[H] (MoaA) COG2896 Molybdenum cofactor biosynthesis enzyme 9 genomes BUD0113 10 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG0085 rrnAC1314 HVO_2789 Hbo2522 Hmu1361 Hmu2316 Hut0857 hla1385 NP2822A HQ2948A

Pairwise sequence scores
Consensus score	2565	Hut0857	Hmu2316	VNG0085	rrnAC1314	Hmu1361	NP2822A	hla1385	HVO_2789	Hbo2522	HQ2948A
2030	Hut0857	2910	1758	1943	1925	1927	1901	1791	1704	1826	1783
2048	Hmu2316	1758	2599	1832	1851	1801	1819	1753	1729	1840	1872
2135	VNG0085	1943	1832	2871	2197	2102	1849	1786	1775	1854	1904
2212	rrnAC1314	1925	1851	2197	2794	2198	1917	1885	1821	1949	1893
2156	Hmu1361	1927	1801	2102	2198	2591	1868	1846	1725	1861	1871
2135	NP2822A	1901	1819	1849	1917	1868	2534	1888	1843	1957	1916
2115	hla1385	1791	1753	1786	1885	1846	1888	2582	2006	2067	2012
1989	HVO_2789	1704	1729	1775	1821	1725	1843	2006	2475	2080	1938
2159	Hbo2522	1826	1840	1854	1949	1861	1957	2067	2080	2481	2071
2139	HQ2948A	1783	1872	1904	1893	1871	1916	2012	1938	2071	2511

409 symbols
consensus       ----------MLEDDFGREVSGVRVSLTDRCNFDCVYCHNEGLGDTRGPMDPQDDEMSTD
#oth            1111111223314131112321211........................221312.111.
Hut0857         :::::::::::::::::::LT:L:::::::::::::::::::::::::::A:SEE:L:::
Hmu2316         ::::::::::--------------::::::::::::::::::::::::::::::E::TA:
VNG0085         MRPVPGTSET::::::::D::::::::::::::::::::::::::::::I::REN:L:::
rrnAC1314       ::::::::::::::::::::::::::::::::::::::::::::::::::EA::::LTA:
Hmu1361         ::::::::::::S:E::::::::::::::::::::::::::::::::::LAA::::L:::
NP2822A         ::::::::::::::G::::TT:::I:::::::::::::::::::::::::E:AE::::::
hla1385         :::::::MTGP:A:::::::T:::I:::::::::::::::::::::::::E:S::::TA:
HVO_2789        :::::::::MV:V:::::::T:::I::::::::::::::::::::::::::AS:E:::A:
Hbo2522         ::::::::::::V:::::::::::I:::::::::::::::::::::::::E:S:::::::
HQ2948A         ::::::::::::::E:::::::::::::::::::::::::::::::::::::::::::::

consensus       DVVRFLEVAAEFGVDSVKFTGGEPMLRQDLEEIVRRTPDSMEVSLTTNGTFLPGRAADLV
#oth            3112212.143311331.1.....1..5..42.11.1.33212.1.....1.11..52.3
Hut0857         E:::VI::::DH::EA:::::::::::T::G:::::::AGV:T:M::::::::D:::E:A
Hmu2316         E:I:L:D:VR::::ETA:::::::::::::V:::::A::G::::M::::::::D:::A:A
VNG0085         R:::::S::H:::::A::L::::::::S:::A:I:::::D:A::M:::::::::::::::
rrnAC1314       TI:A:::::::::::::::::::::::E::::::::A::E::::M:::::::::::P:::
Hmu1361         R::D::::::DL::::::::::::L::E::A:::E::::E:A::::::::Y:::::SE::
NP2822A         ::I:::::::::DIQ:A::::::::::E:::T::::::::I:T::::::::::D::TA::
hla1385         ::::::::VEGY::::::::::::::::::::::E:::::::::::::::::::::E::K
HVO_2789        ::::::::VE:Y::EK:::::::::::A:::::I::::::::T:::::::::GD::E:::
Hbo2522         ::::::::VE::::EK::::::::::::::A::I::::E:::S:::::::::::::E::K
HQ2948A         ::::::::VSQ:DIGK:::::::::::D::T::I::::S:::::M:::::::::::GA:R

consensus       DAGLERVNVSQDALDPEAFAELTKSGAYDRVLEGVEAALDAGLAPVKLNMVVFEHTAGYV
#oth            2...2...1....21322.122.2.1..15.32.13..11...3...1....113..11.
Hut0857         :::::::::::::::::D::T::Q:::::Q::S:::::::::::::::::::::::::::
Hmu2316         :::::::::::::V::D::::::R:::::K:I:::::::G::::::::::::M:P:::::
VNG0085         ::::::::I::::M:ND::::::Q:::::A::::::::::::::::::::::::P:::::
rrnAC1314       :::::::::::::::S:::::::Q:::::::::::::::::::E::::::::::P:::::
Hmu1361         ::::::::I::::::R:::::::Q::::::::::::::V::::::::I::::::P:::::
NP2822A         ::::::::::::::S:K::QTV:::S:::D:MA:ID::::::::::::::::::Q:::::
hla1385         A:::D:::::::::::DD:::V::::::E::::::K::V::::D:::::::::T::::::
HVO_2789        A:::D:::::::::::::::QI:::::::K:T:::K::V::::T:::::::::TK:::H:
Hbo2522         E:::S::::::::::::::::I:::::::N:::::Q:::::::D::::::::::::::::
HQ2948A         E:::::::::::::::DE:::I::::::::::::::::V::::::::::::::::::E::

