[R] (-) COG2404 Predicted phosphohydrolase (DHH superfamily) 9 genomes BUD0629 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG2519 rrnAC2217 HVO_1824 Hbo1659 Hmu0429 Hut1659 hla1103 NP1428A HQ1067A

Pairwise sequence scores
Consensus score	2759	NP1428A	Hut1659	rrnAC2217	Hmu0429	VNG2519	hla1103	HQ1067A	HVO_1824	Hbo1659
2093	NP1428A	2793	1891	1913	1909	1772	1625	1658	1681	1688
2099	Hut1659	1891	2740	2085	2079	1687	1620	1593	1626	1702
2152	rrnAC2217	1913	2085	2836	2251	1749	1694	1595	1704	1753
2190	Hmu0429	1909	2079	2251	2776	1807	1678	1568	1654	1736
2090	VNG2519	1772	1687	1749	1807	2803	1753	1651	1794	1789
2044	hla1103	1625	1620	1694	1678	1753	3140	1885	1981	2111
1956	HQ1067A	1658	1593	1595	1568	1651	1885	3371	1952	2194
2046	HVO_1824	1681	1626	1704	1654	1794	1981	1952	3273	2317
2182	Hbo1659	1688	1702	1753	1736	1789	2111	2194	2317	3212

463 symbols
consensus       MDDWLIDDERLSLERKSILPGEGFFYPDSVDEERAEEEAAETLEDADVVVIADPDADGLA
#oth            11111.12341124.214...4...4.1242143515323253232332.11.3.....1
NP1428A         :::::::::TIP:H:R:::::::::V::::::TET:Q::R:::AG::R::V::::::::G
Hut1659         V:::::::D:::I::::::::::::H::T:E:IER:R:::D::A::GT::::::::::::
rrnAC2217       ::::::::D:::IG:::V:::::::I:::YE::Q::A::::::Q::G:I:::::::::::
Hmu0429         :::::::::::::::::::::::::L:::IE::EQ:R::::QM:STE:::::::::::::
VNG2519         :E::V::::D:::::::L:::R:::V::DIH:A:KDDAVR:RV:G:::I:V:::::::::
hla1103         :::E:::EADIPRS:YTR:::K:::::::L:D::::TR:K:VI:GSEAI::::G::::::
HQ1067A         :::E::NSAH:::S:::R:::A:::::::::DD--D:DTH:AVAN::::::::A:::::G
HVO_1824        :E:E:::SSQ:::P:::V:::A:::::E:F:::::::R:KAK::::S:A:VT:T:::::G
Hbo1659         :EEE:::SS::::S:::Q:::T:::::::L:::::::RVK:AV:::EA:::::T:::::G

consensus       CVALLREAY---------------------------------GDG---------------
#oth            .2.22.222112223221144234223221111111111111322442332323333331
NP1428A         ::::::V:F:::::::::::::::::::::::::::::::::D:A:::::::::::::::
Hut1659         ::::I:D:F::::::::::::::::::::::::::::::::::E::::::::::::::::
rrnAC2217       :T::I::::::::::::::::::::::::::::::::::::::E::::::::::::::::
Hmu0429         ::::V:::L::::::::::::::::::::::::::::::::::S::::::::::::::::
VNG2519         :A:I:::V::::::::::::::::::::::::::::::::::::A:::::::::::::::
hla1103         :A:MV::::DAALDAADFEAAITARL:::::::::::::::::::ESEADDGDSEDDPTE
HQ1067A         :::::::M:DATIAWDAFEPVVANRVTRWERGTDSTHTTDETT:ASTDDPSSELTKISQE
HVO_1824        :::::::::DAALDVADFEERIEEKLADDE::::::::::::::EDEDEDDEDESPLNEE
Hbo1659         ::::I::M:DATLDVAAFEDDVARRVERWE::::::::::::A::PIDDEDEDE::::::

consensus       ------------------------------ALIPAGPHELDDALERVAEYAEEDADVFVC
#oth            3331311111111111111111111241413.3411.1213331433331334143221.
NP1428A         ::::::::::::::::::::::::::::::R:L:::::::A:::AYID::G:PG::::I:
Hut1659         ::::::::::::::::::::::::::::::::LE:S::D:AR:F:W::::L:P:T:::::
rrnAC2217       ::::::::::::::::::::::::::::::::L:::::::TE:::WT::::DP::T::I:
Hmu0429         ::::::::::::::::::::::::::::::S:V::::::::E:::WA:::V:A::TLVI:
VNG2519         :::::::::::::::::::::::::::::::::::::::IE:G:R:AV::GN::CRL:::
hla1103         NAH::::::::::::::::::::::TQSSVG::A:::YSI:TS::::LA::DD:V:L:::
HQ1067A         TETEVKVENEHNNKDEDEDIVSTSSPESAV:::T:S:YSI::::ST::ME:PVGV::YI:
HVO_1824        AEEER::::::::::::::::::::PKSPV::MGSS:YS:E:D:Q:::D::P:GVE:Y::
Hbo1659         :DEEL::::::::::::::::::::PRSTV::VG:::YS::::::::::::P::I:AY::

