[E] (HutU) COG2987 Urocanate hydratase 4 genomes BUD1915 4 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG1208 rrnAC1787 HVO_A0562 Hbo2709 - - - - -

Pairwise sequence scores
Consensus score	4524	HVO_A0562	VNG1208	rrnAC1787	Hbo2709
3909	HVO_A0562	4762	3427	3529	3614
3915	VNG1208	3427	4534	3544	3513
3948	rrnAC1787	3529	3544	4501	3670
3998	Hbo2709	3614	3513	3670	4542

630 symbols
consensus       M-DQDTPSARHRVGEPSDQWRAYQGAPTGTDIECEGWRQEAALRMLNNNLDPEVAERPED
#oth            123232223223212..21.12.1.1........1.....................2..2
HVO_A0562       :H::QSSAR:D:L:D:::E:::::::::::::::K:::::::::::::::::::::::::
VNG1208         -:-M:::::AAETS:::A::Q::R::::::::::::::::::::::::::::::::D::N
rrnAC1787       :AQ:SA:DTD:D::T::E:::E::::::::::::::::::::::::::::::::::K::E
Hbo2709         -:MDE:D:E::T::::::E::R:::S::::::::::::::::::::::::::::::::::

consensus       LVVYGGTGRAARSWDAYDAILDELRELDDDETLLVQSGKPVGRFETHERAPRVLIANSNL
#oth            ........1.........1.121..2.2.2............2.2...1..1........
HVO_A0562       :::::::::::::::::::::T:::D::::::::::::::::T:P:::::::::::::::
VNG1208         ::::::::Q::::::::::::::::T:A:A::::::::::::V::::::::S::::::::
rrnAC1787       ::::::::::::::::::T:V::::::G:T::::::::::::::::::N:::::::::::
Hbo2709         :::::::::::::::::::::GQ:::::::::::::::::::::T:::::::::::::::

consensus       VGKWDDWEHFHELEAEGKIMYGQMTAGSWAYIGTQGIIQGTYETLAELARRHYPDNDGLR
#oth            ..2.11.11......1.....................1...1....111.31111121..
HVO_A0562       ::R:::::::::::::::::::::::::::::::::::::::::::::::QR:--DAD::
VNG1208         ::N:A:::Q::::::::::::::::::::::::::::::::F::::::::D:::::::::
rrnAC1787       :::::T:::::::::K::::::::::::::::::::::::::::::A:::K:::::::::
Hbo2709         :::::::D:::::::::::::::::::::::::::::L:::::::::AG:::F::DE:::

consensus       GKIVVTGGLGGMGGAQPLAVTMNRGVCIAAEVDEARIDRRIETGYCMEKADDLAEAIERA
#oth            .11.1.1.....1..........1........113..1..1..1.11.21.1121.1.1.
HVO_A0562       ::L:::::::::S:::::::::::::::::::QAD::E::V::D:L::F::S:D::L:N:
VNG1208         ::::A:A::::::::::::::::H::::::::::::::::::::::::RT:::G::::::
rrnAC1787       :::::::::::::::::::::::H::::::::::E:::::::::::Q:::::::A:::::
Hbo2709         :R::::::::::::::::::::::::::::::::H::::::::::::::T:SV:::::::

consensus       NAAAEAGEPYSVGVHGNAADMLEEMLERDFVPDVVTDQTSAHDELEGYYPSGYTVAEADR
#oth            31.122.1.1111.11....1.111.21111..............1....1....11..1
HVO_A0562       :::ID:::::::::QM::::::::L:A::EI:::::::::::::::::::::::::::::
VNG1208         T::::::D::::::::::::V::G::D::::::::::::::::::A::::::::::D::E
rrnAC1787       QE::AN::::G::::M::::::A::::MG:::::::::::::::::::::A::::E::::
Hbo2709         E::::E:::L:IA:::::::V:::::::G::::::::::::::::::::::::::E:::E

consensus       LREEDPDAYVEASLDTMERHVAAILELQDAGAIAFEYGNNIRGQVEAHRG--------RD
#oth            ..12..13.121.2...2...311.21.21..1............232111111111132
HVO_A0562       :::D::EK::D::::::::::Q:::D:::::::::::::::::::QN:::::::::::MT
VNG1208         ::D::::::R:::M:::A:::::V:AM:::::V::::::::::::A::::DVTTTAGESH
rrnAC1787       :::R::ET::AE:::::K:::EG:::::ER::::::::::::::::DQ:D::::::::L:
Hbo2709         :::::::R:::E:I:::::::DG:::M:AR::V:::::::::::::EYK:::::::::::

consensus       DAFDFPGFVPAYIRPLFCRGKGPFRWAALSGDPADIHRTDDAVRELFPEKDDLHRWIDLA
#oth            12.............1..1.1.....1....1.1......2.13.....212.2...1..
HVO_A0562       T::::::::::::::M::::R:::::::::::::::::::E:I::::::HES:M::::::
VNG1208         :P::::::::::::::::::::::::V::::N::::::::R::T::::::::::::::::
rrnAC1787       T:::::::::::::::::E::::::::::::::::::::::::K::::::::::::::::
Hbo2709         :V:::::::::::::::::::::::::::::::E:::::::::L:::::D:R:S:::E::

consensus       QEQVQFQGLPSRVCWLGYATDDDGLTERARFALRINELVANGEISAPVVVTRDHLDAGSV
#oth            1.1.11............212111....1.1.11..1.113..11..1............
HVO_A0562       ::::S:::::::::::::::::E::::::::::K::D:::S::V::::::::::::::::
VNG1208         ::H:::::::::::::::CAA::D::::::::V::::::D::::E::I::::::::::::
rrnAC1787       ::::S:::::::::::::::-E::::::T:L:::::::I:D:::::::::::::::::::
Hbo2709         R::::Y::::::::::::R::EE:::::::::::::::::E:::::::::::::::::::

consensus       ASPHRETEAMRDGTDAVADWPILNALLNCAAGADIVSVHDGGGVGIGNSLHTNNHVVLDG
#oth            ...2......1.................1..........1........1..1........
HVO_A0562       :::Y::::::::::::::::::::::::T::::::::::::::::::::::A::::::::
VNG1208         :::N::::::::::::::::::::::::T::::::::::N::::::::::::::::::::
rrnAC1787       ::::::::::K:::::::::::::::::::::::::::::::::::::::::::::::::
Hbo2709         ::::::::::::::::::::::::::::::::::::::::::::::::A:::::::::::

consensus       SDLAAEKARAVFTTDPGMGVIRHADAGYEDALDEADRSGVAVPMRDADRAQ---------
#oth            ..1..11..1..................12.121.2212131.11132232111111111
HVO_A0562       :::::K:::::::::::::::::::::::::::::T::N:RI::::H:A:ARTERSERSE
VNG1208         ::A:::T::R::::::::::::::::::A:::V:::A:::T::::::E:E::::::::::
rrnAC1787       :::::::::R:::::::::::::::::::I:QEM::END:::::::RN:N::::::::::
Hbo2709         :::::::::::::::::::::::::::::E:::::E:::AH::IDPE:TGP:::::::::

consensus       ------------------------AG----
#oth            111111111111111111111111112222
HVO_A0562       RSERADRADRTAEDGGHATETGES::RGDE
VNG1208         ::::::::::::::::::::::::--::::
rrnAC1787       ::::::::::::::::::::::::--::::
Hbo2709         ::::::::::::::::::::::::::AESK