consensus       PEMVDHVAENDGLQLQLIEYMPELAGHPEWAIDIDRVHDWLADRADRVERREMHDRRRYF
#oth            13..21.2223..1....1....11.2...11..2...2..324.12125.2..2.3..2
Hut0857         ::::E:::DG:::R::::::::::::R:::::::::::::::EQ:TE:TA::::::T::W
Hmu2316         :Q::::::A::::::::::::::I::::::::::::::::::::::::::::::G::::Y
VNG0085         ::::::::AR:::R:::::::::::::::::::::::::::::::::I:T:::::::::W
rrnAC1314       :K::::::::P::::::::::::::::::::::::::::::E::::K::H::::::K::W
Hmu1361         :::::::V::E::R:::::::::::::::::::::::::::SE::::I:H:Q::::::::
NP2822A         ::::::::D:E:::::::::::::::R::::V::E:::E::::Q::::D:::::G:N:::
hla1385         E:::E:::D:E:::::::Q:::::T:K:::NV::E:::::::EK::::::::::::K:::
HVO_2789        E:::EY::::P:::::::Q:::::T:K:::N:::E:::R::T:L::E::V:D::H::::Y
Hbo2522         E:::::::::P:::::::::::::T:R:::N:::Q::::::EGK:::::M::::H::::Y
HQ2948A         ED::N::S::A:::::::::::::T:::::N:::Q::::::::I:::::T::::::N:::

consensus       V-----------------GEDDGD---------GGMVEIVDPVENEDFCANCHRVRVTHD
#oth            2433322323231221212423344321111115.1..1....1.34..1..1...1..1
Hut0857         IDG:::::::::::::::TP:::::::::::::::L::V::::G:T:::E::::::::::
Hmu2316         :GEDADAETPTIAA:::::DP::PAAE::::::Y:::::::::::AE:::::::::::::
VNG0085         :SSRDAGSTADDAAQSV:TP:G:AHPD::::::Q:::::::::G:PQ:::::::::L:::
rrnAC1314       MHSGEAAVEGDSASTSLAAS:G:IRTEPVNNHNS:::::::::G::N:::::::::L:::
Hmu1361         ::::::::::::::::::AS::::R::::::::E:::::::::G::T:::::::::L:::
NP2822A         ::::::::::::::::::::::P:RP:::::::::::::::::G:A:::::::::::::E
hla1385         :::::::::::::::::::::SD:DT::::::::::::::::::::N:::::G::::::E
HVO_2789        ::::::::::::::::::::----:::::::::-:::::::::::PE::::::::::::E
Hbo2522         :::::::::::::::::::Q----:::::::::-:::::::::::::::::::::::::E
HQ2948A         :::::::::::::::::::D----:::::::::-:::::::::::PT::::::::::::E

consensus       GYLKGCLNRNDDLRSMGEMTREEIREAFRETVANRVPYYGEYLVEDEDGEWEINEEYIDA
#oth            .11......1..1142.32125412312121.23........12343122133124.425
Hut0857         :::::::::::::::L:DRS::A:EA:L:D:::E:::::::::I::DN:::VR:PA:EGS
Hmu2316         :QF::::::H::H:A::::S:::::T:::::::S:::::::::::-:::::VR:DR:V:Q
VNG0085         ::::::::::::::GI::-:TQSM:A::::::::::::::::MTRTD::G::::DD:L:V
rrnAC1314       ::::::::::::::DI:T-:K:SM:A::::::DT::::::::MI:T:::::::::::::T
Hmu1361         :::::::::::::::I::-:KSRM:D:::A:::S::::::::M::T:::-::RD:R:R:G
NP2822A         :::::::::::::K::::::KP::::::::::DE::::::::M:Q::N:::RF:::::S:
hla1385         :::::::::::::::::::::D::A:T:EAV::::::::::::I:ND:::Y:L::K:LGT
HVO_2789        ::::::::::::::P:::::::D:::T:EAV:E:::::::::::R:G:DG:T::::::G:
Hbo2522         ::::::::::::::P::Q:::G:::::Y::::::::::::::::Q:::D::V:::K::G:
HQ2948A         ::::::::::::::::::::::::::T::::::::::::::::IKEN:E-:VL:DK:L::

consensus       PGDRA--------------------------------------------
#oth            4434322314312221111111111111111111111111111111111
Hut0857         K::::PYEYENDAPGSERADDQPATEKGGEDASHAATDGGESTGSVPDN
Hmu2316         :IST:DDD:::::::::::::::::::::::::::::::::::::::::
VNG0085         E:::DPYEYAADDSA::::::::::::::::::::::::::::::::::
rrnAC1314       D::::PYEYSE::::::::::::::::::::::::::::::::::::::
Hmu1361         E::::PYAYTED:::::::::::::::::::::::::::::::::::::
NP2822A         -----::::::::::::::::::::::::::::::::::::::::::::
hla1385         :STAD::::::::::::::::::::::::::::::::::::::::::::
HVO_2789        -----::::::::::::::::::::::::::::::::::::::::::::
Hbo2522         -----::::::::::::::::::::::::::::::::::::::::::::
HQ2948A         :TTHS::::::::::::::::::::::::::::::::::::::::::::