consensus       DLCPDRFEDIE-ELAALAERAASVRWFDHHQWDDDLAAAVRDAGVDLVVGDSDEECTADV
#oth            .1...54422134.42332424524.1.....4422343.224112111.2.112.111.
NP1428A         :::::SPS::::R:QSV::D::A:::::::::::::TER::EHA-E:::::::TV::T::
Hut1659         :::::EAA:LA:G:DDIVA::G:::::::::::E:::GM:A::::T:T::E:::A:::::
rrnAC2217       ::::::ES::A:P:DS:VDT:ER:V:::::::P:::::D:DA:::ERT::::E:V:::::
Hmu0429         :::::SES::A:A:DD:TA:VDD:::Y:::::NE::G:::D:S:::RT::::::V:::::
VNG2519         :V::::::YV:T:::DAT:H:SEL::::::::TAET::::::::::::::::E:::::::
hla1103         :::::DYKW:AEP:E::::ST::I:::::::::EST::::::L:::::::E:::::::::
HQ1067A         :::::E:NW::T::T:V:D::ET:A:Y::::::SST:D::::C::E::I:A:::::ST::
HVO_1824        :::::K::YV:E:::::V:T:GEIH:Y:::::KPEV:E::::::::::::E:::::ST::
Hbo1659         :::::QY:WV:D:::::LD::D::S:Y:::::::ETMV:::::::E::::E:::::STG:

consensus       ALRSLDYDFDDRFAELAAVTRDHDLWIKEDERSDDLADYAYWAEPEEYVEVVGAYGADLP
#oth            113313211221241.13........131.4..1....111.54311.4331431.2.11
NP1428A         T:EAVA:::PEQY:::::::::::::LQ::P:::::::::H:V:::T:::T:IEH:P:::
Hut1659         ::AE::A::P:::VD:T::::::::::RD:P:::::::L:H:L:::::::IIR:H:::::
rrnAC2217       ::SE::::::EQW:D::::::::::::RD:P:::::::LS::S:::::I:A:RDH:P::S
Hmu0429         ::AQ:E:::::::::::::::::::::RD:::::::::LS::I:::::I:A:LEH:P::S
VNG2519         TV::::A:IPE::R:::E::::::::L:D:D::::::::S:::DTD::MDTIQE::::F:
hla1103         ::::::H:::::W::::V::::::::::::S::::::::S:::GS:::TTI:::::::::
HQ1067A         :::::P:E:ESQWS:::T::::::::::::A::::::::::::P::::AT:::T::::::
HVO_1824        T::E:::E::E::S::::::::::::LN:::::Q::::::::TSK::::A::::::::::
Hbo1659         T:::::::::::WT::::::::::::L:::::::::::::::VS:::::A::::::V:::

consensus       EEVEEFIEERRVEKEALIEAAVDRAELRDVGEWTVGVTYGRCSQNEVAEALREQGADAAV
#oth            3535322241.1..431.22.11..4443112...11...........121.12...12.
NP1428A         ::AV:LL::::::::::::K::E::TFET:::::::::::::::::::::M::A::::S:
Hut1659         TDA::LLA:::I:::::::K::E::Q::E::P::::::::::::::::::::::::::G:
rrnAC2217       P:FH::LD:K:::::::::K::::::::::::::::::::::::::::::::::::::::
Hmu0429         P:WH:::::K:::::::::K::E::Q::::::::::::::::::::::::::::::::::
VNG2519         DD:LAY::Q:::::HE:::R:::::SMKQID:::::::::::::::::::::::::::::
hla1103         :T:R::VAD:::::D:R:D::::::VTH:I:::::A:::::::::::::::::::::G::
HQ1067A         TLASRYL:L:::::N:::D::::::::TT::P::::I::::::::::::T::S:::::::
HVO_1824        PV:::Y:AH::::::N::Q::::::::KT::D::::::::::::::::D::::A::::::
Hbo1659         :I::Q:::L:::::QQ::D::L::::IKQ::P:::::::::::::::::G:::R::::::

consensus       IVKPAGSASIRGTETFERAHEVAGQVNGGGHPKAAGCKPDIYDDMLDYAHHWTTRGAVAK
#oth            1...1.......115.111....331......2.......1....1...2..113.332.
NP1428A         ::::::::::::::A:Q:C::::Q::::::::::::::::::::::::::::::::::T:
Hut1659         ::::::::::::::N::::::::A::::::::::::::::V:::::::::::::::::::
rrnAC2217       :::::::::::::DS::::::::Q:::::::::::::::::::::M::::::::Q:::::
Hmu0429         ::::::::::::::::::C::::A::::::::R:::::::V:::::::::::S:::::::
VNG2519         V:::S::::::::::::::::::::::::::::::::::::::::::::A:::SQ:TT::
hla1103         ::::::::::::S:D:QH::::::K:::::::Q::::::::::::::::Q::::E:QAC:
HQ1067A         V:::::::::::S:::::::::::RL::::::R:::::::::::::::::::::E:SP::
HVO_1824        V:::::::::::SDD:::C::::DL:::::::::::::::::::::::::::::Q::TT:
Hbo1659         V:::::::::::SDG:::::::::::::::::::::::::::::::::::::::N::A::

consensus       QVILDAFRRLAEEPA----------------EAD---------
#oth            22.13..241233322112221212212221432533211111
NP1428A         ::::::::S::D::::::::::::::::::::::A::::::::
Hut1659         :A:V::::::EV:E-::::::::::::::::---:::::::::
rrnAC2217       :A:V::::::P::EEE:::::::::::::::GV:TDR::::::
Hmu0429         :A:V:::K::P:::E::::::::::::::::A:E:::::::::
VNG2519         ::::::::A:PD:::::::::::::::::::D:E:::::::::
hla1103         R:::A::EAV:::V:A::::::::::ADESD:TETDE::::::
HQ1067A         HI::Q::EEV:ASL-:::::::::::::::::T:PNSS:::::
HVO_1824        R:::R::EQV:DAV:E::AEAEAAADAEADDD:EDDEGVETER
Hbo1659         R:::A::E:V::QV:EESEDEEGAETADADD:::KTES:::::