[S] (-) COG4044 Uncharacterized protein conserved in archaea 9 genomes BUD0391 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG0758 rrnAC0862 HVO_1175 Hbo0384 Hmu1533 Hut0975 hla1560 NP4104A HQ2490A

Pairwise sequence scores
Consensus score	1706	HQ2490A	VNG0758	hla1560	rrnAC0862	HVO_1175	Hbo0384	NP4104A	Hmu1533	Hut0975
1211	HQ2490A	2318	1014	1121	1020	1130	1251	1009	1062	1069
1341	VNG0758	1014	1681	1138	1213	1212	1144	1113	1223	1235
1393	hla1560	1121	1138	1763	1102	1279	1288	1120	1197	1198
1287	rrnAC0862	1020	1213	1102	1706	1120	1107	1156	1284	1187
1420	HVO_1175	1130	1212	1279	1120	1707	1388	1126	1275	1242
1387	Hbo0384	1251	1144	1288	1107	1388	1729	1103	1235	1240
1299	NP4104A	1009	1113	1120	1156	1126	1103	1689	1194	1220
1418	Hmu1533	1062	1223	1197	1284	1275	1235	1194	1691	1305
1417	Hut0975	1069	1235	1198	1187	1242	1240	1220	1305	1755

317 symbols
consensus       ------------------------------------------------------------
#oth            111111111111111111111111111111111111111111111111111111111111
HQ2490A         MDNKIPISRDTIHQSESLFNHSVRANINSNSNSNSTDSSLDNPTENIQTAHQSNTKSHDS
VNG0758         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
hla1560         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
rrnAC0862       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HVO_1175        ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo0384         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP4104A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hmu1533         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hut0975         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       --------------------MVVLATKCYVDGDARDRALDSLRSLVGNDIGELDVEWDIG
#oth            111111111111111111111.1.1..2.14.2113.11.115.125.2123.2.43321
HQ2490A         PDTSTNTDTDTDTDTDTDRAN:I:G::::I::S::::::::ME::IE::::::T:S:G:D
VNG0758         :::::::::::::::::::::::::::V::S::::E::::G::::::::::S:A:TV:V:
hla1560         ::::::::::::::::::::::::::::::E:::::::::GMN:::A::::::::D:QV:
rrnAC0862       ::::::::::::::::::::::::G::V::A::::::T::G:::M:::EL:D:::AY:::
HVO_1175        :::::::::::::::::::::::::::::I:::::E::::::T:::A::::D:::TY:::
Hbo0384         ::::::::::::::::::::::::::::::E::::E::::::D::IR::::::::S::::
NP4104A         :::::::::::::::::::::::::::L::S:ESQR::M:::E:::S:VLDG::::FTL:
Hmu1533         :::::::::::::::::::::::::::L:::::::Q::::::T:::::ELAD::::Y:V:
Hut0975         ::::::::::::::::::::::::::::::G:::::::::::G::LD::L::::::F:L:

consensus       VRDDDFPSVTVTGPDATVARNLLREEWGEITPH---LEAGETYVGTLDSWDDDGFVLDAG
#oth            2.2.2.23.123.3.132.2.2.4122.12214221334113.1...22..11.32..1.
HQ2490A         I:::A:IH::L::A:::A:S:::A:T::::HASTE:RTD::I:I:::::::ES:WT::V:
VNG0758         ::H::::T::LE:::EVA:::A:V:S::::::E:::F:S::::::::A::::::I:::::
hla1560         ::::::VQ:D:S:E::E::::V:A:T::::VA:DDG:::::E:::::E::::::::::::
rrnAC0862       L::::::T::LD:::E:::K::::::F::LVAD:::H:D::::::::::::E::::::V:
HVO_1175        ::::G:I::::S:D:E:::::V:::::::V:::::::S:::::::::EH:::::::::::
Hbo0384         ::::::I::::S:D:::A:::::GD::::V:::::::TE:::::::::E::E:::I::V:
NP4104A         L::::::::::::E::P::::::E::::A:V:::::R:P:GV:::::E:::E::L:::::
Hmu1533         I:::::::::I::::E:I:::::G::F:::V:T:::::::::::::::::::::::::V:
Hut0975         L:N:::::::::::::E:::::::::Y::::::::::VPE:::::::E::::::::::::

consensus       E--DVRIPADELGLGRGSPEQIRDRFGLVQHLPLRFV-----GDEDPA--RLADAERDRL
#oth            6246.21.23.11..3.113.113...1...2113.122214333224222.21432.3.
HQ2490A         G:EY:M:::S:::::Q:::T:V:::::I:::T::::I:::::AG:T:-::::::ST::Q:
VNG0758         ::::::V::A::D::P:T:S:::E:::::::M:::::::::HD:DG::::A:::::::::
hla1560         V::::Q:::::I:::::::::VVE::::::::SV:::YGGDV::P:AEPS::S:::::::
rrnAC0862       FGQT:::::::::::Q:T:S:::K::::::::::::::::::-PG:::::S::EV:Q:::
HVO_1175        I::E::::TE::::::::AT:::::::::::M::T::Y:::G:::G:S::::::EQV:::
Hbo0384         FHNY:::::::I:::T:::T:::::::I:::T::S::Y::::-:::GS::::S:ET::K:
NP4104A         :::A::::G::::::Q:::D:::K:::::::M:::::::::E:GD:::::::::::::::
Hmu1533         HGDS:::::::I:::::::::V:T::::::::::E:::::::-ND::P::::S::AQ:E:
Hut0975         R::P:::::::I:::P:T:::::T:::::::::::::CLSDGDG:T:PTG::D:D:::::

consensus       YEWTR--GSGRVNVNSATRGEVRATVNRAGHAQDIVTVERLGLLEQSVVCREDTDPPGLL
#oth            .1.2.2215..2.1..2..212...1......4..1..1.2....1.11.423..1...2
HQ2490A         :::::ET:A::::::::::::::::I::::::D:::::D:::::::::I:T::::::::I
VNG0758         :::::::::::L::::::::::::::::::::R:::::::I:::::::I:KDS:::::::
hla1560         :D:Q::::D::L:::::::::::::::::::::::I::::::::::::::T:::::::::
rrnAC0862       :::S:G:NN::I:A::V::S:A::::::::::::::::::I::::::II:NP::::::::
HVO_1175        :D::::::::::::::::::::::::::::::K::::::::::::::I:::DE:::::::
Hbo0384         :D:::EE:::::::::::::::::::::::::K::::::::::::::I::P:G:::::::
NP4104A         :D::::::N::::A::T::AQL:::::::::::::::::::::::C:::::::::A::::
Hmu1533         ::::::::Q::::::::::A::::::::::::::::::::V::::::I:::DE::::::V
Hut0975         ::::::::T::L:::::::A::::::::::::E:::::::::::::::::::G:::::::

consensus       ASIGSYLPAELLCVVP-
#oth            121.31221.1211231
HQ2490A         ::::::IR:::K::LT:
VNG0758         :A::QH::S:::A::::
hla1560         ::::::::::MR:::-:
rrnAC0862       :D::Q:M:S:::AI:::
HVO_1175        :::::::::::K::IGQ
Hbo0384         :::::::::::K::LT:
NP4104A         :D::P::E::::A::::
Hmu1533         S:::Q:::S::::I:::
Hut0975         ::V:E:::::::A::::