[S] (-) COG3372 Uncharacterized conserved protein 4 genomes BUD2284 6 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG5133 VNG6129 - HVO_1737 HVO_A0440 - - - - NP3848A HQ2177A

Pairwise sequence scores
Consensus score	3460	VNG5133	VNG6129	NP3848A	HQ2177A	HVO_1737	HVO_A0440
3137	VNG5133	3448	3448	2690	2721	2484	2560
3137	VNG6129	3448	3448	2690	2721	2484	2560
2938	NP3848A	2690	2690	3450	3023	2413	2489
2954	HQ2177A	2721	2721	3023	3464	2412	2495
2741	HVO_1737	2484	2484	2413	2412	3459	2672
2782	HVO_A0440	2560	2560	2489	2495	2672	3452

455 symbols
consensus       MLTADLARSRTRDGTITPLFIDTDDQQYRETAAELIQLFEDHLGEPKGELEDTIDELTVA
#oth            1...1......313211..1..22121..1..21..21..1..1111...111..1..21
VNG5133         :::::::::::::::V::::::::EP:::::::::::::::::::S:::::E::::::I:
VNG6129         :::::::::::::::V::::::::EP:::::::::::::::::::S:::::E::::::I:
NP3848A         :::::::::::YED::::::::::::R::D::E:::HI::E:::G::::::::::Q::A:
HQ2177A         :::::::::::DENS::::L::::E::::::::::::I::E::::SR::::::::Q:::S
HVO_1737        V:::::::::::::AVR:::::IS:E:::::::T::A:::::::::::::D:A:::::::
HVO_A0440       V:::N::::::T:E::::::::PA:ER:::::R::::::::::D::::::::A:::::::

consensus       DTDYKIVQGLAKLLKDECEFETVAAVDPREIRQRLFEKANERYPIVRQPTLGEDTQKLDV
#oth            .....11.......1...1..21.211111..32..12..221...........122221
VNG5133         :::::LI::::::::::::::::::A:::::::Q:::::::S::::::::::::AHW:::
VNG6129         :::::LI::::::::::::::::::A:::::::Q:::::::S::::::::::::AHW:::
NP3848A         ::::::::::::::::::::::::P:A:QR::EE::AV::DN:::::::::::::KSIW:
HQ2177A         ::::::::::::::::::::::::P::S:::::E:::V::RNH:::::::::::::SVWI
HVO_1737        ::::::::::::::R::::::QQ:::::::::K::::R::D:::::::::::::::::E:
HVO_A0440       ::::::::::::::::::K::V::S:::::::R:::::::::::::::::::::::::E:

consensus       YSAVADRLGISLEECYRGMYADLEDNKRLVRFGDRVADDYERG-DVSTTTTRLTGDSEQS
#oth            .111.11...1..2.11.......1.11..11.2122131221414132..2...2.213
VNG5133         :T:::::::::::Q:HQ::::::::::Q::Q:::::::::D::::::VA::::::::::T
VNG6129         :T:::::::::::Q:HQ::::::::::Q::Q:::::::::D::::::VA::::::::::T
NP3848A         ::T::E::::T:::::::::::::E:QQ:::::H::S:E::-:VED:::::::::N::E:
HQ2177A         ::T:::::::::::::::::::::E::::::::H::S:K::-:A:E:S::::::::::E:
HVO_1737        ::::::E:::::::::::::::::::::::::::QSVR:DSD:QEST::::K:::N:K:A
HVO_A0440       :::I::E::::::D:::::::::::::::::I:T:T::R:::TG:A:PS::N:::S:AEE

