[K] (-) COG2524 Predicted transcriptional regulator, contains C-terminal CBS domains 9 genomes BUD0734 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG0890 rrnAC0451 HVO_1577 Hbo3471 Hmu1125 Hut0427 hla2393 NP3506A HQ2649A

Pairwise sequence scores
Consensus score	1324	VNG0890	HQ2649A	hla2393	HVO_1577	Hbo3471	NP3506A	Hut0427	rrnAC0451	Hmu1125
1011	VNG0890	1319	970	991	924	951	887	899	911	853
1120	HQ2649A	970	1327	1093	1132	1092	972	959	985	930
1139	hla2393	991	1093	1331	1116	1123	936	951	970	900
1172	HVO_1577	924	1132	1116	1334	1205	970	969	1005	924
1173	Hbo3471	951	1092	1123	1205	1328	969	952	1010	927
1057	NP3506A	887	972	936	970	969	1332	1047	1108	1001
1084	Hut0427	899	959	951	969	952	1047	1321	1124	1035
1138	rrnAC0451	911	985	970	1005	1010	1108	1124	1328	1147
1063	Hmu1125	853	930	900	924	927	1001	1035	1147	1232

179 symbols
consensus       MSSIELTSSQKTILQALINLYRESESAVKGEDIAEEVDRNPGTIRNQMQSLKALQLVEGV
#oth            1111111311132.21.1111323.3.....3..22.1......................
VNG0890         :::::::A::::V:R::VDR:TQQ:T:::::A::D:::::::::::::::::::::::::
HQ2649A         :::::::::::S::T:::::H::D:E:::::T::D:::::::::::::::::::::::::
hla2393         :::::::::::S::T::::::G:Q:D:::::A::::::::::::::::::::::::::::
HVO_1577        ::::::::::::::T:::::::D::D::::::::A::N::::::::::::::::::::::
Hbo3471         ::::::::::::::T:::::::QT:D:::::::::::N::::::::::::::::::::::
NP3506A         :::::::P:::::::E:::::::::::::::::::K::::::::::::::::::::::::
Hut0427         :::::::P:::N:::E:V::::D::::::::E:::R:N::::::::::::::::::::::
rrnAC0451       :::::::P:::N:::E:V:::::::::::::::::K::::::::::::::::::::::::
Hmu1125         -------------::E:V:::K:::::::::::::K::::::::::::::::::::::::

consensus       PGPKGGYKPTANAYEALDIQDMDEAAEVPLFHNGEEVEGANVDEIDLSSVHHPELCRAEI
#oth            ..........22..1..32241141.4..33.12142242..4211.2......3....2
VNG0890         ::::::::::VD::::::::QL:S:::::VT:E::DITDV::KKVN:T:::::::::::V
HQ2649A         :::::::::::::::::ELDQ:EDP:F:::::EN::INN:::E:::::::::::::::::
hla2393         ::::::::::S:::::::::R:::P:D::I::E::::T:V:::G::::::::::::::::
HVO_1577        ::::::::::::::::::VDK:::P:F::::::D:::::V::::::::::::::::::::
Hbo3471         ::::::::::::::::::VEQ:::P:S::::::::P:::V::::V:::::::::::::::
NP3506A         :::::::::::T::D::K::E:EQ::D::FN:E:DL::E:::Q::::T::::::::::::
Hut0427         :::::::::::T::D::Q:::::H:::::::::::QI:E:::A::N:A::::::N::::V
rrnAC0451       ::::::::::::::D::Q:::::Q::::::R::::L::HS::E::::T::::::E:::::
Hmu1125         ::::::::::::::D::Q:::::D::R:::R::::LL:D:::E::::T::::::K::::L

consensus       HLQGSVRDFHEGDSVTVGPTPLSKLQIEGTLDGKDDTSNILILRIDDMRAPAGE--PEH
#oth            331.1321221..223.........214.222....13131..4.12.4..3331114.
VNG0890         :FR::I::I:D::::I::::::::::VS::V:::::AKGVV::K::A:E:::D::::A:
HQ2649A         :I::::::::::::M::::::::::V::::I::::::::::::Q::::Q:::S::::A:
hla2393         :V:::::::::::::::::::::::V:D::V::::::A:V:::::::::::DEP::A::
HVO_1577        :V:::::E:::::KIR:::::::::V:D::::::::::::::::::::Q::V:::::Q:
Hbo3471         :V:::::E:::::E:R:::::::::VV::IV::::::::::::::E:::::E:::::S:
NP3506A         K::::MA::E:::KIS:::::::::L:::E:E:::::N:S:::T::N:A::::DED:L:
Hut0427         T::::LA:YD:::::::::::::::::V:::::::::::K:::T::::V:::EA:::::
rrnAC0451       Q:::TMSE:::::::::::::::::::I:::E:::::N:K:::A:::::::::::::::
Hmu1125         Q::::IS::::::::::::::::::::I:::A:::::::K:::T:::::::::::::::