[S] (-) COG2210 Uncharacterized conserved protein 7 genomes BUD1176 10 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG5059 VNG5238 VNG6057 VNG6469 rrnB0284 HVO_1367 Hbo3420 Hmu3300 - hla0860 NP0976A -

Pairwise sequence scores
Consensus score	1410	HVO_1367	hla0860	NP0976A	rrnB0284	Hbo3420	VNG5059	VNG5238	VNG6057	VNG6469	Hmu3300
991	HVO_1367	1432	1002	965	1017	972	987	987	987	987	1020
1100	hla0860	1002	1463	1195	1023	1054	1096	1096	1096	1096	1085
1068	NP0976A	965	1195	1503	985	994	1064	1064	1064	1064	1064
1087	rrnB0284	1017	1023	985	1427	1005	1083	1083	1083	1083	1037
1170	Hbo3420	972	1054	994	1005	1465	1166	1166	1166	1166	1186
1406	VNG5059	987	1096	1064	1083	1166	1410	1410	1410	1410	1293
1406	VNG5238	987	1096	1064	1083	1166	1410	1410	1410	1410	1293
1406	VNG6057	987	1096	1064	1083	1166	1410	1410	1410	1410	1293
1406	VNG6469	987	1096	1064	1083	1166	1410	1410	1410	1410	1293
1297	Hmu3300	1020	1085	1064	1037	1186	1293	1293	1293	1293	1413

203 symbols
consensus       MSTDTPDAS--------VDDA--PSRAELAARVNELEDALAE--ATSEDDA-KKMSIIAT
#oth            ..21122451111111143352232221.2.1142.133112224341113231.2.11.
HVO_1367        ::S:ADAPV::::::::DAG:::A:VED:R:Q:QA:QQEVSDLREATD::GQ:S:T::::
hla0860         ::A:::AST::::::::N::LDPEAV:D:Q::IDA::TEVSDLRTDVD::GPQ::V::::
NP0976A         :::E::ADAEPSEEPNDGTAVSPEAV:::Q::IDD::TE::DLR:ER:A:S:D::V::::
rrnB0284        ::::::S:G::::::::DG:S::MTE:::Q::IE:::ETV:D::LEAD:EQ::::T:V::
Hbo3420         :::::TSTP::::::::AG:GDQ:::S::::::A::::R::AVESDTD::GPP:::::::
VNG5059         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::S:
VNG5238         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::S:
VNG6057         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::S:
VNG6469         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::S:
Hmu3300         ::::::::P::::::::G:ET::::::::::::D::::E:::::::::::G:::::::::

consensus       KGTLDMAYPPLILASTAAAFGYEVTVFHTFWGLEILHEERSKNLKLSSVGNPNMPVPNAV
#oth            1.11.................11.11.......1.1..12.11.1..1....1..1..12
HVO_1367        :::::::::::::::::::::WD:V::::::::D::::KK:::::::A::::S::M::::
hla0860         ::::::::::::::::::::::D::I:::::::::::::N::::Q:::::::::::::MI
NP0976A         ::::::::::::::::::::::D::::::::::D:V:::N:::::::::::::::::::I
rrnB0284        Q:SF:::::::::::::::::WD:V::::::::D:::::K:E::Q::A:::::::M:::L
Hbo3420         :::::::::::::::::::::::::::::::::D::::::::D::::::::::::M:::L
VNG5059         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
VNG5238         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
VNG6057         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
VNG6469         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hmu3300         ::::::::::::::::::::::::::::::::::::::::::D:::::::::::::::::

consensus       AALPGMDRVTTKMMEKKIDDNDTATIEELIETSLDMGVEFQACQMTIDLMDYDEDDFYDG
#oth            1...1..121.3..221.42.11.111..121..13..11.......1.11...21.111
HVO_1367        ::::F::S:A:S::::::QK:G:::V::::::::::::DL:::::::E::G:::AE::::
hla0860         ::::::::M::R::RN::::::V::V::::::::AS:::L:::::::::LG:::::::::
NP0976A         ::::::::M::R::RG::EA::V::V:::VR::::S::DL:::::::::LG:::::::::
rrnB0284        ::::::::MA:R::::R::::G::::D::::L:::Q:::L:::::::E:::::::::::D
Hbo3420         G:::::::L::E::K:R:R:::::S:::::Q::::L::::::::::::::G::::::FS:
VNG5059         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
VNG5238         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
VNG6057         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
VNG6469         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hmu3300         ::::::::::::::::R:A::::::::::V:::::::::::::::::E::G:::SE::::

consensus       VTTGVGAATALQDMAEADIQLLV
#oth            ..1.....1.2.2.211.1..11
HVO_1367        ::::::::::::H::D::V::MI
hla0860         ::::::::S:F:::VD:::::::
NP0976A         ::::::::S:F:E:Q::::::::
rrnB0284        ::V:::::::::H:::S::::::
Hbo3420         ::::::::::I::::D::V::MI
VNG5059         :::::::::::::::::::::::
VNG5238         :::::::::::::::::::::::
VNG6057         :::::::::::::::::::::::
VNG6469         :::::::::::::::::::::::
Hmu3300         :::::::::::::::D:::::::