consensus       YAEDTITVDWLLTRYNLALAQAVLYDATEMRIRVWDHFGTVFSYVKLFGLMHRIYPIDTD
#oth            .22213..1...1.........1....12.22...11.1.1...1.............4.
VNG5133         ::::::::E:::::::::::::::::::Q:::::::::::A:::::::::::::::::::
VNG6129         ::::::::E:::::::::::::::::::Q:::::::::::A:::::::::::::::::::
NP3848A         :::::V:::::::::::::::::::::::::V::::S:A:::::::::::::::::::R:
HQ2177A         ::::::::::::::::::::::E:::::::W:::::S:A:::::::::::::::::::S:
HVO_1737        :DQRDQ::::::A::::::::::::::SK:HF:::E::::::::M:::::::::::::E:
HVO_A0440       :EHTDL::::::::::::::::::::::::::::::::::::::::::::::::::::A:

consensus       GNRVSSTDVADGYEAVLDGPASLFSQSRKYGIRMANFLPALPLCDRWEMEAEILDDEDGQ
#oth            .1..21..2.2....2...11...11.1.....11..............3.1..212223
VNG5133         :::::T::A::::::::::::::::::::::::LS::::::::::::::H::::N:::S:
VNG6129         :::::T::A::::::::::::::::::::::::LS::::::::::::::H::::N:::S:
NP3848A         ::::P::::::::::::::AV::::K:::::::::::::::::::::::::D::::DS:P
HQ2177A         ::::P::::::::::I:::A:::::K:::::::::::::::::::::::::D:::::S:S
HVO_1737        ::::A:::::A::::E::::V:::R::Q:::::::::::::::::::::R:::::E--:S
HVO_A0440       :D::::::Q:T::::::::::::::K:Q:::::::::::::::::::::T::::V:--ET

consensus       AGETLSFELDHTEGLSSHYSAQSDFDSDVERTLAQKWERANTDWDLVREDDVLDLGAEVM
#oth            322.21.3..312..2...12132..........1..1.21.1.2.2.....1...1...
VNG5133         R::::::G:::::::::::T:::::::::::::::::N::::::::::::::::::::::
VNG6129         R::::::G:::::::::::T:::::::::::::::::N::::::::::::::::::::::
NP3848A         SSR:::::::::::::::::::::::::::::::::::::::::E:I:::::::::::::
HQ2177A         ::R:::::::SSS:::::::::GE:::::::::::::::M::::K:::::::::::::::
HVO_1737        ::D:KQ:T::Y:D::V::::TGQR::::::::::R::::ST:E:::Q:::::F:::S:::
HVO_A0440       TN::RQ:A::QS:::D::::DGKR::::::::::::::::::::E:::::::F:::::::

consensus       IPDFAIEHPDGRRAILEIVGFWTPEYLEKKLAKIRDADRDNLIVAVSERLDCSADDFEGA
#oth            1....2.......122...........22..1.1.111321121......1.121..122
VNG5133         :::::L:::::::::::::::::::::::::::L::::V:H:L:::::::::::::::::
VNG6129         :::::L:::::::::::::::::::::::::::L::::V:H:L:::::::::::::::::
NP3848A         L::::V:::::::VLF:::::::::::DE::::::::::::::::::::::::::::::M
HQ2177A         L::::::::::::VVF:::::::::::D:::::::::::::::::::::::::S:::::M
HVO_1737        :::::::::::::::M:::::::::::AS::::::QVETH:FVL:::::::::DE::GDV
HVO_A0440       ::::::::::::::::::::::::::::S::E:::QVEAE:FVL::::::E:ASE::GSV

consensus       ADRVLWFKSGIHVYDVVELAEEYAIRSMPQ-TDH-
#oth            2..1....1.1....1..2.121.33332443331
VNG5133         S::L::::::::::::::V::DH::::::::---:
VNG6129         S::L::::::::::::::V::DH::::::::---:
NP3848A         D:::::::::::::::::::::::V---ETTLE::
HQ2177A         D:::::::::::::::::::::::VDGRAPDHR::
HVO_1737        ::::::::T:M:::::::::::::S---:VE::PD
HVO_A0440       ::::::::T::::::M::M:DQ::TGHA:AN::Q: