[R] (-) COG2159 Predicted metal-dependent hydrolase of the TIM-barrel fold 7 genomes BUD1161 7 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG0297 rrnAC1814 HVO_0775 Hbo0755 Hmu0659 Hut0557 hla2534 - -

Pairwise sequence scores
Consensus score	2079	VNG0297	hla2534	HVO_0775	Hbo0755	Hut0557	rrnAC1814	Hmu0659
1451	VNG0297	2079	1200	1299	1261	1187	1271	1228
1459	hla2534	1200	2105	1357	1375	1190	1276	1213
1604	HVO_0775	1299	1357	2071	1606	1265	1347	1206
1611	Hbo0755	1261	1375	1606	2106	1287	1310	1250
1583	Hut0557	1187	1190	1265	1287	2053	1443	1456
1668	rrnAC1814	1271	1276	1347	1310	1443	2074	1582
1574	Hmu0659	1228	1213	1206	1250	1456	1582	2079

277 symbols
consensus       MLELEHGFRVVDVHARLDPDAERR--PRGREISPERLEREMHQAGVVRAVVSPGAR--EG
#oth            ..1.1.1..1..3211.21244331132214132.21...11...1.1111212414433
VNG0297         ::::::::::::C::::HAGPG:P::S:::T:EG:AF::::::::I:::::F::P:KG:Q
hla2534         ::G:::D::I::TR:T::::-:SSVATH::D::::::::::L::::::::::::R:AAGR
HVO_0775        :::::::::::::N::::::-::SVAV:::::::::::::L::::::::::::::QRVA:
Hbo0755         ::::N:::::::L:::::::S:EAVAT::::::A::::::L::::::C::::::R:TEGE
Hut0557         ::::::::::::T:V::E:E:DQ:::SGDGPGT::::::::::::I::SL:Y:S::::::
rrnAC1814       :::::::::::::::::E::KH::::::DGMGD::Q::::::::::::S::F::E:::D:
Hmu0659         :::::::::::::::::E:E:S::::::EGMGD:::::::::::::::::TYSDY::::R

consensus       SYLRANNAVARMSVDRPFVAFARINGPRDPGGGAGARLRNLTASRDDDHTDPEDIEQYAY
#oth            1..11...1..2213..11.1..22.1...34123121..3221.414114.211..11.
VNG0297         G::::::::::EA:K:::::::::D::::::R::V:AV::VA:::::WQ:T:::::::::
hla2534         :::::::::::L:I:::::::::L::::::RN:PLSAV:::R:E:E:H:AR:D:V:::S:
HVO_0775        ::::P:::::::::::::L:::::::::::S:R:S:::::FRS::A:H:A::D:::::::
Hbo0755         G:::::::::::::::::::::::::::::S:R:S:::::::T:::ES:A::::::::::
Hut0557         :::K::::I:::::G:::::L::LS:::::DS:T:::::::::::NE:::A:GE:::F::
rrnAC1814       :::K::::::::T:E::M:::::V::A::::S:P:ST::::AS::T::::S:::::::::
Hmu0659         G::K::::::::T:G::M:::::VD:A::::A:::S::::I::::EEY::S:::::::::

consensus       DDRFHGFKLHPAVDGLPDEDVLDALEAVGLPVLVHGGEAFPPEAVAETLLDRDFPVILAH
#oth            ....2..2.3.25....1221135.23121.32.22.23.4.413223114223.21222
VNG0297         :::::::::D::Q:::::A::::V:DD:::::::D::RQ:T:A:L:::::::E:::V:G:
hla2534         :::::::T:V:HA::::N::::TR:::AD::LI::A:RQ::::::ERE:::Y:M:IV::S
HVO_0775        :::::::S:A::::::::DET:AM::D:::::F:E::Q::E:S:::QS::G:-:::::SG
Hbo0755         :::::::T:A:::::::::ET::Q::N::::T:::V::::T:DDAV:::::::::::F:G
Hut0557         ::::V:::::::K::::::A:I::::S:::::::::::E:G:K:IER::ATA:V:T:V::
rrnAC1814       ::::Y::::::PT:::::::::AE::S:S:::I:::::G:R::::::S::AY::::::S:
Hmu0659         ::::V:::::::R::::::A::E::A::DK:I::::::E:::S::E:HF:QY:L:::VG:

consensus       FGGHPLDRDLMDRAIDLLEAYDDLYLDTSAVRYREPLERALLEHPDRVLFGSGAPEVHPN
#oth            ..12..2221.42221..341141.11.13..1.321..122.....13....1.52..1
VNG0297         ::::::::E::TA:VE:::SHES::V::AG:::::I::::IR::::::V::::::AT:::
hla2534         :::Y:::T:::NETL:::AE::R::V:::::::::V:::GV::::::::::::::D::::
HVO_0775        :::F::::G:::E:::::DDHE:::::::F::::SV::::::::::::::::::::T:::
Hbo0755         :::Y::N::::H:S::::DE:::::V:::Y::F:GVM:::::::::::M:::::::A:::
Hut0557         :::Y::::ER:::T::::G::::::::::F::F::::::::R:::::I:::::::SA::S
rrnAC1814       ::A:::RK:::E:::::::TH:N:::::::::::G:M:::V::::::::::::V:G::::
Hmu0659         ::A:::R::::HES::::::::QC::E:::::::D:::::IM::::::C::::::N::::

consensus       VAVMEILTLDVPEDAMRKVFSNNPARVIEALAPG---
#oth            .22..2.....2..11211122.23.22411121221
VNG0297         :SL::V:::::T::::A::LGQ:L::ILP:A:S::::
hla2534         :G:::V:::::S::L::R::TK::::L:P:::E:ADV
HVO_0775        :G:::::::::S:::LA:A::K:A::::A::G::EQ:
Hbo0755         :G:::L:::::S:::::RA::K:A:::VTE:G::EQ:
Hut0557         ::I:::::::::::::::A:::::G:::D::::-:::
rrnAC1814       ::::::::::::::::::::::::N::::::::-:::
Hmu0659         ::::::::::::::::K:::::::V::::E:::-:::