The Halobacterium sp. NRC-1 Genome

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tfbA

Gene ID2184
Gene NametfbA
Annotationtranscription initiation factor IIB
Locationchromosome:1618510←1617650
Gene typeFunctional gene
GC content72.01
Hydropathicity-0.435888501742161
DNA (861 bp, Edit)>tfbA|2184|1618510|Rev|1617650
atgcagcatccacaccgctgccctgaatgcgacggcaccatccgcgaaaccgacaccgagcacgtctgtgccgactgcgg
gctcgtcgtcacggacgcgcccatcgaccacgggcccgagtggcggacgttctccgacgaccccgatcacgcacccgagc
gtaccggcgcgccgctcacccgctcccggcacgaccgcggcctctcgaccgagatcggctacagcgcacggctcacgggc
cgcaaacgccgcaagttcgcacggctccgccgtcaacacaagcgcgccacgatcccctcgaaagccgactacaaccggat
ctacgggttcacggagatccgccgcctcatcggcacgttcggcatcggcaccgggctccgcgaccaggcctgcacgctgt
tcgcgtccgcccaaacggcgggcctgctccacggccgcaccatcgaggggttcgcggccgccggcgtctacgccacctgt
cggaccaacggggtcacccgcaccctcgacgaaatcgccgccgccgcccgcgccacccgccccgagctcaccaccgccta
cgacgccatgaaccgtgatctcgggctgccgaccggccccatcgacccccgcgaatacctcccacgatacgccgacgccc
tctccctgccggcccgcatcgagcgccaggcccgcgaactcgtcgccgcactcgaaaccgacggcctggtcgccggccga
aaccccagcggcgtcgccgccggctgcctctacaccgccgcaaccgagaccgaccacgccgtcacgcagtcggccgccgc
ggccgtcgccgacgtcacgccggtgacgctgcgcgcgacctaccagaacctcactgacgcctaa
pI7.7
MW (k)31.11245
Translation (287 aa, Edit)>tfbA|2184|gene
MQHPHRCPECDGTIRETDTEHVCADCGLVVTDAPIDHGPEWRTFSDDPDHAPERTGAPLTRSRHDRGLSTEIGYSARLTG
RKRRKFARLRRQHKRATIPSKADYNRIYGFTEIRRLIGTFGIGTGLRDQACTLFASAQTAGLLHGRTIEGFAAAGVYATC
RTNGVTRTLDEIAAAARATRPELTTAYDAMNRDLGLPTGPIDPREYLPRYADALSLPARIERQARELVAALETDGLVAGR
NPSGVAAGCLYTAATETDHAVTQSAAAAVADVTPVTLRATYQNLTDA
TfbA coordinates the expression of over 10% of genes in the Halobacterium NRC-1 genome together with TbpD, consistent with the role of these two transcription factors in gene regulation. Some of the regulated genes code for heat shock proteins and their deletion leads to a temperature sensitive phenotype. See Coker and DasSarma [BMC Genetics 2007 Sep 24;8:61](https://www.ncbi.nlm.nih.gov/pubmed/17892563).