[R] (ComEC) COG2333 Predicted hydrolase (metallo-beta-lactamase superfamily) 3 genomes BUD2596 3 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG6354 rrnAC2645 - - - - hla1378 - -

Pairwise sequence scores
Consensus score	3603	VNG6354	rrnAC2645	hla1378
2576	VNG6354	3594	1961	2006
2740	rrnAC2645	1961	3645	2221
2852	hla1378	2006	2221	3596

487 symbols
consensus       MIRSRRLEAVLAVVGLVVLAGCAGGAANGDPASAD-STAQATTTNAAPDIAAANGELEVH
#oth            12211112211111121.1...1.2221.2121111212221.12222221.11.2.1..
VNG6354         -MSL:::L::F::::M::I::::::ID::E::TSG:V:E:::::V:TTET::PT:::V::
rrnAC2645       :V::P:V:S-:::AA:L:::::G:FV:::VDS:::Q:::TE:::PD::SP:::::T::::
hla1378         ::H::K:SH::LL::V::::::::-:SL:::I::::-----A:P:SGS::T::::S::::

consensus       QINVGQSVSTLVVEPDGETMLIDTGDFTDDGEYVLAYLRRQGITRIDHLVSSHNDADHIG
#oth            21....111..112..1..1.1.1.121...11.12..211111....1.2..1......
VNG6354         :L::::GS:::::G:::::L::::::W:::::D:I:::ES::V:::::::T::P::::::
rrnAC2645       F:::::::A::L:S::N::::::S:::::::::::Q::D::::D::::F:V:::::::::
hla1378         Y:::::::::::I::::::::V:::HYN:::K:::E::::HD::::::::::::::::::

consensus       GNAAVIRHYETEADGVGAVYDPGIAASTATYEEYLDAVEAHNVTLYETREGDSIPFSGAT
#oth            .1..1.211..122.1.......1.1.12..11........1.1..1.11..11111121
VNG6354         :H::::E:F::NG::::::::::::S:S:::::::::::::::P::R:QA:::::M::::
rrnAC2645       ::::::::::::KS::::::::::::::Q:::R:::::::::::::::::::R:::::VE
hla1378         ::::I:DY:::::G:I:::::::L::::L::G:::::::::E:::::::::::VS:GKT:

consensus       ADVLGPPEPYLENEARNENSIVLRIQHGETSFLLPGDAEDDQEAYLVDTYGARLRSTVLK
#oth            221.1...1..1.11....1..12221.11..112..1.111.1.......11.21...1
VNG6354         :QI:A:::G::A::D:::::::VHV:F:AS:::::::G:TAS:E:::::::D::N::::V
rrnAC2645       TT:::::::::::A:::::N:::::E:::::::FT:::::::::::::::::A::A::::
hla1378         V::::::::::::::::::::::KLT::::::M:S:::::::::::::::::::Q:::::

consensus       AGHHGSASSTSGAFLDAVDPRVAVISSAYDSQYGHPHEEVLQRLTARSVPTYWTATHGDI
#oth            1.....21.1.111.1..2..11.1....1......1111.1.111..111.......11
VNG6354         V:::::R::::A:::E::S::::::::::E::::::::A::E::A:::I:::::::::T:
rrnAC2645       :::::::L::::PL:::::::TV:V:::::::::::NN:T::::::::::A::::::::T
hla1378         ::::::S::S::::::::G::::::::::::::::::::::::F:D:::S::::::::::

consensus       VFTSNGTAVTVATQRDAPTDPQSLRDGDPIEPGTGGDVVDR---ATAGSGGAPATDDDGD
#oth            111.1.1111.2..11...2121..2...11..1212112.11111211122121122.2
VNG6354         T:::::S:::::::Q::::TATE::S:::V::::::GL:::LVIP:::::TT:I::P::T
rrnAC2645       :L:::::::::S:::A:::::L:::T::::A::ATES:TP::::::YLPRSS:R::TP:P
hla1378         ::V:D::NIS:R:::::::E::::::::::::::P::::E:::::QI:::::V:VT:G::

consensus       TADDEA----TTATNTAGRLAIARIRADAAGDDRENLNDEYIVFENAGAEPLDLSGWTVA
#oth            .2212211111111212.2.212212.......111..1..111112.112.111...12
VNG6354         :EPA:-::::::S:S:::::DLVE:H:::::::A::::G:::TV:HT::SS:::::::L:
rrnAC2645       ::T:GG:::::P:E::S:D:I:D:V:::::::::D::::::V::R:::::::EMG::::S
hla1378         :T::S:GSDDE:::DSN:T::::T:N:::::::::T::::::::::E:T:T::::::::E

consensus       DAAGHSYTIPDGFTLAPDETLTLRTGSGTDTATELYWGSDSPIWNNGGDTVIVTDATGDT
#oth            .21.11.12.1.21.2.1111.12.......211....121.1...1...1211111121
VNG6354         ::::::::::E:TV:E:GDQ::IY::::::::::::::QS::V:::::::ISLR::::T:
rrnAC2645       :D::::::V::::::G::::V::H:::::::D:D:::::GR::::::::::T::::DNE:
hla1378         :EV:KR:AM:::V::::::::::::::::::ER:::::::::::::A:::::::NT:::R

consensus       VLEESY-
#oth            11111.1
VNG6354         :I::T::
rrnAC2645       I:KR:::
hla1378         ::::::E