[L] (-) COG3359 Predicted exonuclease 8 genomes BUD1049 8 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG1213 - HVO_1615 Hbo3232 Hmu2866 Hut2157 hla1453 NP5114A HQ2624A

Pairwise sequence scores
Consensus score	1954	VNG1213	NP5114A	HQ2624A	HVO_1615	Hbo3232	hla1453	Hmu2866	Hut2157
1262	VNG1213	2552	1010	1017	1078	1125	1117	980	1068
1373	NP5114A	1010	1877	1124	1161	1129	1301	1226	1148
1410	HQ2624A	1017	1124	2019	1162	1370	1292	1053	1060
1507	HVO_1615	1078	1161	1162	1943	1400	1401	1220	1173
1492	Hbo3232	1125	1129	1370	1400	1945	1462	1178	1153
1608	hla1453	1117	1301	1292	1401	1462	1952	1269	1208
1387	Hmu2866	980	1226	1053	1220	1178	1269	1982	1263
1394	Hut2157	1068	1148	1060	1173	1153	1208	1263	1960

343 symbols
consensus       ------------------------------------------------------------
#oth            111111111111111111111111111111111111111111111111111111111111
VNG1213         MSAAQQTYVHRSACRSGGRASDIGWPLPTATFDRLHCHATATRRPTSECAPDTERSAPRT
NP5114A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HQ2624A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HVO_1615        ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo3232         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
hla1453         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hmu2866         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hut2157         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       ----------------MRIENSFIPVRGVGERTERRLWRAGITHWDDFDPSL----VGPK
#oth            11111111222222221.2.1111215....31..51.341232.34.223511222.52
VNG1213         RPETALPMCQPPQAVD::V::::L:AA:::::::::::QH:V:::T:::GDG::PGI:DA
NP5114A         ::::::::::::::::::L::TY:A:D::::T:::E::AS:ART:SE:::::::::C::T
HQ2624A         ::::::::::::::::::::::::::S::::SR::S::E:D:IS:ER:::TD::AP::::
HVO_1615        :::::::::::::::::::::::::::::::::::N:::::A::::E::A::::::::A:
Hbo3232         ::::::::::::::::::::::::::H::::::::S::EE:VLT:EA::::V::AP::E:
hla1453         ::::::::::::::::::::::::::E::::T::::I::E:V:T:ES:::AVDVAG::ST
Hmu2866         :::::::MSDHTTYGSV:V:::::G::::::Q:::T::ES::::::::E::T::::::Q:
Hut2157         ::::::::::::::::V:V:Q::::::::::Q:::K:::Q::::::::Y:DA::::::ST

consensus       TADRIESFIADARERLDDGDSAYFDRQFPSGERWRLYENFRDETCFFDIETTGLDQHRDD
#oth            .132.11.2231352.1211341.3231.2213..1..2222322.........146425
VNG1213         ::EN:Y:::DA:ERA::A:NTSF:ADAL::::L::::::VA:DVA::::::::::::SSV
NP5114A         :::::::::EQ::P:::AD:::F::::L::S::::::::::::A::::::::::::M::T
HQ2624A         ::TA::::L:E:LP::::::TQ::NE:::DS:I::::::T:T::V::::::::::AGYN:
HVO_1615        :G::::T:::::AAH::::N:RF::DC::A::::::::::::::::::::::::SPE::S
Hbo3232         :GQ:::T:V:::L:::::::AR::GDA::::::::::::::ED::::::::::::SAQN:
hla1453         ::::::::::E:LTH:::::::::::T::::::::::::::E:::::::::::::E:::R
Hmu2866         :GE:::T::DEG:G::A:D:V::::E:::::::::V::T:AERA::::::::::::Q:NQ
Hut2157         ::E:::T::D::::::AH:::H::G:::::QAQ:::::S:Q:GAA:::::::::::RH:T

consensus       VTTVSFHQGGETTTLVRGDDLTAERLREQFADAPLLASFNGKRFDVPFLETAFDIS--ID
#oth            ..1..221211.2.1.214...2321223251141221...1...1...144..221111
VNG1213         :::::V:R::D:::::::S:::::::-QALL:::MV:::::::::A::::HH::L:::L:
NP5114A         ::C::I::::::E:::::::::QGN:-:ALL:G:::I::::A:::::::::::::D:::E
HQ2624A         ::::::::QD::::::::::::RN:V::::RT:::I::::::::::::::QC:::::::E
HVO_1615        ::::::Y:D:::::::S:E::::DA:::::V::K:I:T:::A:::::::::S::V:::::
Hbo3232         :::::::RD:::::::::H:::::A:::::T::A:V::::::::::::::DN::::::::
hla1453         :::::::RD:::::::A:E::::::::::::::S:::T:::A:::::::::::::E::::
Hmu2866         ::::::::::D:E:::A:::::::A:SATVG::D::VT::::::::::::AN::VD::L:
Hut2157         :::::VR:::::K:F::DR::::D::::V::::D::V::::::::::::QQS::LDGVL:

consensus       TPHLDLMYPCRRLDLTGGLKQIEKDVGIDRDR-PDLSGRDAVRLWREYER-GDDDALDTL
#oth            5..2..1.1.1222.1....41.422.12.1111.21.21.....43221212331.11.
VNG1213         S::::::::::::::::::::V:R:L:V::AEVD:VD::E::::::R:AEDN:EA:::R:
NP5114A         A:::::::::K:VG::::::A::PE::VE:::::::::K:::::::DH::::V:G::E::
HQ2624A         ::::::::::::VN::::::S::NEI:::::::::::::::::::SQ:K:SN:T:::E::
HVO_1615        V::V:::::::T::::::::E::::::::::::::I:::::::::::::::::QS:::::
Hbo3232         :::I::::::::::::::::S:::A::::::::::::::::::::HQ:::D::E::::::
hla1453         ::::::::::K:IG:S::::P:::EI::E:::::::::::::::::::::::::::::::
Hmu2866         L:::::L:T:KQ:G:S:::::::Q:I::E::::::I::Q::::::K:H::::E:GS:E::
Hut2157         R::::::::::QI:::::::::::::::Q:::::::::K::::::Y:A::::::A::E::

consensus       ISYNREDTVNLRTLADRVAERLHEDVF---------IDDPLE-
#oth            11..12.241.4322141232.134442111111214346651
VNG1213         VT::QY::Q::QAIL:A::::::R::::::::::::--E:HV:
NP5114A         :::::::::::K:V::SAV:::DRKLLP::::::::------:
HQ2624A         :::::D::::::N:::V::RT:::QSLGAATGTPCG:A::R::
HVO_1615        V::::::A:::ER:MET:TG:::DRAC:::::::EGL:AD:A:
Hbo3232         V::::D::A::SN:M:V:V:S::A:S-::::::::::GPF:::
hla1453         V:::::::K:::::::T:T:T:::::::::::::::VGETV:R
Hmu2866         :::::::A::::::::::TT::D:R:::::::::::V:PASQ:
Hut2157         :::::::VDH:E:V:::::T::::STV:::::::::P::CTF: