::S:::::::::::::::EQ::R:::A:
Hmu1994         :::::::E::A:::::::::::::::::::::::E:::::::::T:::V:TQ:V::::D:
hla2067         ::::::D:G:::::::::::::::::::::::::::::::::::T:::V:T::VV:::DR

consensus       ALDDAD-CDIDDVDFVATGTRKADEDGLLAAAEEIGLGVVAFEKETLEEFEGPTPSRSKE
#oth            2.435214131..211..211123131123..324221.241211214521112111211
HQ3035A         I:A:H:TVT::::AVI::---LDPT:A:TT::K:M::A:ACVDADPPAVDADAVTDAEVA
HQ1831A         ::STVE::TW:::::I::::::ET:P::::::NDVNV::IS:C::::F::::::::::::
rrnAC3003       :::E:::L:R:::E:::::::::::E:M::::::W::::I::::::::G:::::::::::
NP1118A         ::GETE:H::S::E::::A:::EG:A::YE::::::V:::C:D::::LDH:::S:::A::
HVO_B0059       :::::::::W:::::::::::::::P:M:D::::::A:::Y::::::T::::::::::::
Hbo1624         :::::::::W:::::::::::::::P:M:D::Q::DA:::Y::::::T::::::::::::
VNG1554         S:AAT::Y:::::E:::::::::::E:::::::AL:::::::::::::AH::::::::::
Hmu1994         ::::L::L:RS:::::::::::EG::::YE::Q:::A:::L:::::::T::::S::::::
hla2067         ::TAEG:L:F:::::::::::::G::::YE::Q:LD::::L::::D::::::::::::::

consensus       LIGWPGIAEASAIAGGRDHELLAEKERY--DEAVTVAVGR------
#oth            11111111.11111112322143.142211.2.....213111111
HQ3035A         VTQLDTSI:SITTTAMTTTTATS:TQTMNG:T:::::LAIISEDAQ
HQ1831A         :::::::::::::::::N::::V::LK::::::::::::Q::::::
rrnAC3003       ::::::::::::::A:SE:D:::::T:::::::::::I::::::::
NP1118A         ::::::::::::::::::::::R::::F:::::::::I:K::::::
HVO_B0059       :::::::::::::::::::::VV::R:::::D::::::::::::::
Hbo1624         :::::::::::::::::::::IV::Q:::::D::::::::::::::
VNG1554         ::::::::::::::::::N::::::::::::::::::::K::::::
Hmu1994         :::::::::::::::::E:D:AR::::F:::D::::::::::::::
hla2067         ::::::::::::::::::::::::::::::::::::::::::::::