[H] (CobF) COG2243 Precorrin-2 methylase 8 genomes BUD0993 8 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG1551 rrnAC3000 HVO_B0061 Hbo1626 Hmu1992 - hla2065 NP1122A HQ1833A

Pairwise sequence scores
Consensus score	1772	NP1122A	rrnAC3000	HQ1833A	HVO_B0061	Hbo1626	VNG1551	Hmu1992	hla2065
1346	NP1122A	1736	1279	1149	1194	1173	1154	1300	1261
1469	rrnAC3000	1279	1990	1188	1342	1312	1359	1333	1423
1330	HQ1833A	1149	1188	1749	1357	1398	1214	1179	1221
1535	HVO_B0061	1194	1342	1357	1758	1564	1372	1320	1358
1550	Hbo1626	1173	1312	1398	1564	1804	1362	1292	1368
1462	VNG1551	1154	1359	1214	1372	1362	1783	1316	1384
1464	Hmu1992	1300	1333	1179	1320	1292	1316	1908	1479
1530	hla2065	1261	1423	1221	1358	1368	1384	1479	2197

289 symbols
consensus       MTLYGVGLGPGDADLVTVRGKRVLESADVVYSPGRLSRTVATNHVPEERIGDLDFPMTRD
#oth            1.1..1.....312.2.11.224.12121..1......2..251.12111........1.
NP1122A         :::::::::::N:G:I::::RE:::::::::T::::::N:::EY:D:SQL::::::::::
rrnAC3000       :::::I:::::QP:::::::::A:::::::::::::::S:::K:::::::::::::::::
HQ1833A         ::V:::::::::PK::::K:RDI:D:VTT::::::::::::RQ:::SS::::::::::::
HVO_B0061       ::V::I:::::E::::::K:::L::::A:::::::::::::L::::::::::::::::::
Hbo1626         ::V:::::::::::::::K:::I:::V::::::::::::::L::::::::::::::::::
VNG1551         ::V::::::::EP::L:L::::T::A::::::::::::::::H:::DS::::::::::S:
Hmu1992         V:::::::::::::::::::RE:::T:::::T::::::S:::AY:D::::::::::::::
hla2065         ::::::::::::::::::::Q::::T::::::::::::::::E::::S::::::::::::

consensus       PDELRRAWKAAAAEVAPRARDGDVAFVTLGDPNVYSTFGHLRRTLDAFHPAVDLEVVPGV
#oth            211..1..12..311.23.51211..1.................12....3131111...
NP1122A         EEK:::::::::EA:::V:T::TA:::::::::::::::::::::::::::::V::::::
rrnAC3000       EEK::A:::E::::I::T:::::A:::::::::::::::::::::A::::E:::::::::
HQ1833A         ::K::::::D::NA::EK:MSD:::::::::::::::::::::::S:::::ISV::I:::
HVO_B0061       :::::::::E::::::A::DSE::::::::::::::::::::::::::::E:::::::::
Hbo1626         :::::::::E::::::E::ES:::::::::::::::::::::::::::::::E:::::::
VNG1551         :EK::A::RD::::::::::::::::A:::::::::::::::::::::::DI:VQT::::
Hmu1992         E:::::::::::::I:::::::TA::::::::::::::::::::::::::G:TV:T::::
hla2065         A:::::::::::S:I::::C::::::::::::::::::::::::F:::::E:::::::::

consensus       SAMTAFATALGVEIEAGAGLALREAARGAAPTGPDRMILFKVTDAPATHEGLVEAGYDVT
#oth            .111..1...11.131.22.2.1..13.21.1....11......112.1.2.22...2.4
NP1122A         :TV:::::::D:::T::SE::::::DG::::V::::LV::::::V:T:::K:R::::E::
rrnAC3000       :::S::::::::::T::SS::::::D:::S:::::::::::::::::::::::::::::V
HQ1833A         ::::::::::DI:::S:T::S:::::N:S::::::::::::::::VE:::K:TA:::N:Q
HVO_B0061       ::::::T::::::::S:T::::::::N::::::::::V::::::::::::K:T::::::R
Hbo1626         :::::::::::::::S:T::S:::::N:::::::::::::::::::::Y:::T::::::K
VNG1551         ::VS::T::::::VD:::::::::::Q::S:::::::::::::::::::::::D::::::
Hmu1992         ::VS::T::::::VA:::S:T:H::::::::::::::V::::::V:::::R::D:::E:V
hla2065         ::V:::T::::::VA:::S:::H:::::H:::::::::::::::V::::::::D::::::

consensus       YGRRLFMEQGETVVTDDPAEIAERDYYTLAYAEREGLEREPATAAF--------------
#oth            1....1.1211131.31.52231.....1....132446232.13.21212121111111
NP1122A         :::::::DGH:S:I:::::AL:::::::V:::::PEALE::V::::::::::::::::::
rrnAC3000       ::::::::::::::::::TD:D:::::::::::KPETRV:Q::D::LEAADES:::::::
HQ1833A         F:::::::::::MI:T::T:::::::::::::::::I:QTVP::::::::::::::::::
HVO_B0061       F:::::::::::::::::D:L:::::::::::::::V::DV:::E:::::::::::::::
Hbo1626         F:::::::::::L::SN:Q::::::::::::::::::::DV:::E:::::::::::::::
VNG1551         :::::Y::::D:T::R::::::D:::::::::::DT:QKDR:::-:::::::::::::::
Hmu1992         :::::Y::::::::::::E:LT:::::::::::KR:::A:::::T:::::::::::::::
hla2065         :::::Y::H::::::S::S:VVD::::::::::KR::DD:::::T:AETAGEDTERARGE

consensus       --------------DGVSDDGEA--------------------------
#oth            1111111111111135444544224433433222313322233322111
NP1122A         ::::::::::::::E:::::---::::::::::::::::::::::::::
rrnAC3000       ::::::::::::::GV:T:G::NGSGEVVRQERSAAALCGDEVQHD:::
HQ1833A         ::::::::::::::NTS:EESV-::::::::::::::::::::::::::
HVO_B0061       :::::::::::::::::ESG:S:::::::::::::::::::::::::::
Hbo1626         :::::::::::::::AE:A:TD:VEPEVSK:::::::::::::::::::
VNG1551         :::::::::::::::DTEVA:D:::::::::::::::::::::::::::
Hmu1992         ::::::::::::::ETADER:::GTAVEATDGDASADASAGGQR:::::
hla2065         PDSTGDDRPESRDGESSA:PA::GPSAAERTERAVAESCGDDPVEGSVE